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te Koppele, J.M. (author), Beekman, B. (author), Meulenbelt, I. (author), Bank, R.A. (author), Slagboom, P.E. (author), TNO Preventie en Gezondheid (author)
bookPart 1993
document
te Koppele, J.M. (author), Bank, R.A. (author), Bayliss, M.T. (author), Gaubius Instituut TNO (author)
Osteoarthritis (OA) is a multifac{orial chronic disease with high incidence and prevalence in the elderly. Age is a major risk facto/ in the occurrence ol OA. ln the populatĀ”on, few individuals suffer from 'early onset OA'. The maiority of individuals have 'late onset OA', whereas a minority of elderly lacks OA. Such a profile is comparable to...
conference paper 1995
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Bank, R.A. (author), Jansen, E.J. (author), Beekman, B. (author), te Koppele, J.M. (author), Gaubius Instituut TNO (author)
article 1996
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Bank, R.A. (author), Krikken, M. (author), Beekman, B. (author), Stoop, R. (author), Maroudas, A. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author)
article 1997
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Beekman, B. (author), Verzijl, N. (author), Bank, R.A. (author), Von Der Mark, K. (author), TeKoppele, J.M. (author), TNO Preventie en Gezondheid (author)
The extracellular matrix synthesized by articular chondrocytes cultured in alginate beads was investigated. Collagen levels increased sigmoidally with time and remained constant after 2 weeks of culture. The presence of cartilage-specific type II collagen was confirmed immunohistochemically. Predominantly type H collagen was present in the...
article 1997
document
Bank, R.A. (author), Beekman, B. (author), Tenni, R. (author), Tekoppele, J.M. (author), Gaubius Instituut TNO (author)
Measurement of the glycosylated hydroxylysines galactosyl- and glucosylgalactosylhydroxylysine (GH and GGH) in combination with other amino acids has been based on ion-exchange chromatography followed by reaction with ninhydrin. Here, a rapid and sensitive high-performance liquid chromatographic method with fluorimetric detection has been...
article 1997
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Bank, R.A. (author), Beekman, B. (author), Verzijl, N. (author), de Roos, J.A.D.M. (author), Nico Sakkee, A. (author), Tekoppele, J.M. (author), TNO Preventie en Gezondheid (author)
A high-performance liquid chromatographic assay was developed for pyridinium crosslinks and pentosidine in mature collagen of a wide variety of connective tissue hydrolysates by a simple two-step isocratic assay using a reversed-phase column. The crosslinks (including the internal standard pyridoxine) were optimally detected by their native...
article 1997
document
Basser, P.J. (author), Schneiderman, R. (author), Bank, R.A. (author), Wachtel, E. (author), Maroudas, A. (author), TNO Preventie en Gezondheid (author)
We have used an isotropic osmotic stress technique to assess the swelling pressures of human articular cartilage over a wide range of hydrations in order to determine from these measurements, for the first time, the tensile stress in the collagen network, P(c), as a function of hydration. Osmotic stress was applied by means of calibrated...
article 1998
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Kleter, G.A. (author), Damen, J.J.M. (author), van den Kettenes-Bosch, J.J. (author), Bank, R.A. (author), te Koppele, J.M. (author), Veraart, J.R. (author), ten Cate, J.M. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The aim was to identify suspect collagen cross-links in dentine, eluting close to known cross-links in ion-exchange HPLC. Bovine tooth roots as source of dentine were powdered, demineralised, reduced, and acid-hydrolysed. Cross-linking amino acids were isolated from the acid hydrolysate by size exclusion, adsorption, and sequential ion exchange...
article 1998
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Bank, R.A. (author), Bayliss, M.T. (author), Lafeber, F.P.J.G. (author), Maroudas, A. (author), Tekoppele, J.M. (author), Gaubius Instituut TNO (author)
A biomechanical failure of the collagen network is postulated in many hypotheses of the development of osteoarthritis with advancing age. Here we investigate the accumulation of non-enzymatic glycation (NEG) products in healthy human articular cartilage, its relation to tissue remodelling and its role in tissue stiffening. Pentosidine levels...
article 1998
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't Hart, B.A. (author), Bank, R.A. (author), de Roos, J.A.D.M. (author), Brok, H. (author), Jonker, M. (author), Theuns, H.M. (author), Hakimi, J. (author), Koppele, J.M.Te. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The objective of this study was to analyse parameters in rhesus monkey collagen-induced arthritis (CIA) with which the inflammation and destruction of the joints can be described in quantitative terms. CIA was induced in genetically susceptible and resistant monkeys, which can be distinguished on the basis of the dominant resistance marker Mamu...
article 1998
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TeKoppele, J.M. (author), Beekman, B. (author), Verzijl, N. (author), Koopman, J.L. (author), de Groot, J. (author), Bank, R.A. (author), Gaubius Instituut TNO (author)
Doxycycline (DOX) profoundly inhibited collagen synthesis by differentiated articular chondrocytes. At 25 microM, the rate of collagen synthesis was suppressed by more than 50% without affecting cell proliferation (DNA levels) and general protein synthesis (35S-Met and 35S-Cys incorporation). Steady-state mRNA levels of type II collagen were...
article 1998
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Bank, R.A. (author), TeKoppele, J.M. (author)
conference paper 1999
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Chen, C.-T. (author), Burton-Wurster, N. (author), Lust, G. (author), Bank, R.A. (author), Tekoppele, J.M. (author)
The first objective of this study was to determine if the cumulative effects of impact or smoothly arising compression would damage the matrix of articular cartilage. Canine cartilage explants were subjected to repeated impacts or to smoothly arising compressions of as much as 20 MPa at 0.3 Hz for as long as 120 minutes. An increase in the water...
article 1999
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van den Nieuwendijk, A.M.C.H. (author), Benningshof, J.C.J. (author), Wegmann, V. (author), Bank, R.A. (author), TeKoppele, J.M. (author), Brussee, J. (author), van der Gen, A. (author)
article 1999
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Brama, P.A.J. (author), TeKoppele, J.M. (author), Bank, R.A. (author), van Weeren, P.R. (author), Barneveld, A. (author)
article 1999
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Brama, P.A.J. (author), TeKoppele, J.M. (author), Bank, R.A. (author), van Weeren, P.R. (author), Barneveld, A. (author), Dept. of Gen. and Large Anim. Surg., Faculty of Veterinary Medicine, Utrecht 3584CM, Netherlands Div. Vasc. Connective Tissue Res., Gaubius Laboratory, TNO Prevention and Health, Leiden 2301CE, Netherlands (author)
Objective - To determine variations in biochemical characteristics of equine articular cartilage in relation to age and the degree of predisposition for osteochondral disease at a specific site. Sample Population - Articular cartilage specimens from 53 horses 4 to 30 years old. Procedure - Healthy specimens were obtained from 2 locations on the...
article 1999
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Bank, R.A. (author), te Koppele, J.M. (author)
Swelling of cartilage, one of the early signs of osteoarthritis (OA), is considered to be the result of a collagen network that has lost its integrity. So far, no quantitative data directly support this assertion: combined measurements of the state of the collagen network per se and the degree of swelling are lacking. Degraded collagen molecules...
article 1999
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Bank, R.A. (author), Robins, S.P. (author), Wijmenga, C. (author), Breslau-Siderius, L.J. (author), Bardoel, A.F.J. (author), van der Sluijs, H.A. (author), Pruijs, H.E.H. (author), Tekoppele, J.M. (author)
Bruck syndrome is characterized by the presence of osteoporosis, joint contractures, fragile bones, and short stature. We report that lysine residues within the telopeptides of collagen type I in bone are underhydroxylated, leading to aberrant crosslinking, but that the lysine residues in the triple helix are normally modified. In contrast to...
article 1999
document
van den Nieuwendijk, A.M.C.H. (author), Benningshof, J.C.J. (author), Wegmann, V. (author), Bank, R.A. (author), te Koppele, J.M. (author), Brussee, J. (author), van der Gen, A. (author), TNO Preventie en Gezondheid (author)
A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis.
article 1999
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