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document
van der Laan, W.H. (author), Quax, P.H.A. (author), Seemayer, C.A. (author), Huisman, L.G.M. (author), Pieterman, E.J. (author), Grimbergen, J.M. (author), Verheijen, J.H. (author), Breedveld, F.C. (author), Gay, R.E. (author), Gay, S. (author), Huizinga, T.W.J. (author), Pap, T. (author), Gaubius Instituut TNO (author)
Matrix metalloproteinases (MMPs) are believed to be pivotal enzymes in the invasion of articular cartilage by synovial tissue in rheumatoid arthritis (RA). Here, we investigated the effects of gene transfer of tissue inhibitors of metalloproteinases (TIMPs) on the invasiveness of RA synovial fibroblasts (RASF) in vitro and in vivo. Adenoviral...
article 2003
document
Quax, P.H.A. (author), Lamfers, M.L.M. (author), Lardenoye, J.H.P. (author), Grimbergen, J.M. (author), de Vries, M.R. (author), Slomp, J. (author), de Ruiter, M.C. (author), Kockx, M.M. (author), Verheijen, J.H. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Background - Smooth muscle cell migration, in addition to proliferation, contributes to a large extent to the neointima formed in humans after balloon angioplasty or bypass surgery. Plasminogen activator/plasmin-mediated proteolysis is an important mediator of this smooth muscle cell migration. Here, we report the construction of a novel hybrid...
article 2001
document
van der Laan, W.H. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), TeKoppele, J.M. (author), Breedveld, F.C. (author), Gay, R.E. (author), Gay, S. (author), Huizinga, T.W.J. (author), Verheijen, J.H. (author), Quax, P.H.A. (author), Pap, T. (author), Gaubius Instituut TNO (author)
article 2000
document
van der Laan, W.H. (author), Pap, T. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), TeKoppele, J.M. (author), Breedveld, F.C. (author), Gay, R.E. (author), Gay, S. (author), Huizinga, T.W.J. (author), Verheijen, J.H. (author), Quax, P.H.A. (author)
article 2000
document
van der Laan, W.H. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), TeKoppele, J.M. (author), Huizinga, T.W.J. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Quax, P.H.A. (author), Gaubius Instituut TNO (author)
bookPart 1999
document
van der Laan, W.H. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), Breedveld, F.C. (author), te Koppele, J.M. (author), Huizinga, T.W.J. (author), Quax, P.H.A. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
article 1999
document
Quax, P.H.A. (author), Grimbergen, J.M. (author), Lansink, M. (author), Bakker, A.H.F. (author), Blatter, M.C. (author), Belin, D. (author), van Hinsbergh, V.W.M. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
Urokinase-type plasminogen activator (UPA), particularly when bound to its receptor (UPAR), is thought to play a major role in local proteolytic processes, thus facilitating cell migration as may occur during angiogenesis, neointima and atherosclerotic plaque formation, and tumor cell invasion. To facilitate understanding of the need and...
article 1998
document
Wijnberg, M.J. (author), Quax, P.H.A. (author), Nieuwenbroek, N.M.E. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
The plasminogen activation system is thought to be important in cell migration processes. A role for this system during smooth muscle cell migration after vascular injury has been suggested from several animal studies. However, not much is known about its involvement in human vascular remodelling. We studied the involvement of the plasminogen...
article 1997
document
Koopman, J.L. (author), Slomp, J. (author), de Bart, A.C.W. (author), Quax, P.H.A. (author), Verheijen, J.H. (author), TNO Preventie en gezondheid (author)
article 1996
document
Wijnberg, M.J. (author), Nieuwenbroek, N.M.E. (author), Slomp, J. (author), Quax, P.H.A. (author), Verheijen, J.H. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
The objective of this study was to investigate the role of the plasminogen activation system in the migration of human vascular smooth muscle cells in vitro. After wounding of confluent human smooth muscle cell cultures by stripping cells from their extracellular matrix, cells start to migrate from the wounded edge into the denuded area....
article 1996
document
Slomp, J. (author), Koopman, J.L. (author), Quax, P.H.A. (author), de Bart, A.C.W. (author), Hennius, B.C. (author), Nieuwenbroek, N.M.E. (author), Verheijen, J.H. (author), TNO Preventie en gezondheid (author)
abstract
article 1996
document
Quax, P.H.A. (author), Koolwijk, P. (author), Verheijen, J.H. (author), van Hinsbergh, V.W.M. (author), TNO Preventie en gezondheid (author)
bookPart 1996
document
Ronday, H.K. (author), Smits, H.H. (author), Quax, P.H.A. (author), van der Pluijm, G. (author), Löwik, C.W.G.M. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
article 1995
document
de Bart, A.C.W. (author), Quax, P.H.A. (author), Löwik, C.W.G.M. (author), Verheijen, J.H. (author), TNO Preventie en Gezondheid (author)
Plasmin-mediated extracellular proteolysis has been implicated in the degradation of bone in normal and pathological conditions. Normal and malignant osteoblasts can produce both tissue-type plasminogen activator (t- PA) and urokinase-type plasminogen activator (u-PA). We have used the osteosarcoma cell line MG63 to address the question of...
article 1995
document
Padro, T. (author), Quax, P.H.A. (author), van den Hoogen, C.M. (author), Roholl, P. (author), Verheijen, J.H. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
Plasminogen activator (PA) and PA inhibitor (PAI) antigen, activity, and mRNA were analyzed in the three layers of rat aorta, and the effect of endotoxin on PA and PAI was studied. All PA activity in aorta was identified as tissue-type PA (TPA) activity; no urokinase-type PA was detected. In the tunica adventitia TPA activity, TPA antigen, and...
article 1994
document
van Hinsbergh, V.W.M. (author), Quax, P.H.A. (author), Koolwijk, P. (author), Verheijen, J.H. (author), TNO Preventie en Gezondheid (author)
Abstract
article 1994
document
van Muijen, G.N.P. (author), de Vries, T.J. (author), Danen, E.H.J. (author), Quax, P. (author), Verheijen, J.H. (author), Ruiter, D.J. (author), TNO Preventie en Gezondheid (author)
In the pathogenesis qf human tumors the capacity of tumor cells to form metastases is one of the most crucial events. Ther^ore, the unravelling of molecular mechanisms involved in the process of metastasis is very important. Next to a great number of other factors, extracellular proteases and adhesion molecules of the integrin superfamily...
bookPart 1994
document
Quax, P.H.A. (author), van den Hoogen, M. (author), Verheijen, J.H. (author), Padro, T. (author), Zeheb, R. (author), Gelehrter, T.D. (author), van Berkel, T.J.C. (author), Kuiper, J. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The tissue-specific distribution of tissue-type and urokinase-type plasminogen activator (t-PA and u-PA) and their inhibitor type 1 (PAI-1) was analyzed at mRNA level in five major rat organ tissues. t-PA mRNA was detected in lung, kidney, heart, and liver. u-PA mRNA was detected in kidney and lung. Presence of PA mRNA correlated with the...
article 1990
document
Weening-Verhoeff, E.J.D. (author), Quax, P.H.A. (author), van Leeuwen, R.T.J. (author), Rehberg, E.F. (author), Marotti, K.R. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
article 1990
document
Quax, P.H.A. (author), van Leeuwen, R.T.J. (author), Verspaget, H.W. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
In 22 human tumor cell lines the regulation of production of plasminogen activators urokinase (u-PA) and tissue-type (u-PA) and their inhibitors PAI-1 and PAI-2 was studied. These four components may determine the net plasminogen activator activity, which is often associated with tumor development and metastatic processes. The amount of specific...
article 1990
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