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van Beek, L. (author), Feron, V.J. (author), de Groot, A.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Alkali treated spun soy isolate was fed to rats at dietary levels of 5, 10, and 20% for a period of 90 days. The results failed to reveal any adverse effects on general appearance, growth, feeding efficiency, hematological indices, blood serum values, urine composition, kidney function, organ weights, and gross and microscopic pathology except...
article 1974
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Kruysse, A. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)
The inhalation toxicity of peroxyacetyl nitrate (PAN) was examined in acute (single exposure), subacute (4-wk repeated exposure) and subchronic (13-wk repeated exposure) studies in rats. The 4-hr LC50 was found to be 95 ppm. In the 4-wk study rats were exposed to 0, 0.9, 4.1 or 11.8 ppm PAN vapor for 6 hr/day, 5 days/wk. Exposure to 11.8 ppm...
article 1977
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Feron, V.J. (author), Kruysse, A. (author), Til, H.P. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)
The subacute inhalation toxicity of acrolein was examined in 4 groups of 20 hamsters, 12 rats and 4 rabbits each, exposed repeatedly to acrolein vapour at concentrations of 0, 0.4, 1.4 and 4.9 ppm (6 hr/day, 5 days/week) for a 13-week period. The most important effects found at the highest level included mortality in rats, ocular and nasal...
article 1978
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Feron, V.J. (author), Kruysse, A. (author), Immel, H.R. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, salivation, nasal discharge,...
article 1979
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Feron, V.J. (author), van den Heuvel, P.D. (author), Koeter, H.B.W.M. (author), Beems, R.B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1980
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Feron, V.J. (author), Hendriksen, C.F.M. (author), Speek, A.J. (author), Til, H.P. (author), Spit, B.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A lifespan oral toxicity of vinyl chloride monomer (VCM) was carried out in Wistar rats, using five groups each of 60-80 males and 60-80 females. VCM was administered by incorporating polyvinyl chloride (PVC) powder with a high VCM content into the diet or by gastric intubation of a 10% VCM solution in soya-bean oil. The VCM doses (actual...
article 1981
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Feron, V.J. (author), Kruysse, A. (author), Woutersen, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Syrian golden hamsters were exposed to 0 or 2500-1650 ppm acetaldehyde vapour, 7 hr/day, 5 days/week for a period of 52 weeks. A proportion of the animals was given, simultaneously, either intratracheal instillations of benzo(a)pyrene (BP) or subcutaneous injections of diethylnitrosamine (DENA). All treatments were stopped after 52 weeks. The...
article 1982
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Beems, R.B. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Chemicals/CAS: benzo[a]pyrene, 50-32-8; retinol, 68-26-8, 82445-97-4; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Vitamin A, 11103-57-4
article 1984
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Centraal Instituut voor Voedingsonderzoek TNO (author), Beems, R.B. (author), van Beek, L. (author)
Chemicals/CAS: benzo[a]pyrene, 50-32-8; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Carcinogens; Dietary Fats; Fatty Acids, Unsaturated.
article 1984
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Reynders, J.B.J. (author), Immel, H.R. (author), Scherrenberg, P.M. (author), Feron, V.J. (author), Beems, R.B. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Two groups of male and female Syrian golden hamsters, of which the trachea was severely injured by electrocoagulation, received 6 weekly intratracheal instillations of benzo[a]pyrene (BaP) + ferric oxide in saline or saline alone. Two comparable groups of hamsters were similarly treated but had an undamaged trachea. The experiment was terminated...
article 1985
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Janssen, P.J.M. (author), Bosland, M.C. (author), van Hees, J.P. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The effects of feeding inorganic tin on the gastrointestinal tract were examined in rats. Three groups of male weanling Wistar rats were fed a diet to which 0, 250, or 500 ppm Sn2+ had been added as SnCl2. A fourth group was subjected to feed restriction by pair feeding with the 500-ppm group. Comparison of the data from the tin-fed groups with...
article 1985
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Centraal Instituut voor Voedingsonderzoek TNO (author), Kool, H.J. (author), Kuper, F. (author), van Haeringen, H. (author), Koeman, J.H. (author)
The carcinogenicity in male and female Wistar SSP TOX rats of organic drinking-water concentrates that are positive in the Ames test was studied at thr. Chemicals/CAS: Carcinogens, Environmental; Mutagens; Water Pollutants; Water Pollutants, Chemical.
article 1985
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Til, H.P. (author), Feron, V.J. (author), Immel, H.R. (author), Vogel, W.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), Woutersen, R.A. (author), Appelman, L.M. (author), van Garderen-Hoetmer, A. (author), Feron, V.J. (author)
Male and female Wistar rats were exposed to acetaldehyde vapour at nominal concentrations 0, 750, 1500 or 3000/1000 ppm during 6 h/day, 5 days/week for up to 28 months. Major compound-related effects included increased mortality, growth retardation, nasal tumours, and non-neoplastic nasal changes in each of the test groups. The treatment-related...
article 1986
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Hooftman, R.N. (author), Kuper, C.F. (author), Appelman, L.M. (author), Hoofdgroep Maatschappelijke Technologie TNO (author)
The sensitivity of different parameters for the determination of lung injury caused by nitrogen dioxide (NO2) was investigated. Male rats were exposed to concentrations of 0, 4, 10 or 25 ppm NO2 for 6 h/day, for 7, 14 or 21 days. Histopathology of the nasal cavity, larynx, trachea and lungs was compared with the changes in macrophage function...
article 1988
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van Poppel, G. (author), Schrijver, J. (author), Meulmeester, J.F. (author), Kempen-Voogd, N. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: Cholesterol, 57-88-5; Iron, 7439-89-6; Vitamins
article 1989
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Centraal Instituut voor Voedingsonderzoek TNO Instituut voor Landbouwkundig Onderzoek van Biochemische Produkten TNO (author), Huisman, J. (author), van der Poel, A.F.B. (author), van Leeuwen, P. (author), Verstegen, M.W.A. (author)
The effects of lectins in the diet have been mainly studied in rats. An important question is whether results obtained in rats can be extrapolated to larger animals like the pig. Phaseolus vulgaris beans are rich in toxic lectins. Therefore a study was carried out to compare the effects of diets containing 200 g Phaseolus vulgaris beans (raw or...
article 1990
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Centraal Instituut voor Voedingsonderzoek TNO (author), Lina, B.A.R. (author), Dreef-Van Der Meulen, H.C. (author), Leegwater, D.C. (author)
Neohesperidin dehydrochalcone was administered to groups of 20 male and 20 female Wistar rats at dietary levels of 0, 0.2, 1.0 and 5.0% for 91 days. No treatment-related ophthalmoscopical, haematological or histopathological effects were observed. In the high-dose group, a marked caecal enlargement occurred in both sexes, accompanied by soft...
article 1990
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Gaubius Instituut TNO (author), de Knijff, P. (author), van den Maagdenberg, A.M.J.M. (author), Stalenhoef, A.F.H. (author), Leuven, J.A.G. (author), Demacker, P.N.M. (author), Kuyt, L.P. (author), Frants, R.R. (author), Havekes, L.M. (author)
By the careful screening of familial dysbetalipoproteinemic (FD) patients, five probands showing heterozygosity for the APOE*3-Leiden allele were found. Genealogical studies revealed that these probands share common ancestry in the 17th century. In a group of 128 family members, spanning three generations, 37 additional heterozygous APOE*3...
article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Poppel, G.van. (author), Schneijder, P. (author), Löwik, M.R.H. (author), Schrijver, J. (author), Kok, F.J. (author)
As part of the Dutch Nutrition Surveillance System, cardiovascular risk factors and food consumption (24 h recall) as well as haematological, Fe and vitamin status (A, B6, C) were assessed in 126 Dutch boys aged 10-11 years (response 71%). Body mass index (BMI) and the sum of four skinfolds were strongly associated (r 0.85, P < 0.01) and 8% of...
article 1991
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