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de Groot, I.B. (author), Otten, W. (author), Dijs-Elsinga, J. (author), Smeets, H.J. (author), Kievit, J. (author), Marang-Van De Mheen, P.J. (author)
Objective. Publicly available information on hospital performance is increasing, with the aim to support consumers when choosing a hospital. Besides general hospital information and information on outcomes of care, there is increasing availability of systematically collected information on experiences of other patients. The aim of this study was...
article 2012
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Jansen, N.W.D. (author), Roosendaal, G. (author), Bijlsma, J.W.J. (author), de Groot, J. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)
Objective. Joint bleeding, or hemarthrosis, leads in time to severe joint damage. This study was carried out to test the in vitro thresholds of exposure time and concentration that lead to irreversible joint damage, to add to the discussion on the usefulness of aspiration of the joint after a hemorrhage. Methods. Explants of healthy human...
article 2007
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Scholten, N.P.M. (author), de Groot, E.H. (author), Zonneveldt, L. (author), TNO Bouw en Ondergrond (author)
article 2008
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de Bruin-Hordijk, T. (author), de Groot, E. (author)
article 2007
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Lamers, R.-J.A.N. (author), de Groot, J. (author), Spies-Faber, E.J. (author), Jellema, R.H. (author), Kraus, V.B. (author), Verzijl, N. (author), te Koppele, J.M. (author), Spijksma, G.K. (author), Vogels, J.T.W.E. (author), van der Greef, J. (author), van Nesselrooij, J.H.J. (author)
Osteoarthritis (OA), one of the most common diseases among the elderly, is characterized by the progressive destruction of joint tissues. Its etiology is largely unclear and no effective disease-modifying treatment is currently available. Metabolic fingerprinting provides a novel tool for the identification of biomarkers. A metabolic fingerprint...
article 2003
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Böhm, F.J. (author), Hirasing, R.A. (author), Vaandrager, G.J. (author), Reeser, H.M. (author), Bijlsma, F. (author), de Groot, R.M. (author), TNO Preventie en Gezondheid (author)
Objective. To determine the mortality of insulin-dependent diabetes mellitus in the age group of 0-19 year over the period 1988-1990 and to compare these data with those of ten years ago. Design. Retrospective. Setting. The Netherlands. Method. The number of deaths was obtained by using the data of the death certificate registers of the Central...
article 1996
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Verzijl, N. (author), Bank, R.A. (author), TeKoppele, J.M. (author), de Groot, J. (author), TNO Preventie en Gezondheid Gaubius instituut TNO (author)
Purpose of review: Across the world, osteoarthritis is the most commonly occurring musculoskeletal disease of the elderly, affecting more than 25% of the population older than 60 years of age. By far the single greatest risk factor for the development of osteoarthritis is age, but a mechanism to explain this relation has not yet been identified....
article 2003
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Kamphorst, J.J. (author), Tjaden, U.R. (author), van der Heijden, R. (author), de Groot, J. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Considerable interest exists in endogenous peptides as potential biomarkers, since they act as signaling molecules and are formed by degradation of proteins. A crucial step in the profiling of these peptides is the sample preparation, which aims to enrich the low-abundant peptides, while removing interfering matrix compounds. In a feasibility...
article 2009
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Castro-Perez, J.M. (author), Kamphorst, J. (author), de Groot, J. (author), Lafeber, F. (author), Goshawk, J. (author), Yu, K. (author), Shockcor, J.P. (author), Vreeken, R.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
A fast and robust method for lipid profiling utilizing liquid chromatography coupled with mass spectrometry has been demonstrated and validated for the analysis of human plasma. This method allowed quantification and identification of lipids in human plasma using parallel alternating low energy and high energy collision spectral acquisition...
article 2010
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Penninks, A.H. (author), Waalkens - Berendsen, I.D.H. (author), Wolterbeek, A.P.M. (author), Slob, W. (author), Piersma, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
Current developmental and reproductive toxicity protocols include only a limited set of parameters for effects on the developing immune system. In this study, a wide range of immunological parameters were included in a pre- and postnatal developmental toxicity study. Dose-response data were compared to determine the relative sensitivity of...
article 2010
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Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), van der Linden, J.C. (author), Zuurmond, A.M. (author), Weinans, H. (author), Verhaar, J.A.N. (author), van Osch, G.J.V.M. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)
Background: Damage to articular cartilage is one of the features of osteoarthritis (OA). Cartilage damage is characterised by a net loss of collagen and proteoglycans. The collagen network is considered highly important for cartilage function but little is known about processes that control composition and function of the cartilage collagen...
article 2008
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Coulier, L. (author), van Kampen, J.J.A. (author), de Groot, R. (author), Gerritsen, H.W. (author), Bas, R.C. (author), van Dongen, W.D. (author), Brüll, L.P. (author), Luider, T.M. (author), TNO Kwaliteit van Leven (author), KvL (author)
Nucleoside reverse transcriptase inhibitors (NRTIs) are activated intracellularly to their triphosphate (TP) form, which compete with endogenous deoxynucleotide-triphosphates (dNTP) as substrate for HIV reverse transcriptase. The activity of NRTIs is thus described by the NRTI-TP to-dNTP ratio in relevant cell types. Therefore, we developed an...
article 2008
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Beker van Woudenberg, A. (author), Wolterbeek, A. (author), te Brake, L. (author), Snel, C. (author), Menke, A. (author), Rubingh, C. (author), de Groot, D. (author), Kroese, D. (author)
Zebrafish embryos were exposed to different organotin compounds during very early development (<100. h post fertilization). Morphology, histopathology and swimming activity (in a motor activity test) were the endpoints analyzed. DBTC was, by far, the most embryotoxic compound at all time points and endpoints studied. In fact, we observed a clear...
article 2013
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Kosters, H.A. (author), Broersen, K. (author), de Groot, J. (author), Simons, J.W.F.A. (author), Wierenga, P. (author), de Jongh, H.H.J. (author), TNO Voeding (author)
Processing of ovalbumin may result in proteins that differ more than 23°C in denaturation temperature while the structural fold is not significantly affected. This is achieved by 1) conversion of positive residues into negative ones (succinylation); 2) elimination of negative charges (methylation); 3) reducing the proteins hydrophobic exposure ...
article 2003
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Santoro, A. (author), Pini, E. (author), Scurti, M. (author), Palmas, G. (author), Berendsen, A. (author), Brzozowska, A. (author), Pietruszka, B. (author), Szczecinska, A. (author), Cano, N. (author), Meunier, N. (author), de Groot, C.P.G.M. (author), Feskens, E. (author), Fairweather-Tait, S. (author), Salvioli, S. (author), Capri, M. (author), Brigidi, P. (author), Franceschi, C. (author), Fabbri, C. (author), Bertarelli, C. (author), Izzi, M. (author), Mazzocchi, M. (author), Chardigny, J.M. (author), Morio, B. (author), Rossi, D. (author), Notarfonso, M. (author), O'Toole, P.W. (author), Cashman, K. (author), Carding, S.R. (author), Nicoletti, C. (author), Jacobs, D. (author), Xipsiti, M. (author), Fernandez, L. (author), Wills, J. (author), Irz, X. (author), Kuosmanen, N. (author), Gonos, E.S. (author), Voutetakis, K. (author), Salmon, M. (author), Toussaint, O. (author), Traill, B.W. (author), Nocella, G. (author), Caracciolo, B. (author), Xu, W. (author), Ikonen, M. (author), Tuure, T. (author), Brummer, R. (author), Kadi, F. (author), Breton, S. (author), Triomphe, M. (author), Magario, G. (author), Villani, F. (author), Pancrazio, A. (author), Teufner, B. (author), Stocker, J. (author), Echevarría, F.J. (author), Iglesias, J.R. (author), Smrž, F. (author), Krejcirova, L. (author), Koytsomitropoulou, E. (author), Georgakidis, K. (author), Yornuk, R. (author), Ucar, C. (author), van Ommen, B. (author), Bouwman, J. (author), Collino, S. (author), Jankovics, C. (author), Losó, A. (author), de Vos, W. (author), Fuentes, S. (author), Commelin, E. (author)
The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale...
article 2014
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de Groot, E. (author), TNO Bouw en Ondergrond (author)
article 2006
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Verzijl, N. (author), de Groot, J. (author), Bank, R.A. (author), Bayliss, M.T. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), Maroudas, A. (author), TeKoppele, J.M. (author), Gaubius Instituut (author)
During aging, non-enzymatic glycation results in the formation and accumulation of the advanced glycation endproduct pentosidine in long-lived proteins, such as articular cartilage collagen. In the present study, we investigated whether pentosidine accumulation also occurs in cartilage aggrecan. Furthermore, pentosidine levels in aggrecan...
article 2001
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Claessens, M. (author), Contor, L. (author), Dhonukshe-Rutten, R. (author), de Groot, L.C.P.Q.M. (author), Fairweather-Tait, S.J. (author), Gurinovic, M. (author), Koletzko, B. (author), van Ommen, B. (author), Raats, M.M. (author), van 't Veer, P. (author)
The EURopean micronutrient RECommendations Aligned (EURRECA) Network of Excellence (NoE) explored an approach for settingmicronutrient recommendations, which would address the variation in recommendations across Europe. Therefore, a framework for deriving and using micronutrient Dietary Reference Values (DRVs) has been developed. This framework...
article 2013
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Hille, E.T.M. (author), Weisglas-Kuperus, N. (author), van Goudoever, J.B. (author), Jacobusse, G.W. (author), Ens-Dokkum, M.H. (author), de Groot, L. (author), Wit, J.M. (author), Geven, W.B. (author), Kok, J.H. (author), de Kleine, M.J.K. (author), Kollée, L.A.A. (author), Mulder, A.L.M. (author), van Straaten, H.L.M. (author), de Vries, L.S. (author), van Weissenbruch, M.M. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE. Young adults who were born very preterm or with a very low birth weight remain at risk for physical and neurodevelopmental problems and lower academic achievement scores. Data, however, are scarce, hospital based, mostly done in small populations, and need additional confirmation. METHODS. Infants who were born at <32 weeks of...
article 2007
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Henneman, S. (author), Bildt, M.M. (author), de Groot, J. (author), Kuijpers-Jagtman, A.M. (author), Von den Hoff, J.W. (author), TNO Kwaliteit van Leven (author)
article 2008
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