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Germans, F.H. (author), Koster, M.W. (author), Kwee, H.H. (author), Groep Motoriek Revalidatie, Medisch Fysisch Instituut TNO Instituut voor gezondheidstechniek TNO (author)
The merits of the 'vacuum form fixation' are discussed for the production of reliable body impressions of patients suffering from sitting problems. Impressions are taken with the patients seated in the desired posture. The first results are reported, obtained from 4 patients of different categories, fitted with individually moulded seats...
article 1974
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von Lossonczy, T.O. (author), Ruiter, A. (author), Bronsgeest-Schoute, H.C. (author), van Gent, C.M. (author), Hermus, R.J.J. (author)
A cross-over study was done with 19 male and 23 female volunteers living in a monastery and a convent, respectively. The effect of a fat fish (mackerel) diet on the blood serum lipid composition was studied. As the normal diet of these volunteers was of the lacto-ovo-vegetarian type, a control diet in which the fish was replaced by full-fat...
article 1978
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Kluft, C. (author), Michiels, J.J. (author), Wijngaards, G. (author), Gaubius instituut TNO (author)
3 patients with Behcet's disease were studied for their fibrinolytic status during exacerbation of the disease accompanied with thrombotic complications. All 3 patients exhibited low euglobulin fibrinolytic activity. This, however, could be attributed to an artificially increased coprecipitation of inhibitors, i.e., C1-inactivator in the...
article 1980
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Schreurs, W.H.P. (author), van Rijn, H.J.M. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A study has been made of the serum 25-hydroxycholecalciferol (25-HCC) levels in six groups of women. Significant differences were found between the one pregnant group and the two reference groups as well as between the one pregnant group and two of the three groups using oral contraceptives. No significant differences were found between the...
article 1981
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Nooijen, W.J. (author), Koppert, P.W. (author), Gaubius instituut TNO (author)
A specific glucagon antiserum was generated in rabbits using a derivatisation of the methionine residue in glucagon. A sensitive and specific assay for glucagon has been developed. Interference with the assay system by plasma factors was abolished by both extraction of plasma samples and the production of glucagon-free plasma for each individual...
article 1981
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Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)
Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...
article 1981
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Brommer, E.J.P. (author), Leuven, J.A.G. (author), Barrett-Bergshoeff, M.M. (author), Schouten, J.A. (author), Gaubius instituut TNO (author)
Impairment of fibrinolysis is supposed to contribute to CVD. In 38 hyperlipoproteinemic patients, known to be at risk for early CVD, fibrinolytic activity was measured before and after stimulation with DDAVP. A negative correlation was found between serum triglyceride levels and fibrinolytic activity, both before and after DDAVP. A subnormal...
article 1982
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van Hinsbergh, V.W.M. (author), Havekes, L. (author), Emeis, J.J. (author), van Corven, E. (author), Scheffer, M. (author), Gaubius Instituut TNO (author)
Binding and metabolism of low density lipoprotein (LDL) and acetylated LDL were examined in endothelial cells from human umbilical cord arteries and veins. Both high and low affinity LDL interactions were observed. High affinity LDL binding and catabolism were increased five- to sevenfold after preincubation for 18 hours in LPDS containing...
article 1983
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Instituut CIVO-Toxicologie en voeding TNO (author), van Dokkum, W. (author), de Boer, B.C.J. (author), van Faassen, A. (author), Pikaar, N.A. (author), Hermus, R.J.J. (author)
We suggest that a lower faecal pH may be correlated with a lower mortality of large-bowel cancer and that faecal pH should always be considered in epidemiological studies on the role of diet in colon carcinogenesis.
article 1983
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Gevers Leuven, J.A. (author), Havekes, L. (author), van der Kooij-Pontier, H.A. (author), Starmans, R.J.H. (author), Jansen, H. (author), Bouwhuis-Hoogerwerf, M.L. (author), de Pagter, H.A.T. (author), Hessel, L.W. (author), Gaubius Instituut TNO (author)
Changes in circulating lipoproteins, which may be related to the risk for atherosclerotic vascular disease, were studied in a control group and in two groups of 24 or 26 women using different preparations of low-dose oral contraceptives for 3 months. One preparation contained 150 μg levo-norgestrel and 30 μg ethinylestradiol (Stediril-d 150/30);...
article 1984
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Tans, J.T.J. (author), Poortvliet, D.C.J. (author), Instituut voor Gezondheidstechniek TNO Medisch Biologisch Laboratorium TNO (author)
article 1984
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Vaandrager, G.J. (author), Bruining, G.J. (author), Veenhof, F.J. (author), Drayer, N.M. (author), TNO Preventie en Gezondheid (author)
The incidence of childhood diabetes (0-19 years of age) in The Netherlands, where there is no nationalized health-care system, was investigated retrospectively in the years 1978 to 1980 inclusive. The method chosen was a questionnaire among all Dutch paediatricians and internal physicians acting as consultants. Ascertainment was by the same...
article 1984
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Instituut CIVO-Toxicologie en Voeding TNO (author), Schrijver, J. (author), van Rijn, H.J.M. (author), Schreurs, W.H.P. (author)
The reference values of the three main types of serum haptoglobin Hp 1-1, Hp 2-1, and Hp 2-2, as determined by radial immunodiffusion and with phenotype determination on polyacrylamide gel electrophoresis have been re-evaluated for both sexes. For that purpose about 500 serum samples were collected from normal, healthy Dutch volunteers. The...
article 1984
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D'Angelo, A. (author), Kluft, C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinolytic system. The shut-down...
article 1985
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Bos, K.D. (author), Slump, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: amino acid, 65072-01-7; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; glutamine, 56-85-9, 6899-04-3; Glutamates; Glutamic Acid, 56-86-0; Glutamine, 56-85-9
article 1985
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Instituut voor Zintuigfysiologie TNO (author), Godthelp, J. (author)
This paper presents two experiments in which steering a lane-change manoeuvre is analysed as a precognitive control task. The suggestion that the dependence on instantaneous visual feedback is low during such a task was tested by analysing steering performance under conditions both with and without visual occlusion. Steering force served as the...
article 1985
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van den Berg, H. (author), Louwerse, E.S. (author), Bruinse, H.W. (author), Thissen, J.T.N.M. (author), Schrijver, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The vitamin B6 status of women suffering from premenstrual symptoms (PMS, n = 19) and a group of matched controls (n = 19) has been investigated. The women volunteering in the study were selected on strictly defined criteria. Several biochemical parameters of the metabolism of vitamin B6 and tryptophan were studied in blood and urine samples...
article 1986
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Gaubius instituut TNO (author), Boks, A.L. (author), Brommer, E.J.P. (author), Schalm, S.W. (author), van Vliet, H.H.D.M. (author)
In a study of severe, decompensated liver failure, we tried to find a correlation between hemorrhage and parameters of hemostasis and fibrinolysis. Three groups of patients were studied: alcoholic cirrhosis; nonalcoholic cirrhosis, and acute liver failure without known prior liver disease. The two cirrhotic groups did not differ significantly...
article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), van Dokkum, W. (author), Wesstra, A. (author), Luyken, R. (author), Hermus, R.J.J. (author)
Twelve young men were given for periods of 20 d, each of three mixed diets, namely a low-protein (LP) diet (9% total energy as protein, 67% of animal origin), a high-animal-protein (HA) diet (16% total energy as protein, 67% of animal origin) and a high-vegetable-protein (HV) diet (16% total energy as protein, 67% of vegetable origin). Retention...
article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), Odink, J. (author), van der Beek, E.J. (author), van den Berg, H. (author), Bogaards, J.J.P. (author), Thissen, J.T.N.M. (author)
The effects of maximal performance capacity and different work load intensities on the response of free and sulfate-conjugated plasma catecholamines, prolactin (PRL), and cortisol were studied in six healthy male volunteers. In a first experiment, the volunteers had to perform a step-wise incremental bicycle ergometer test to determine the onset...
article 1986
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