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Giltay, E.J. (author), Gooren, L.J.G. (author), Emeis, J.J. (author), Kooistra, T. (author), Stehouwer, C.D.A. (author), TNO Preventie en Gezondheid (author)
Oral estrogen administration decreases plasma levels of tissue-type plasminogen activator (tPA), which may be explained by a decrease in endothelial tPA synthesis, an increase in its hepatic clearance, or both. In the present study, we determined (1) differences between oral (ie, via the liver) ethinyl estradiol and transdermal (ie, systemic)...
article 2000
document
Nieuwenhuys, C.M.A. (author), Béguin, S. (author), Offermans, R.F.G. (author), Emeis, J.J. (author), Hornstra, G. (author), Heemskerk, J.W.M. (author), Gaubius Instituut TNO (author)
We investigated the effects of dietary polyunsaturated fatty acids (PUFAs) on blood lipids and processes that determine hemostatic potential: platelet activation, coagulation, and fibrinolysis. For 8 to 10 weeks, Wistar rats were fed a high-fat diet containing various amounts (2% to 16%) of n-3 PUFAs derived from fish oil (FO) or a diet enriched...
article 1998
document
Kooistra, T. (author), Lansink, M. (author), Emeis, J.J. (author), TNO Preventie en Gezondheid (author)
Chemicals/CAS: 4 [2 (5,6,7,8 tetrahydro 5,5,8,8 tetramethyl 2 naphthyl) 1 propenyl]benzoic acid, 71441-28-6; butyric acid, 107-92-6, 156-54-7, 461-55-2; cyclic AMP, 60-92-4; protein kinase C, 141436-78-4; retinoic acid, 302-79-4; tissue plasminogen activator, 105913-11-9; trichostatin A, 58880-19-6
article 1996
document
Kooistra, T. (author), Schrauwen, Y. (author), Arts, J. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The fibrinolytic activity of blood is to a large extent determined by the plasma level of tissue-type plasminogen activator (t-PA). Changes in the plasma level of t-PA are mainly achieved by the endothelium by two mechanisms: (a) a rapid, short-term release of t-PA, which occurs within minutes (acute release, regulated secretion) and (b) a long...
article 1994
document
Tranquille, N. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The acute release of tissue-type plasminogen activator (t-PA) was studied in perfused rat hindlegs. Pretreatment of rats with the protein synthesis inhibitor cycloheximide (2 mg/kg) at 1, 3 or 5 h prior to perfusion of rat hindlegs did not influence the amount of t-PA released by platelet-activating factor (20 nM) or bradykinin (1 μM). The...
article 1989
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