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Knook, D.L. (author), Bosma, A. (author), Seifert, W.F. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
The relationship between vitamin A and liver fibrosis was studied with a CCl4-induced fibrosis model in rats. Depending on the time of administration, vitamin A can potentiate or reduce fibrosis: when present during CCl4-treatment parenchymal cell damage and fibrosis were enhanced, whereas vitamin A post-treatment strongly reduced fibrosis....
article 1995
Seifert, W.F. (author), Bosma, A. (author), Brouwer, A. (author), Hendriks, H.F.J. (author), Roholl, P.J.M. (author), van Leeuwen, R.E.W. (author), de Thiel van-Ruiter, G.C.F. (author), Seifert-Bock, I. (author), Knook, D.L. (author), TNO Preventie en Gezondheid (author)
Earlier studies have shown that retinoid administration suppresses the generation of hepatic fibrosis and stimulates its regression in normal (i.e., vitamin A-sufficient) carbon tetrachloride-treated rats. This study focuses on the possible role of a marginal or deficient vitamin A status on carbon tetrachloride-induced fibrosis. This...
article 1994
Knook, D.L. (author), Instituut voor experimentele gerontologie TNO (author)
Highly purified suspensions of parenchymal, endothelial and Kupffer cells were prepared from the rat liver. The respective roles of these cell classes in the degradation of proteins was investigated by analysing the cellular distribution of two lysomal proteases. The specific arginine naphthylamidase activity was 2 times higher in Kupffer cells...
article 1977