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van Ginneken, V. (author), Verheij, E.R. (author), de Vries, E. (author), Schouten, F. (author), van der Greef, J. (author)
There are currently two main directions with regard to nutritional supplements with PUFAs. The first research school recommends enriching the diet with the essential fatty acid (EFA) obtained from vegetable sources, the C18 lipid omega-3 molecule α-linolenic acid and then via the elongase/desaturase activity naturally in omega-3 Eicosapentaenoic...
article 2020
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He, M. (author), Harms, A.C. (author), van Wijk, E. (author), Wang, M. (author), Berger, R. (author), Koval, S. (author), Hankemeier, T. (author), van der Greef, J. (author)
Background. Rheumatoid arthritis (RA) is a complex, chronic autoimmune disease characterized by various inflammatory symptoms, including joint swelling, joint pain, and both structural and functional joint damage. The most commonly used animal model for studying RA is mice with collagen‐induced arthritis (CIA); the wide use of this model is due...
article 2019
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Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)
Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...
article 2018
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Sun, M. (author), Chang, W.T. (author), van Wijk, E. (author), He, M. (author), Koval, S. (author), Lin, M.K. (author), Van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author)
Based on the traditional Chinese medicine theory, the Chinese pharmacopeia assigns a therapeutic description of “taste” to all herbs; thus, an herb's “taste” is valued in traditional Chinese medicine as a major ethnopharmacological category and reflects the herb's therapeutic properties. These properties guide the practitioner with respect to...
article 2017
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Sun, M. (author), van Wijk, E. (author), Koval, S. (author), van Wijk, R. (author), He, M. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author)
The global prevalence of type 2 diabetes is estimated to reach 4.4% by 2030, placing a significant burden on our healthcare system. Therefore, the ability to identify patients in early stages of the disease is essential for both prevention and effective management, and diagnostic methods based on traditional Chinese medicine (TCM) may be...
article 2017
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He, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), Wang, M. (author), Sun, M. (author), Koval, S. (author), van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author)
The increasing prevalence of rheumatoid arthritis has driven the development of new approaches and technologies for investigating the pathophysiology of this devastating, chronic disease. From the perspective of systems biology, combining comprehensive personal data such as metabolomics profiling with ultra-weak photon emission (UPE) data may...
article 2017
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van Wietmarschen, H. (author), Schroen, Y. (author), Kallen, V. (author), Steijaert, M. (author), de Graaf, A. (author), van Ommen, B. (author), van der Greef, J. (author)
Western science has been strong in measuring details of biological systems such as gene expression levels and metabolite concentrations, and has generally followed a bottom up approach with regard to explaining biological phenomena. Chinese medicine in contrast has evolved as a top down approach in which body and mind is seen as a whole, a...
article 2017
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Sun, M. (author), van Wijk, R. (author), van Wijk, E. (author), Wang, M. (author), van Wietmarschen, H. (author), Hankemeier, T. (author), van der Greef, J. (author)
In Chinese medicine, raw herbal materials are used in processed and unprocessed forms aiming to meet the different requirements of clinical practice. To assure the chemical quality and therapeutic properties of the herbs, fast and integrated systematic assays are required. So far, such assays have not been established. Delayed luminescence (DL)...
article 2016
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Burgos, R.C.R. (author), Cervinková, K. (author), van der Laan, T. (author), Ramautar, R. (author), van Wijk, E.P.A. (author), Cifra, M. (author), Koval, S. (author), Berger, R. (author), Hankemeier, T. (author), van der Greef, J. (author)
Ultra-weak photon emission (UPE) is light emitted spontaneously by biological systems without the use of specific luminescent complexes. UPE is emitted in the near-UV/UV–Vis/near-IR spectra during oxidative metabolic reactions; however, the specific pathways involved in UPE remain poorly understood. Here, we used HL-60 cells, a human...
article 2016
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Fu, J. (author), Cuppen, B.V.J. (author), Welsing, P.M. (author), van Wietmarschen, H. (author), Harms, A.C. (author), Berger, R. (author), Koval, S. (author), Fritsch-Stork, R.D. (author), Bijlsma, J.W. (author), Hankemeier, T. (author), van der Greef, J. (author), Lafeber, F.P. (author)
Objective As there are pharmacological differences between males and females, and glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in rheumatoid arthritis (RA) patients, it is important to study serum polar lipid profiles of male and female patients in response to GC therapy. Gender differences may require...
article 2016
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Cuppen, B.V.J. (author), Fu, J. (author), van Wietmarschen, H.A. (author), Harms, A.C. (author), Koval, S. (author), Marijnissen, A.C.A. (author), Peeters, J.J.W. (author), Bijlsma, J.W.J. (author), Tekstra, J. (author), van Laar, J.M. (author), Hankemeier, T. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)
In clinical practice, approximately one-Third of patients with rheumatoid arthritis(RA) respond insufficiently to TNF-α inhibitors (TNFis). The aim of the study was to explore the use of a metabolomics to identify predictors for the outcome of TNFi therapy, and study the metabolomic fingerprint in active RA irrespective of patients' response. In...
article 2016
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Wietmarschen, H.A. (author), Wortelboer, H.M. (author), van der Greef, J. (author)
article 2016
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Sun, M. (author), Li, L. (author), Wang, M. (author), Van Wijk, E. (author), He, M. (author), van Wijk, R. (author), Koval, S. (author), Hankemeier, T. (author), van der Greef, J. (author), Wei, S. (author)
To improve the quality control of herbal drugs, there has been a major shift from evaluating individual chemicals to evaluating multiple-constituent chemicals, given the multi-pharmacology nature of herbal drugs. Therefore, rapid, systematic assays are needed in order to assess the quality of medicinal herbs using a comprehensive, integrated...
article 2016
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Fu, J. (author), Schoeman, J.C. (author), Harms, A.C. (author), van Wietmarschen, H.A. (author), Vreeken, R.J. (author), Berger, R. (author), Cuppen, B.V.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author), Hankemeier, T. (author)
Oxidised lipids, covering enzymatic and auto-oxidation-synthesised mediators, are important signalling metabolites in inflammation while also providing a readout for oxidative stress, both of which are prominent physiological processes in a plethora of diseases. Excretion of these metabolites via urine is enhanced through the phase-II...
article 2016
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He, M. (author), Sun, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), van Wijk, R. (author), Wang, Z. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author)
To present the possibilities pertaining to linking ultra-weak photon emission (UPE) with Chinese medicine-based diagnostics principles, we conducted a review of Chinese literature regarding UPE with respect to a systems view of diagnostics. Data were summarized from human clinical studies and animal models published from 1979 through 1998. The...
article 2016
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van der Greef, J. (author), Wietmarschen, H. (author), Schroën, Y. (author), Babouraj, N. (author), Trousselard, M. (author)
Background: The current health care system faces increasing costs and demands while the presence of chronic conditions in the general populations is rising. A shift from disease fighting toward health promotion is needed to prevent these conditions and empower people to work on their own health. In the Military setting, health promotion is...
article 2015
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He, M. (author), van Wijk, E. (author), Berger, R. (author), Wang, M. (author), Strassburg, K. (author), Schoeman, J.C. (author), Vreeken, R.J. (author), van Wietmarschen, H. (author), Harms, A.C. (author), Kobayashi, M. (author), Hankemeier, T. (author), van der Greef, J. (author)
Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA). The purpose of this research was to study differences in oxylipin levels between a widely used collagen induced arthritis (CIA) mice model and healthy control (Ctrl) mice....
article 2015
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Liping, Qu (author), Wenjun, Zou (author), Zhenxiang, Zhou (author), Tingmo, Zhang (author), van der Greef, J. (author), Wang, M. (author)
article 2014
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Vis, D.J. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Roelfsema, F. (author), van der Greef, J. (author), Hendriks, M.M.W.B. (author), Smilde, A.K. (author)
Relations among hormone serum concentrations are complex and depend on various factors, including gender, age, body mass index, diurnal rhythms and secretion stochastics. Therefore, endocrine deviations from healthy homeostasis are not easily detected or understood. A generic method is presented for detecting regulatory relations between...
article 2014
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van Wijk, R. (author), van Wijk, E.P.A. (author), van Wietmarschen, H.A. (author), van der Greef, J. (author)
For decades, the relationship between ultra-weak photon emission (UPE) and the health state of the body is being studied. With the advent of systems biology, attention shifted from the association between UPE and reactive oxygen species towards UPE as a reflection of changed metabolic networks. Essential for this shift in thinking is the...
article 2014
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