Searched for:
(1 - 20 of 48)

Pages

document
Jansen, N.W.D. (author), Roosendaal, G. (author), Bijlsma, J.W.J. (author), de Groot, J. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)
Objective. Joint bleeding, or hemarthrosis, leads in time to severe joint damage. This study was carried out to test the in vitro thresholds of exposure time and concentration that lead to irreversible joint damage, to add to the discussion on the usefulness of aspiration of the joint after a hemorrhage. Methods. Explants of healthy human...
article 2007
document
Verzijl, N. (author), Bank, R.A. (author), TeKoppele, J.M. (author), de Groot, J. (author), TNO Preventie en Gezondheid Gaubius instituut TNO (author)
Purpose of review: Across the world, osteoarthritis is the most commonly occurring musculoskeletal disease of the elderly, affecting more than 25% of the population older than 60 years of age. By far the single greatest risk factor for the development of osteoarthritis is age, but a mechanism to explain this relation has not yet been identified....
article 2003
document
Tonk, E.C.M. (author), de Groot, D.M.G. (author), Penninks, A.H. (author), Waalkens - Berendsen, I.D.H. (author), Wolterbeek, A.P.M. (author), Slob, W. (author), Piersma, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
Current developmental and reproductive toxicity protocols include only a limited set of parameters for effects on the developing immune system. In this study, a wide range of immunological parameters were included in a pre- and postnatal developmental toxicity study. Dose-response data were compared to determine the relative sensitivity of...
article 2010
document
Verzijl, N. (author), de Groot, J. (author), Bank, R.A. (author), Bayliss, M.T. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), Maroudas, A. (author), TeKoppele, J.M. (author), Gaubius Instituut (author)
During aging, non-enzymatic glycation results in the formation and accumulation of the advanced glycation endproduct pentosidine in long-lived proteins, such as articular cartilage collagen. In the present study, we investigated whether pentosidine accumulation also occurs in cartilage aggrecan. Furthermore, pentosidine levels in aggrecan...
article 2001
document
Henneman, S. (author), Bildt, M.M. (author), de Groot, J. (author), Kuijpers-Jagtman, A.M. (author), Von den Hoff, J.W. (author), TNO Kwaliteit van Leven (author)
article 2008
document
Blom, W.A.M. (author), Mars, M. (author), Hendriks, H.F.J. (author), de Groot, L.C.P.G.M. (author), Stafleu, A. (author), Kok, F.J. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author)
Objective: To study the role of ghrelin as a hunger signal during energy restriction and to test the hypothesis that changes in fasting leptin concentrations during energy restriction are associated with changes in fasting ghrelin concentrations. Research Methods and Procedures: Thirty-five healthy, lean men (23 ± 3 years of age; BMI: 22.3 ±1.6...
article 2006
document
Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), Weinans, H. (author), Jahr, H. (author), Verhaar, J.A.N. (author), de Groot, J. (author), van Osch, G.J.V.M. (author), TNO Kwaliteit van Leven (author)
Objective: Examine effects of insulin-like growth factor 1 (IGF1), transforming growth factor β2 (TGFβ2) and fibroblast growth factor 2 (FGF2) on proteoglycan and collagen network and biomechanical properties of the newly formed cartilage matrix. Methods: Bovine articular chondrocytes were cultured in alginate beads for 3 weeks with or without...
article 2006
document
Meulenbelt, I. (author), Kloppenburg, M. (author), Kroon, H.M. (author), Houwing-Duistermaat, J.J. (author), Garnero, P. (author), Hellio-Le Graverand, M.-P. (author), de Groot, J. (author), Slagboom, P.E. (author), TNO Kwaliteit van Leven (author)
Objective: To assess the relationship of biochemical markers and radiographic signs of osteoarthritis (ROA) in the subjects with symptomatic osteoarthritis (OA) at multiple sites of the Genetics osteoARthritis and Progression (GARP) study. Methods: We have measured eight biochemical markers, representing tissue turnover of cartilage, bone,...
article 2007
document
Yusuf, E. (author), Nelissen, R.G. (author), Ioan-Facsinay, A. (author), Stojanovic-Susulic, V. (author), de Groot, J. (author), van Osch, G. (author), Middeldorp, S. (author), Huizinga, T.W.J. (author), Kloppenburg, M. (author), TNO Kwaliteit van Leven (author)
Objective: To investigate the association between weight or body mass index (BMI) and the development of hand osteoarthritis. Methods: Systematic review of observational studies. Medical databases were searched up to April 2008. Articles that presented data on the association between weight and hand osteoarthritis were selected. The qualities of...
article 2010
document
Hunter, D.J. (author), Li, J. (author), LaValley, M. (author), Bauer, D.C. (author), Nevitt, M. (author), de Groot, J. (author), Poole, R. (author), Eyre, D. (author), Guermazi, A. (author), Gale, D. (author), Felson, D.T. (author), TNO Kwaliteit van Leven (author)
We used data from a longitudinal observation study to determine whether markers of cartilage turnover could serve as predictors of cartilage loss on magnetic resonance imaging (MRI). We conducted a study of data from the Boston Osteoarthritis of the Knee Study (BOKS), a completed natural history study of knee osteoarthritis (OA). All subjects in...
article 2007
document
de Groot, J. (author), Verzijl, N. (author), van Wenting-Wijk, M.J.G. (author), Jacobs, K.M.G. (author), van El, B. (author), van Roermund, P.M. (author), Bank, R.A. (author), Bijlsma, J.W.J. (author), TeKoppele, J.M. (author), Lafeber, F.P.J.G. (author), TNO Preventie en Gezondheid (author)
Objective. Osteoarthritis (OA) is one of the most prevalent and disabling chronic conditions affecting the elderly. Its etiology is largely unknown, but age is the most prominent risk factor. The current study was designed to test whether accumulation of advanced glycation end products (AGEs), which are known to adversely affect cartilage...
article 2004
document
de Groot, J. (author), Verzijl, N. (author), Jacobs, K.M.G. (author), Budde, M. (author), Bank, R.A. (author), Bijlsma, J.W.J. (author), TeKoppele, J.M. (author), Lafeber, F.P.J.G. (author), Gaubius Instituut (author)
article 2001
document
Intema, F. (author), Sniekers, Y.H. (author), Weinans, H. (author), Vianen, M.E. (author), Yocum, S.A. (author), Zuurmond, A.-M.M. (author), de Groot, J. (author), Lafeber, F.P. (author), Mastbergen, S.C. (author), TNO Kwaliteit van Leven (author)
In osteoarthritis (OA), cartilage degradation is accompanied by subchondral bone changes. The pathogenesis and physiology of bone changes in OA are still unclear. The changes in subchondral bone architecture and cartilage damage were compared in differently induced experimental models of OA. Experimental OA was induced bilaterally by anterior...
article 2010
document
de Groot, J. (author), Verzijl, N. (author), Wenting-Van Wijk, M.J.G. (author), Bank, R.A. (author), Lafeber, F.P.J.G. (author), Bijlsma, J.W.J. (author), Tekoppele, J.M. (author), Gaubius Instituut (author)
Objective. Progressive destruction of articular cartilage is a hallmark of osteoarthritis (OA) and rheumatoid arthritis (RA). Age-related changes in cartilage may influence tissue destruction and thus progression of the disease. Therefore, the effect of age-related accumulation of advanced glycation end products (AGEs) on cartilage...
article 2001
document
Lamers, R.J.A.N. (author), van Nesselrooij, J.H.J. (author), Kraus, V.B. (author), Jordan, J.M. (author), Renner, J.B. (author), Dragomir, A.D. (author), Luta, G. (author), van der Greef, J. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)
Objective: Osteoarthritis (OA) is one of the most common diseases among the elderly. The main characteristic is the progressive destruction of articular cartilage. We lack quantitative and sensitive biomarkers for OA to detect changes in the joints in an early stage of the disease. In this study, we investigated whether a urinary metabolite...
article 2005
document
Tchetverikov, I. (author), Kraan, M.C. (author), van El, B. (author), Hanemaaijer, R. (author), de Groot, J. (author), Huizinga, T.W.J. (author)
Objective: To analyse the effects of leflunomide and methotrexate treatment on matrix metalloproteinase (MMP) activity levels in a2 macroglobulin/MMP (α2M/MMP) complexes in the systemic circulation of rheumatoid arthritis (RA) patients. Methods: A total of 102 RA patients from a prospective, double-blind, randomised clinical trial comparing...
article 2008
document
Zuurmond, A.M. (author), Slot van der-Verhoeven, A.J. (author), van Dura, E.A. (author), de Groot, J. (author), Bank, R.A. (author), TNO Kwaliteit van Leven (author)
Collagen deposits in fibrotic lesions often display elevated levels of hydroxyallysine (pyridinoline) cross-links. The relation between the occurrence of pyridinoline cross-links and the irreversibility of fibrosis suggests that these cross-links contribute to the aberrant accumulation of collagen. Based on its inhibitory effect on lysyl...
article 2005
document
Tchetverikov, I. (author), Lohmander, L.S. (author), Verzijl, N. (author), Huizinga, T.W.J. (author), TeKoppele, J.M. (author), Hanemaaijer, R. (author), de Groot, J. (author), TNO Preventie en Gezondheid (author)
Objective: To determine protein and activity levels of matrix metalloproteinases 1 and 3 (MMP-1 and MMP-3) in synovial fluid of patients with knee joint injury, primary osteoarthritis, and acute pyrophosphate arthritis (pseudogout). Methods: Measurements were done on knee synovial fluid obtained in a cross sectional study of cases of injury (n...
article 2005
document
Sivan, S.S. (author), Tsitron, E. (author), Wachtel, E. (author), Roughley, P. (author), Sakkee, N. (author), van der Ham, F. (author), de Groot, J. (author), Maroudas, A. (author), TNO Kwaliteit van Leven (author)
During aging and degeneration, many changes occur in the structure and composition of human cartilaginous tissues, which include the accumulation of the AGE (advanced glycation end-product), pentosidine, in long-lived proteins. In the present study, we investigated the accumulation of pentosidine in constituents of the human IVD (intervertebral...
article 2006
document
Kamphorst, J.J. (author), van der Heijden, R. (author), de Groot, J. (author), Lafeber, F.P.J.G. (author), Reijmers, T.H. (author), van El, B. (author), Tjaden, U.R. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Synovial fluid potentially contains markers for early diagnosis and disease progression in degenerative joint diseases such as osteoarthritis. Here, a method is described for profiling endogenous peptides in human synovial fluid, using ultrafiltration, solid-phase extraction, nanoscale liquid chromatography, and high-resolution mass spectrometry...
article 2007
Searched for:
(1 - 20 of 48)

Pages