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Schinkel, J. (author), Fransman, W. (author), Heussen, H. (author), Kromhout, H. (author), Marquart, H. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
Objectives: For regulatory risk assessment under REACH a tiered approach is proposed in which the first tier models should provide a conservative exposure estimate that can discriminate between scenarios which are of concern and those which are not. The Stoffenmanager is mentioned as a first tier approach in the REACH guidance. In an attempt to...
article 2010
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van de Ven, P. (author), Fransman, W. (author), Schinkel, J. (author), Rubingh, C. (author), Warren, N. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
The web-based tool "Stoffenmanager" was initially developed to assist small- and medium-sized enterprises in the Netherlands to make qualitative risk assessments and to provide advice on control at the workplace. The tool uses a mechanistic model to arrive at a "Stoffenmanager score" for exposure. In a recent study it was shown that variability...
article 2010
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Warren, N. (author), Meijster, T. (author), Heederik, D. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
Objectives: This paper presents a dynamic population-based model for the development of sensitisation and respiratory symptoms in bakery workers. The model simulates a population of individual workers longitudinally and tracks the development of work-related sensitisation and respiratory symptoms in each worker. Methods: The model has three...
article 2009
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Meijster, T. (author), Tielemans, E. (author), Schinkel, J. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Objectives: To effectively decrease occupational exposure to flour dust and related allergens, detailed information on exposure determinants and effectiveness of control measures is essential. In this paper, we use personal real-time exposure measurements to get more insight into the relationship between specific work characteristics, including...
article 2008
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Tielemans, E. (author), Noy, D. (author), Schinkel, J. (author), Heussen, H. (author), van der Schaaf, D. (author), West, J. (author), Fransman, W. (author), TNO Kwaliteit van Leven (author)
In The Netherlands, the web-based tool called 'Stoffenmanager' was initially developed to assist small- and medium-sized enterprises to prioritize and control risks of handling chemical products in their workplaces. The aim of the present study was to explore the accuracy of the Stoffenmanager exposure algorithm. This was done by comparing its...
article 2008
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Spaan, S. (author), Schinkel, J. (author), Wouters, I.M. (author), Preller, L. (author), Tielemans, E. (author), Nij, E.T. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Objectives: Workers in many industries are exposed to endotoxins, which may cause adverse health effects. In exposure assessment, information about exposure variability is essential. However, variability in exposure has rarely been investigated for biological agents and more specifically for endotoxin. Therefore, variance components and...
article 2008
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Tielemans, E. (author), Schneider, T. (author), Goede, H. (author), Tischer, M. (author), Warren, N. (author), Kromhout, H. (author), van Tongeren, M. (author), van Hemmen, J. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
The present paper proposes a source-receptor model to schematically describe inhalation exposure to help understand the complex processes leading to inhalation of hazardous substances. The model considers a stepwise transfer of a contaminant from the source to the receptor. The conceptual model is constructed using three components, i.e. (i) the...
article 2008
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Preller, L. (author), Balder, H.F. (author), Tielemans, E. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)
Objectives: To assess male lung cancer risks for industrial sectors in the Netherlands and to estimate the proportion of lung cancer attributed to working in specific industrial sectors. Methods: Associations were studied among men aged 55-69 years (n = 58 279) from the prospective Netherlands Cohort Study. 1920 incident lung cancer cases were...
article 2008
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TNO Kwaliteit van Leven (author), Marquart, H. (author), Heussen, H. (author), Le Feber, M. (author), Noy, D. (author), Tielemans, E. (author), Schinkel, J. (author), West, J. (author), van der Schaaf, D. (author)
In the scope of a Dutch programme to reinforce the working conditions policy on hazardous substances, an internet-based tool was developed to help small- and medium-sized companies to handle hazardous substances with more care. The heart of this tool, called the Stoffenmanager, is a risk banding scheme. It combines a hazard banding scheme...
article 2008
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Tielemans, E. (author), Bretveld, R. (author), Schinkel, J. (author), de Wendel van - Joode, B. (author), Kromhout, H. (author), Gerritsen-Ebben, R. (author), Roeleveld, N. (author), Preller, L. (author), TNO Kwaliteit van Leven (author)
The aim of this study was to assess exposure to pesticides for a longitudinal epidemiological study on adverse reproduction effects among greenhouse workers. Detailed information on pesticide use among greenhouse workers was obtained on a monthly basis through self-administered questionnaires and subsequent workplace surveys. Questionnaires were...
article 2007
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Links, I. (author), Jagt, K.E.V.D. (author), Christopher, Y. (author), Lurvink, M. (author), Schinkel, J. (author), Tielemans, E. (author), Hemmen, J.J.V. (author), TNO Kwaliteit van Leven (author)
Exposure data on biocides are relatively rare in published literature, especially for secondary exposure. This is also the case for antifouling exposure. Therefore, a field study was carried out measuring exposure to antifouling paints. Both primary exposure (rolling and spraying) and secondary exposure (during sand blasting) were studied....
article 2007
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Tielemans, E. (author), Warren, N. (author), Schneider, T. (author), Tischer, M. (author), Ritchie, P. (author), Goede, H. (author), Kromhout, H. (author), van Hemmen, J. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
REACH (Registration, Evaluation and Authorization of CHemicals) requires improved exposure models that can be incorporated into screening tools and refined assessment tools. These are referred to as tier 1 and 2 models, respectively. There are a number of candidate in tier 1 models that could be used with REACH. Tier 2 models, producing robust...
article 2007
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TNO Kwaliteit van Leven (author), Hertsenberg, S. (author), Brouwer, D. (author), Lurvink, M. (author), Rubingh, C. (author), Rijnders, E. (author), Tielemans, E. (author)
Self-assessment of exposure (SAE) refers to any exposure assessment methodology wherein the worker takes an active role in establishing his or her exposure status. The objective of this study was to investigate the reliability and feasibility of SAE approaches among shoe repair workers collecting exposure data over a 3 month period. This study...
article 2007
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Meijster, T. (author), Fransman, W. (author), van Hemmen, J. (author), Kromhout, H. (author), Heederik, D. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
Objective: The main goal was to investigate the potential of a probabilistic approach for exposure assessment and use this information to evaluate the impact of a complex of policy actions/interventions on dermal exposure to antineoplastic agents among oncology nurses. The central theme of this study was to make optimal use of existing data,...
article 2006
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Pronk, A. (author), Tielemans, E. (author), Skarping, G. (author), Bobeldijk, I. (author), van Hemmen, J. (author), Heederik, D. (author), Preller, L. (author), TNO Kwaliteit van Leven (author)
As part of a large-scale epidemiological study, occupational isocyanate exposure was assessed in spray-painting environments. The aim was to assess which compounds contribute to isocyanate exposure in car body repair shops and industrial painting companies, and to identify tasks with high risk of isocyanate exposure. Mainly personal task-based...
article 2006
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Meijster, T. (author), Tielemans, E. (author), de Pater, N. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Introduction: Recent studies have shown that even low exposure levels to flour dust and related allergens can cause severe respiratory symptoms. In The Netherlands the Dutch government and responsible branch organizations [from bakeries (traditional & industrial), flour mills and bakery ingredient producers] signed a covenant to reduce exposure...
article 2006
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Pronk, A. (author), Yu, F. (author), Vlaanderen, J. (author), Tielemans, E. (author), Preller, L. (author), Bobeldijk, I. (author), Deddens, J.A. (author), Latza, U. (author), Baur, X. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Objectives: To study inhalation and dermal exposure to hexamethylene diisocyanate (HDI) and its oligomers as well as personal protection equipment (PPE) use during task performance in conjunction with urinary hexamethylene diamine (HDA) in car body repair shop workers and industrial spray painters. Methods: Personal task based inhalation samples...
article 2006
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van Wendel de Joode, B. (author), Tielemans, E. (author), Vermeulen, R. (author), Wegh, H. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)
Charcoal cloth pads have been used to assess volatile chemicals on the skin in a laboratory setting; however, they have not yet been applied to measure dermal exposure in occupational settings. This study aimed at evaluating whether charcoal pads can be used to assess dermal exposure to benzene and toluene in workers of a petrochemical plant....
article 2005
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Gijsbers, J.H.J. (author), Tielemans, E. (author), Brouwer, D.H. (author), van Hemmen, J.J. (author), TNO Voeding (author)
Introduction: Limited quantitative information is available on dermal exposure to chemicals during various industrial activities. Therefore, within the scope of the EU-funded RISKOFDERM project, potential dermal exposure was measured during three different tasks: filling, loading and brushing. DEGBE (2-(2-butoxyethoxy)ethanol) was used as a ...
article 2004
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van der Jagt, K. (author), Tielemans, E. (author), Links, I. (author), Brouwer, D. (author), van Hemmen, J. (author), TNO Voeding (author)
This study assessed the effectiveness of a custom fit personal protective equipment (PPE) program aimed at reducing occupational exposure to pesticides. The intervention study was carried out on 15 pest control operators (PCOs) during mixing/loading and application of chlorpyrifos. Each worker was measured twice; first while the worker used PPE...
article 2004
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