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Lindeman, J.H.N. (author), Ashcroft, B.A. (author), Beenakker, J.-W.M. (author), van Es, M. (author), Koekkoek, N.B.R. (author), Prins, F.A. (author), Tielemans, J.F. (author), Abdul-Hussien, H. (author), Bank, R.A. (author), Oosterkamp, T.H. (author), TNO Kwaliteit van Leven (author)
An aneurysm of the aorta is a common pathology characterized by segmentalweakeningof the artery.Althoughit isgenerally accepted that the vessel-wall weakening is caused by an impaired collagen metabolism, a clear association has been demonstrated only for rare syndromes such as the vascular type Ehlers-Danlos syndrome. Here we show that vessel...
article 2010
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van Deemter, M. (author), Ponsioen, T.L. (author), Bank, R.A. (author), Snabel, J.M.M. (author), van der Worp, R.J. (author), Hooymans, J.M.M. (author), Los, L.I. (author), TNO Kwaliteit van Leven (author)
article 2010
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Willems, N.M.B.K. (author), Langenbach, G.E.J. (author), Everts, V. (author), Mulder, L. (author), Grünheid, T. (author), Bank, R.A. (author), Zentner, A. (author), van Eijden, T.M.G.J. (author), TNO Kwaliteit van Leven (author)
Collagen is an important constituent of bone, and it has been suggested that changes in collagen and mineral properties of bone are interrelated during growth. The aim of this study was to quantify age-related changes in collagen properties and the degree of mineralization of bone (DMB). The DMB in cancellous and cortical bone samples from the...
article 2010
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Fernandes, H. (author), Mentink, A. (author), Bank, R. (author), Stoop, R. (author), van Blitterswijk, C. (author), de Boer, J. (author), TNO Kwaliteit van Leven (author)
Human multipotent mesenchymal stromal cells (hMSCs) are multipotent cells that, in the presence of appropriate stimuli, can differentiate into different lineages such as the osteogenic, chondrogenic, and adipogenic lineages. In the presence of ascorbic acid, MSCs secrete an extracellular matrix mainly composed of collagen type I. Here we...
article 2010
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van Deemter, M. (author), Ponsioen, T.L. (author), Bank, R.A. (author), Snabel, J.M.M. (author), van der Worp, R.J. (author), Hooymans, J.M.M. (author), Los, L.I. (author), TNO Kwaliteit van Leven (author)
article 2010
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Rubbens, M.P. (author), Mol, A. (author), Boerboom, R.A. (author), Bank, R.A. (author), Baaijens, F.P.T. (author), Bouten, C.V.C. (author), TNO Industrie en Techniek TNO Kwaliteit van Leven (author)
Tissue-engineered heart valves lack sufficient amounts of functionally organized structures and consequently do not meet in vivo mechanical demands. To optimize tissue architecture and hence improve mechanical properties, various in vitro mechanical conditioning protocols have been proposed, of which intermittent straining is most promising in...
article 2009
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Rubbens, M.P. (author), Mol, A. (author), van Marion, M.H. (author), Hanemaaijer, R. (author), Bank, R.A. (author), Baaijens, F.P.T. (author), Bouten, C.V.C. (author), TNO Kwaliteit van Leven (author)
Similar to native cardiovascular tissues, the mechanical properties of engineered cardiovascular constructs depend on the composition and quality of the extracellular matrix, which is a net result of matrix remodeling processes within the tissue. To improve tissue remodeling, and hence tissue mechanical properties, various mechanical...
article 2009
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van Deemter, M. (author), Ponsioen, T.L. (author), Bank, R.A. (author), Snabel, J.M.M. (author), van der Worp, R.J. (author), Hooymans, J.M.M. (author), Los, L.I. (author), TNO Kwaliteit van Leven (author)
The human vitreous body undergoes structural changes with aging. This can be followed by a posterior vitreous detachment, which can result in ocular pathology. As in many collagenous tissues, age-related changes in the vitreous could be caused by the formation of advanced glycation end products (AGEs). The goal of this study was to find out...
article 2009
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Balguid, A. (author), Mol, A. (author), van Marion, M.H. (author), Bank, R.A. (author), Bouten, C.V.C. (author), Baaijens, F.P.T. (author), TNO Kwaliteit van Leven (author)
Despite the attractive features of nanofibrous scaffolds for cell attachment in tissue-engineering (TE) applications, impeded cell ingrowth has been reported in electrospun scaffolds. Previous findings have shown that the scaffold can function as a sieve, keeping cells on the scaffold surface, and that cell migration into the scaffold does not...
article 2009
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Knippenberg, M. (author), Helder, M.N. (author), Doulabi, B.Z. (author), Bank, R.A. (author), Wuisman, P.I.J.M. (author), Klein-Nulend, J. (author), TNO Kwaliteit van Leven (author)
Adipose tissue-derived mesenchymal stem cells (AT-MSCs) in combination with bone morphogenetic protein-2 (BMP-2) or transforming growth factor-β1 (TGF-β1) are under evaluation for bone tissue engineering. Posttranslational modification of type I collagen is essential for functional bone tissue with adequate physical and mechanical properties. We...
article 2009
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Ponsioen, T.L. (author), van Deemter, M. (author), Bank, R.A. (author), Snabel, J.M. (author), Zijlstra, G.S. (author), van der Worp, R.J. (author), Hooymans, J.M.M. (author), Los, L.I. (author), TNO Kwaliteit van Leven (author)
article 2009
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Lu, Z.F. (author), Doulabi, B.Z. (author), Huang, C.L. (author), Bank, R.A. (author), Helder, M.N. (author), TNO Kwaliteit van Leven (author)
β1 integrins play a controversial role during chondrogenesis. Since the maturation of chondrocytes relies on a signaling switch from cell-cell to cell-matrix interactions, we hypothesized that β1 integrins play a different role at the earlier (mainly cell-cell interaction) from the later stage (mainly cell-matrix interaction) of chondrogenesis....
article 2008
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Lu, Z.F. (author), Zandieh Doulabi, B. (author), Huang, C.L. (author), Bank, R.A. (author), Helder, M.N. (author), TNO Kwaliteit van Leven (author)
article 2008
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Hoogendoorn, R.J.W. (author), Helder, M.N. (author), Wuisman, P.I.J.M. (author), Bank, R.A. (author), Everts, V.E. (author), Smit, T.H. (author), TNO Kwaliteit van Leven (author)
article 2008
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Hoogendoorn, R.J.W. (author), Helder, M.N. (author), Kroeze, R.J. (author), Bank, R.A. (author), Smit, T.H. (author), Wuisman, P.I.J.M. (author), TNO Kwaliteit van Leven (author)
STUDY DESIGN. Twelve goats were chemically degenerated and the development of the degenerative signs was followed for 26 weeks to evaluate the progression of the induced degeneration. The results were also compared with a previous study to determine the reproducibility. OBJECTIVES. The purpose of this study was determine whether this...
article 2008
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Hoogendoorn, R. (author), Doulabi, B.Z. (author), Huang, C.L. (author), Wuisman, P.I. (author), Bank, R.A. (author), Helder, M.N. (author), TNO Kwaliteit van Leven (author)
Study Design. Caprine lumbar intervertebral discs (IVD) were collected from previous studies and categorized as normal, mildly, or severely degenerated. The biochemical composition and the RNA profiles present in both the nucleus pulposus (NP) and the anulus fibrosus (AF) were analyzed. Objective. To determine the molecular changes occurring in...
article 2008
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van den Bos, T. (author), Speijer, D. (author), Bank, R.A. (author), Bromme, D. (author), Everts, V. (author), TNO Kwaliteit van Leven (author)
article 2008
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Balguid, A. (author), Rubbens, M.P. (author), Mol, A. (author), Bank, R.A. (author), Bogers, A.J.J.C. (author), van Kats, J.P. (author), de Mol, B.A.J.M. (author), Baaijens, F.P.T. (author), Bouten, C.V.C. (author), TNO Kwaliteit van Leven (author)
A major challenge in tissue engineering of functional heart valves is to determine and mimic the dominant tissue structures that regulate heart valve function and in vivo survival. In native heart valves, the anisotropic matrix architecture assures sustained and adequate functioning under high-pressure conditions. Collagen, being the main load...
article 2007
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Lu, Z.F. (author), Zandieh Doulabi, B. (author), Wuisman, P.I. (author), Bank, R.A. (author), Helder, M.N. (author), TNO Kwaliteit van Leven (author)
Degenerative disc disease (DDD) is a major cause of chronic low back pain. For mild/intermediate DDD, regeneration by injecting adipose stem cells (ASCs) into the nucleus pulposus (NP) may be considered. The goal of this study is to investigate whether NP cells can direct ASCs towards the NP phenotype. Interactions between NP cells and ASCs were...
article 2007
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Steenvoorden, M.M.C. (author), Bank, R.A. (author), Ronday, H.K. (author), Toes, R.E.M. (author), Huizinga, T.W.J. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)
Objective: In vitro models for joint diseases often focus on a single cell type, such as chondrocytes in osteoarthritis (OA) or fibroblast-like synoviocytes (synoviocytes) in rheumatoid arthritis (RA). However, these joint diseases affect the whole joint and interaction between chondrocytes and synoviocytes may play an important role in disease...
article 2007
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