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Kaduk, M. (author), Hoefsloot, H.C.J. (author), Vis, D.J. (author), Reijmers, T. (author), van der Greef, J. (author), Smilde, A.K. (author), Hendriks, M.M.W.B. (author)
Modern chromatography-based metabolomics measurements generate large amounts of data in the form of abundances of metabolites. An increasingly popular way of representing and analyzing such data is by means of association networks. Ideally, such a network can be interpreted in terms of the underlying biology. A property of chromatography-based...
article 2014
document
Ramautar, R. (author), Berger, R. (author), van der Greef, J. (author), Hankemeier, T. (author)
Metabolomics provides a direct functional read-out of the physiological status of an organism and is in principle ideally suited to describe someone's health status. Whereas only a limited number of small metabolites are used in the clinics, in inborn errors of metabolism an extensive repertoire of metabolites are used as biomarkers. We discuss...
article 2013
document
Hu, C. (author), van der Heijden, R. (author), Wang, M. (author), van der Greef, J. (author), Hankemeier, T. (author), Xu, G. (author), TNO Kwaliteit van Leven (author)
Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes...
article 2009
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Angelova, N. (author), Kong, H.-W. (author), van de Heijden, R. (author), Yang, S.-Y. (author), Choi, Y.H. (author), Kim, H.K. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author), Xu, G. (author), Verpoorte, R. (author), TNO Kwaliteit van Leven (author)
This review summarises the most recent developments in ginseng analysis, in particular the novel approaches in sample pre-treatment and the use of high-performance liquid-chromatography-mass spectrometry. The review also presents novel data on analysing ginseng extracts by nuclear magnetic resonance spectroscopy and high-resolution mass...
article 2008
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Orešič, M. (author), Clish, C.B. (author), Davidov, E.J. (author), Verheij, E. (author), Vogels, J. (author), Havekes, L.M. (author), Neumann, E. (author), Adourian, A. (author), Naylor, S. (author), van der Greef, J. (author), Plasterer, T. (author), TNO Preventie en Gezondheid (author)
Multifactorial diseases present a significant challenge for functional genomics. Owing to their multiple compartmental effects and complex biomolecular activities, such diseases cannot be adequately characterised by changes in single components, nor can pathophysiological changes be understood by observing gene transcripts alone. Instead, a...
article 2004
document
Verhoeckx, K.C.M. (author), Bijlsma, S. (author), Jespersen, S. (author), Ramaker, R. (author), Verheij, E.R. (author), Witkamp, R.F. (author), van der Greef, J. (author), Rodenburg, R.J.T. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The discovery of new anti-inflammatory drugs is often based on an interaction with a specific target, although other pathways often play a primary or secondary role. Anti-inflammatory drugs can be categorized into classes, based on their mechanism of action. In this article we investigate the possibility to characterize novel anti-inflammatory...
article 2004
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