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Rensen, H.B.H. (author), TNO Preventie en Gezondheid (author)
bookPart 1987
document
Rensen, H.B.H. (author), TNO Preventie en Gezondheid (author)
bookPart 1987
document
Rensen, H.B.H. (author), TNO Preventie en Gezondheid (author)
bookPart 1987
document
Rensen, M.B.H. (author)
bookPart 1991
document
Rensen, H.B.H. (author), TNO Preventie en Gezondheid (author)
bookPart 1987
document
Rensen, H.B.H. (author), TNO Preventie en Gezondheid (author)
bookPart 1987
document
Mooijaart, S.P. (author), van Vliet, P. (author), van Heemst, D. (author), Rensen, P.C.N. (author), Berbée, J.F.P. (author), Jolles, J. (author), de Craen, A.J.M. (author), Westendorp, R.G.J. (author), TNO Kwaliteit van Leven (author)
The relationship between structural variants of the apolipoprotein E gene, APOE ε2/ε3/ε4, and dementia is well established, whereas the relationship of plasma apoE levels with dementia is less clear. Plasma apoE levels are under tight genetic control but vary widely within the various genotypes indicating that the APOE ε2/ε3/ε4 locus explains...
bookPart 2007
document
Hirasing, R.A. (author), Rensen, H.B.H. (author), TNO Preventie en Gezondheid (author)
bookPart 1987
document
Rensen, H.B.H. (author), Hirasing, R.A. (author), TNO Preventie en Gezondheid (author)
bookPart 1987
document
Rensen, M.B.H. (author)
bookPart 1994
document
van Vliet, P. (author), Mooijaart, S.P. (author), de Craen, A.J.M. (author), Rensen, P.C.N. (author), van Heemst, D. (author), Westendorp, R.G.J. (author), TNO Kwaliteit van Leven (author)
Recently, high plasma apoE levels have been shown to be related to increased cardiovascular mortality, independent of APOE genotype. Here we studied the association of plasma apoE levels with risk of stroke. Within the Leiden 85-plus Study, a prospective population-based study of 561 subjects aged 85 years, we measured plasma apoE level and...
bookPart 2007
document
Rensen, H.B.H. (author), TNO Preventie en Gezondheid (author)
bookPart 1987
document
Geerling, J.J. (author), Boon, M.R. (author), van der Zon, G.C. (author), van den Berg, S.A.A. (author), van den Hoek, A.M. (author), Lombès, M. (author), Princen, H.M.G. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Guigas, B. (author)
Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-characterized antihyperglycemic properties, metformin also lowers plasma VLDL triglyceride (TG). In this study, we investigated the underlying mechanisms in APOE*3-Leiden.CETP mice, a well-established model for human-like lipoprotein metabolism. We found that...
article 2014
document
Gautier, T. (author), de Haan, W. (author), Grober, J. (author), Ye, D. (author), Bahr, M.J. (author), Claudel, T. (author), Nijstad, N. (author), van Berkel, T.J. (author), Havekes, L.M. (author), Manns, M.P. (author), Willems, S.M. (author), Hogendoorn, P.C. (author), Lagrost, L. (author), Kuipers, F. (author), van Eck, M. (author), Rensen, P.C. (author), Tietge, U.J. (author)
Cholesteryl ester transfer protein (CETP) activity results in a proatherogenic lipoprotein profi le. In cholestatic conditions, farnesoid X receptor (FXR) signaling by bile acids (BA) is activated and plasma HDL cholesterol (HDL-C) levels are low. This study tested the hypothesis that FXR-mediated induction of CETP contributes to this phenotype....
article 2013
document
Voshol, P.J. (author), Rensen, P.C.N. (author), van Dijk, K.W. (author), Romijn, J.A. (author), Havekes, L.M. (author), TNO Kwaliteit van Leven (author)
The obesity epidemic is associated with an increased incidence of type 2 diabetes, cardiovascular morbidity and various types of cancer. A better insight into the molecular mechanisms that underlie adipogenesis and obesity may result in novel therapeutic handles to fight obesity and these associated diseases. Adipogenesis is determined by the...
article 2009
document
Rensen, P.C.N. (author), van Dijk, K.W. (author), Havekes, L.M. (author), TNO Kwaliteit van Leven (author)
Chemicals / CAS: lipoprotein lipase, 83137-80-8, 9004-02-8; APOA5 protein, human; Apolipoproteins A; Apolipoproteins; Triglycerides
article 2005
document
de Haan, W. (author), de Vries-van der Weij, J. (author), Mol, I.M. (author), Hoekstra, M. (author), Romijn, J.A. (author), Jukema, J.W. (author), Havekes, L.M. (author), Princen, H.M.G. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)
Pregnane X receptor (PXR) agonism has been shown to affect multiple steps in both the synthesis and catabolism of HDL, but its integrated effect on HDL metabolism in vivo remains unclear. The aim of this study was to evaluate the net effect of PXR agonism on HDL metabolism in ApoE*3-Leiden (E3L) and E3L.CETP mice, well-established models for...
article 2009
document
de Haan, W. (author), Out, R. (author), Berbée, J.F.P. (author), van der Hoogt, C.C. (author), Dijk, K.W.v. (author), van Berkel, T.J.C. (author), Romijn, J.A. (author), Wouter Jukema, J. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)
Apolipoprotein CI (apoCI) has been suggested to influence HDL metabolism by activation of LCAT and inhibition of HL and CETP. However, the effect of apoCI on scavenger receptor BI (SR-BI)-mediated uptake of HDL-cholesteryl esters (CE), as well as the net effect of apoCI on HDL metabolism in vivo is unknown. Therefore, we evaluated the effect of...
article 2008
document
van den Berg, S.A.A. (author), Heemskerk, M.M. (author), Geerling, J.J. (author), van Klinken, J.B. (author), Schaap, F.G. (author), Bijland, S. (author), Berbée, J.F.P. (author), van Harmelen, V.J.A. (author), Pronk, A.C.M. (author), Schreurs, M. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), van Dijk, K.W. (author)
Mutations in apolipoprotein A5 (APOA5) have been associated with hypertriglyceridemia in humans and mice. This has been attributed to a stimulating role for APOA5 in lipoprotein lipase-mediated triglyceride hydrolysis and hepatic clearance of lipoprotein remnant particles. However, because of the low APOA5 plasma abundance, we investigated an...
article 2013
document
Westerterp, M. (author), van der Hoogt, C.C. (author), de Haan, W. (author), Offerman, E.H. (author), Dallinga-Thie, G.M. (author), Jukema, J.W. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE - The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate. Therefore, we evaluated the effect of human CETP expression on atherosclerosis in APOE*3-Leiden (E3L) mice with a humanized lipoprotein profile. METHODS AND RESULTS - E3L mice were crossbred with human CETP...
article 2006
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