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van der Pal, S.M. (author), van der Meulen, S.A. (author), Welters, S.M. (author), Bakker, L.A. (author), de Groot, C.J.M. (author), van Kaam, A.H. (author), Verrips, G.H.W. (author)
Evidence suggests that increased survival over the last decades of very preterm (VPT; gestational age < 32 weeks)– and very low birth weight (VLBW; birth weight < 1500 g)–born infants is not matched by improved outcomes. The objective of our study was to evaluate the reproductive rate, fertility, and pregnancy complications in 35-year-old VPT...
article 2021
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Kolkman, D.G.E. (author), Martin, L. (author), Jans, S. (author), Wouters, M.G.A.J. (author), van Dommelen, P. (author), Fleuren, M.A.H. (author), de Groot, C.J.M. (author), Rijnders, M.E.B. (author)
Objective: Early onset group B streptococcal (EOGBS) disease is an important cause of neonatal morbidity and mortality. EOGBS preventive strategies aim to reduce the risk of neonatal complications. Two new strategies to prevent EOGBS were implemented in two regions in the Netherlands: a risk-based and a combination strategy and were compared to...
article 2020
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Kolkman, D.G.E. (author), Rijnders, M.E.B. (author), Wouters, M.G.A.J. (author), Dommelen, P.V. (author), de Groot, C.J.M. (author), Fleuren, M.A.H. (author)
Problem: Despite the introduction of preventive guidelines, no decrease in the incidence of early onset infection was observed. Background: Early onset group B streptococcal (EOGBS) infection is an important cause of neonatal morbidity and mortality. Aim: Our study was conducted to determine adherence to three guideline-based group B...
article 2020
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Groenenboom, A.E. (author), Parker, M.E. (author), de Vries, A. (author), de Groot, S. (author), Zobrist, S. (author), Mansen, K. (author), Milani, P. (author), Kort, R. (author), Smid, E.J. (author), Schoustra, S.E. (author)
Spontaneously fermented food products contain a complex, natural microbial community with potential probiotic activity. The addition of a health-promoting, probiotic bacterium to these products ensures the delivery of that probiotic activity to consumers. Here, we assess the microbial community of a traditional Senegalese milk product produced...
article 2019
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LaCroix, G. (author), Koch, W. (author), Ritter, D. (author), Gutleb, A.C. (author), Larsen, S.T. (author), Loret, T. (author), Zanetti, F. (author), Constant, S. (author), Chortarea, S. (author), Rothen-Rutishauser, B. (author), Hiemstra, P.S. (author), Frejafan, E. (author), Hubert, P. (author), Gribaldo, L. (author), Kearns, P. (author), Aublant, J.M. (author), Diabaté, S. (author), Weiss, C. (author), de Groot, A. (author), Kooter, I.M. (author)
In vitro air–liquid interface (ALI) cell culture models can potentially be used to assess inhalation toxicology endpoints and are usually considered, in terms of relevancy, between classic (i.e., submerged) in vitro models and animal-based models. In some situations that need to be clearly defined, ALI methods may represent a complement or an...
article 2018
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de Groot, J.F. (author), Damen, N. (author), de Loos, E. (author), Goorhuis, J. (author), Wagner, C. (author)
Background: Paediatric Early Warning Scores (PEWS) are increasingly being used for early identification and management of clinical deterioration in paediatric patients. A PEWS system includes scores, cut-off points and appropriate early intervention. In 2011, The Dutch Ministry of Health advised hospitals to implement a PEWS system in order to...
article 2018
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Husby, T. (author), de Groot, H.L.F. (author), Hofkes, M.W. (author), Filatova, T. (author)
article 2017
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Kolkman, D.G.E. (author), Fleuren, M.A.H. (author), Wouters, M.G.A.J. (author), de Groot, C.J.M. (author), Rijnders, M.E.B. (author)
Background. Actions to prevent early onset disease in neonates are based on different strategies including administering antibiotic prophylaxis during labour in case of 1) maternal GBS colonisation (screening strategy), 2) identified risk factors (risk-based strategy) or 3) a combination of these two conditions (maternal GBS colonisation and...
article 2017
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Bosch, A.A.T.M. (author), de Steenhuijsen Piters, W.A.A. (author), van Houten, M.A. (author), Chu, M.L.J.N. (author), Biesbroek, G. (author), Kool, J. (author), Pernet, P. (author), de Groot, P.C.M. (author), Eijkemans, M.J.C. (author), Keijser, B.J.F.5. (author), Sanders, E.A.M. (author), Bogaert, D. (author)
RATIONALE: Perinatal and postnatal influences are presumed important drivers of the early-life respiratory microbiota composition. We hypothesized that the respiratory microbiota composition and development in infancy is affecting microbiota stability and thereby resistance against respiratory tract infections (RTIs) over time. OBJECTIVES: To...
article 2017
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Jansen, M.J. (author), Slooff, L.H. (author), Bakker, J. (author), Carr, A.J. (author), Okel, L.A.G. (author), de Groot, K.M. (author), de Gier, B. (author), Harthoorn, A. (author), Jonkman, R. (author)
A full size TESSERA shade tolerant module has been made and was tested under various shadow conditions. The results show that the dedicated electrical interconnection of cells result in an almost linear response under shading. Furthermore, the voltage at maximum power point is almost independent of the shadow. This decreases the demand on the...
article 2017
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Energieonderzoek Centrum Nederland (author), Otjes, R.P. (author), de Groot, G.J. (author), Weijers, E.P. (author), van der Sterren, S. (author), Close, J.-P. (author), d. Groot, E. (author)
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article 2016
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Bosch, A.A. (author), Levin, E. (author), van Houten, M.A. (author), Hasrat, R. (author), Kalkman, G. (author), Biesbroek, G. (author), de Steenhuijsen Piters, W.A. (author), de Groot, P.K. (author), Pernet, P. (author), Keijser, B.J. (author), Sanders, E.A. (author), Bogaert, D. (author)
article 2016
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Matualatupauw, J.C. (author), Radonjic, M. (author), van de Rest, O. (author), de Groot, L.C.P.G.M. (author), Geleijnse, J.M. (author), Müller, M. (author), Afman, L.A. (author)
Scope: People who carry the apolipoprotein E4 (APOE4) single nucleotide polymorphism have an increased risk of cardiovascular disease (CVD). Fish-oil supplementation may help in the prevention of CVD, though interindividual differences in the response to n-3 PUFAs have been observed. We aimed to assess the impact of APOE genotype on peripheral...
article 2016
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Rottenkolber, M. (author), Voogd, E. (author), van Dijk, L. (author), Primatesta, P. (author), Becker, C. (author), de Groot, M.C.H. (author), Plana, E. (author), Alvarez, Y. (author), Durand, J. (author), Slattery, J. (author), Afonso, A. (author), Requena, G. (author), Huerta, C. (author), Alvarez, A. (author), de Abajo, F. (author), Tauscher, M. (author), Hasford, J. (author), Fischer, R. (author), Reynolds, R. (author), Schmiedl, S. (author)
Background: For patients with asthma, COPD, or asthma-COPD overlap syndrome (ACOS), inter-country comparisons of seasonal changes in drug prescriptions are scarce or missing. Hence, we aimed to compare seasonal changes in prescription rates of long-acting beta-2-agonist (LABA) in four European countries. Methods: A common study protocol was...
article 2015
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Rottenkolber, M. (author), Voogd, E. (author), van Dijk, L. (author), Primatesta, P. (author), Becker, C. (author), Schlienger, R. (author), de Groot, M.C.H. (author), Alvarez, Y. (author), Durand, J. (author), Slattery, J. (author), Afonso, A. (author), Requena, T. (author), Gil, M. (author), Alvarez, A. (author), Hesse, U. (author), Gerlach, R. (author), Hasford, J. (author), Fischer, R. (author), Klungel, O.H. (author), Schmiedl, S. (author)
Background: Inhaled, long-acting beta-2-adrenoceptor agonists (LABA) have well-established roles in asthma and/or COPD treatment. Drug utilisation patterns for LABA have been described, but few studies have directly compared LABA use in different countries. We aimed to compare the prevalence of LABA-containing prescriptions in five European...
article 2015
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van Gendt, A.W. (author), van der Pal, S.M. (author), Hermes, W. (author), Walther, F.J. (author), van der Pal-de Bruin, K.M. (author), de Groot, C.J.M. (author)
The aims of this study were to analyze reproductive outcomes of women and men born very preterm (gestational age <32 weeks) or with a very low birth weight (<1500 g) in 1983 in the Netherlands and to compare their reproductive outcomes with the total population at a similar age of 28 years. Young adults who were born after a pregnancy...
article 2015
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Wolterbeek, A. (author), Oosterwijk, T. (author), Schneider, S. (author), Landsiedel, R. (author), de Groot, D. (author), van Ee, R. (author), Wouters, M. (author), van de Sandt, H. (author)
Synthetic amorphous silica (SAS) like NM-200 is used in a wide variety of technological applications and consumer products. Although SAS has been widely investigated the available reproductive toxicity studies are old and do not cover all requirements of current OECD Guidelines. As part of a CEFIC-LRI project, NM- 200 was tested in a two...
article 2015
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Hollanders, J.J. (author), Israëls, J. (author), van der Pal, S.M. (author), Verkerk, P.H. (author), Rotteveel, J. (author), Finken, M.J.J. (author), Hille, E.T.M. (author), de Groot, C.H. (author), Kloosterboer-Boerrigter, H. (author), den Ouden, A.L. (author), Rijpstra, A. (author), Verloove-Vanhorick, S.P. (author), Vogelaar, J.A. (author), Kok, J.H. (author), Ilsen, A. (author), van der Lans, M. (author), Boelen-Van Der Loo, W.J.C. (author), Lundqvist, T. (author), Heymans, H.S.A. (author), Duiverman, E.J. (author), Geven, W.B. (author), Duiverman, M.L. (author), Geven, L.I. (author), Vrijlandt, E.J.L.E. (author), Mulder, A.L.M. (author), Gerver, A. (author), Kollée, L.A.A. (author), Reijmers, L. (author), Sonnemans, R. (author), Wit, J.M. (author), Dekker, F.W. (author), Weisglas-Kuperus, N. (author), van der Heijden, A.J. (author), van Goudoever, J.B. (author), van Weissenbruch, M.M. (author), Cranendonk, A. (author), Delemarre-Van De Waal, H.A. (author), de Groot, L. (author), Samsom, J.F. (author), de Vries, L.S. (author), Rademaker, K.J. (author), Moerman, E. (author), Voogsgeerd, M. (author), de Kleine, M.J.K. (author), Andriessen, P. (author), Dielissen-Van Helvoirt, C.C.M. (author), Mohamed, I. (author), van Straaten, H.L.M. (author), Baerts, W. (author), Veneklaas Slots-Kloosterboer, G.W. (author), Tuller-Pikkemaat, E.M.J. (author), Ens-Dokkum, M.H. (author), van Steenbrugge, G.J. (author)
Context: Transient hypothyroxinaemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective: To examine whether there is an effect of THoP on intelligence quotient (IQ) score and motor functioning at young adult age. Design:...
article 2015
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Vlaming, M.L.H. (author), Läppchen, T. (author), Jansen, H.T. (author), Kivits, S. (author), van Driel, A. (author), van der Steeg, E. (author), van der Hoorn, J.W. (author), Sio, C.F. (author), Steinbach, O.C. (author), de Groot, J. (author)
Introduction: The efflux transporters P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) are expressed at the blood-brain barrier (BBB), and can limit the access of a wide range of drugs to the brain. In this study we developed a PET-CT imaging method for non-invasive, quantitative analysis of the effect of ABCB1 and...
article 2015
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Santoro, A. (author), Pini, E. (author), Scurti, M. (author), Palmas, G. (author), Berendsen, A. (author), Brzozowska, A. (author), Pietruszka, B. (author), Szczecinska, A. (author), Cano, N. (author), Meunier, N. (author), de Groot, C.P.G.M. (author), Feskens, E. (author), Fairweather-Tait, S. (author), Salvioli, S. (author), Capri, M. (author), Brigidi, P. (author), Franceschi, C. (author), Fabbri, C. (author), Bertarelli, C. (author), Izzi, M. (author), Mazzocchi, M. (author), Chardigny, J.M. (author), Morio, B. (author), Rossi, D. (author), Notarfonso, M. (author), O'Toole, P.W. (author), Cashman, K. (author), Carding, S.R. (author), Nicoletti, C. (author), Jacobs, D. (author), Xipsiti, M. (author), Fernandez, L. (author), Wills, J. (author), Irz, X. (author), Kuosmanen, N. (author), Gonos, E.S. (author), Voutetakis, K. (author), Salmon, M. (author), Toussaint, O. (author), Traill, B.W. (author), Nocella, G. (author), Caracciolo, B. (author), Xu, W. (author), Ikonen, M. (author), Tuure, T. (author), Brummer, R. (author), Kadi, F. (author), Breton, S. (author), Triomphe, M. (author), Magario, G. (author), Villani, F. (author), Pancrazio, A. (author), Teufner, B. (author), Stocker, J. (author), Echevarría, F.J. (author), Iglesias, J.R. (author), Smrž, F. (author), Krejcirova, L. (author), Koytsomitropoulou, E. (author), Georgakidis, K. (author), Yornuk, R. (author), Ucar, C. (author), van Ommen, B. (author), Bouwman, J. (author), Collino, S. (author), Jankovics, C. (author), Losó, A. (author), de Vos, W. (author), Fuentes, S. (author), Commelin, E. (author)
The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale...
article 2014
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