Searched for: +
(1 - 20 of 2,098)

Pages

document
Kuper, C.F. (author), Bosland, M.C. (author)
article 2019
document
Pali-Scholl, I. (author), Blank, S. (author), Verhoeckx, K. (author), Mueller, R.S. (author), Janda, J. (author), Marti, E. (author), Seida, A.A. (author), Rhyner, C. (author), DeBoer, D.J. (author), Jensen-Jarolim, E. (author)
Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, and compare reactions in companion...
article 2019
document
Kubbinga, M. (author), Augustijns, P. (author), Garcia, M.A. (author), Heinen, C. (author), Wortelboer, H.M. (author), Verwei, M. (author), Langguth, P. (author)
Chitosan is object of pharmaceutical research as a candidate permeability enhancer. However, chitosan was recently shown to reduce the oral bioavailability of acyclovir in humans. The effect of chitosan on two processes determining the oral bioavailability of acyclovir, bioaccessibility and intestinal absorption, was now investigated. Acyclovir...
article 2019
document
Mirahmadi, F. (author), Koolstra, J.H. (author), Fazaeli, S. (author), Lobbezoo, F. (author), van Lenthe, G.H. (author), Snabel, J. (author), Stoop, R. (author), Everts, V. (author)
Nutrition of articular cartilage relies mainly on diffusion and convection of solutes through the interstitial fluid due to the lack of blood vessels. The diffusion is controlled by two factors: steric hindrance and electrostatic interactions between the solutes and the matrix components. Aging comes with changes in the cartilage structure and...
article 2019
document
Tans, R. (author), Verschuren, L. (author), Wessels, H.J.C.T. (author), Bakker, S.J.L. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)
Introduction: The onset of type 2 diabetes mellitus (T2DM) is strongly associated with obesity and subsequent perturbations in immuno-metabolic responses. To understand the complexity of these systemic changes and better monitor the health status of people at risk, validated clinical biomarkers are needed. Omics technologies are increasingly...
article 2019
document
Butler, J. (author), Hens, B. (author), Vertzoni, M. (author), Brouwers, J. (author), Berben, P. (author), Dressman, J. (author), Andreas, C.J. (author), Schaefer, K.J. (author), Mann, J. (author), McAllister, M. (author), Jamei, M. (author), Kostewicz, E. (author), Kesisoglou, F. (author), Langguth, P. (author), Minekus, M. (author), Müllertz, A. (author), Schilderink, R. (author), Koziolek, M. (author), Jedamzik, P. (author), Weitschies, W. (author), Reppas, C. (author), Augustijns, P. (author)
The availability of in vitro tools that are constructed on the basis of a detailed knowledge of key aspects of gastrointestinal (GI) physiology and their impact on formulation performance and subsequent drug release behaviour is fundamental to the success and efficiency of oral drug product development. Over the last six years, the development...
article 2019
document
Kozijn, A.E. (author), Gierman, L.M. (author), van der Ham, F. (author), Mulder, P. (author), Morrison, M.C. (author), Kühnast, S. (author), van der Heijden, R.A. (author), Stavro, P.M. (author), van Koppen, A. (author), Pieterman, E.J. (author), van den Hoek, A.M. (author), Kleemann, R. (author), Princen, H.M.G. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author), Zuurmond, A.M. (author), Bobeldijk, I. (author), Weinans, H. (author), Stoop, R. (author)
Objective. Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the mechanisms underlying this metabolic phenotype of OA, we examined cartilage degradation in the knees of mice from different genetic backgrounds in which a metabolic phenotype was...
article 2018
document
Fiamoncini, J. (author), Rundle, M. (author), Gibbons, H. (author), Thomas, E.L. (author), Geillinger-Kästle, K. (author), Bunzel, D. (author), Trezzi, J.P. (author), Kiselova-Kaneva, Y. (author), Wopereis, S. (author), Wahrheit, J. (author), Kulling, S.E. (author), Hiller, K. (author), Sonntag, D. (author), Ivanova, D. (author), van Ommen, B. (author), Frost, G. (author), Brennan, L. (author), Bell, J. (author), Daniel, H. (author)
Health has been defined as the capability of the organism to adapt to challenges. In this study,we tested to what extent comprehensively phenotyped individuals reveal differences in metabolic responses to a standardized mixed meal tolerance test (MMTT) and how these responses change when individuals experience moderate weight loss. Metabolome...
article 2018
document
Fuijkschot, W.W. (author), Morrison, M.C. (author), Zethof, I.P.A. (author), Krijnen, P.A.J. (author), Kleemann, R. (author), Niessen, H.W.M. (author), Smulders, Y.M. (author)
Background and Aims: Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intraplaque inflammation. We evaluated whether...
article 2018
document
Mirahmadi, F. (author), Koolstra, J.H. (author), Lobbezoo, F. (author), van Lenthe, G.H. (author), Ghazanfari, S. (author), Snabel, J. (author), Stoop, R. (author), Everts, V. (author)
Objective: Aging is accompanied by a series of changes in mature tissues that influence their properties and functions. Collagen, as one of the main extracellular components of cartilage, becomes highly crosslinked during aging. In this study, the aim was to examine whether a correlation exists between collagen crosslinking induced by artificial...
article 2018
document
Vo-Thanh, N. (author), Jans, R. (author), Schoen, E.D. (author), Goos, P. (author)
Two-level orthogonal designs play an important role in industrial screening experiments, in which the primary goal is to identify the treatment factors with the largest main effects on the output of a process or the performance of a product. Often, the experimental tests suggested by the orthogonal designs cannot be performed on a single day or...
article 2018
document
van de Steeg, E. (author), Schuren, F.H.J. (author), Obach, R.S. (author), van Woudenbergh, C. (author), Walker, G.S. (author), Heerikhuisen, M. (author), Nooijen, I.H.G. (author), Vaes, W.H.J. (author)
Colon microbiota-based drug metabolism has received little attention thus far in the process of drug development, whereas the role of gut microbiota in clinical safety and efficacy of drugs has become more clear. Many of these studies have been performed using animal studies, but the translational value of these data with respect to drug...
article 2018
document
Botschuijver, S. (author), Welting, O. (author), Levin, E. (author), Maria-Ferreira, D. (author), Koch, E. (author), Montijn, R.C. (author), Seppen, J. (author), Hakvoort, T.B.M. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), van den Wijngaard, R.M. (author)
Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder associated with altered gastrointestinal microflora and increased nociception to colonic distension. This visceral hypersensitivity can be reversed in our rat maternal separation model by fungicides. Menthacarin® is a proprietary combination of essential oils from...
article 2018
document
Mirahmadi, F. (author), Koolstra, J.H. (author), Fazaeli, S. (author), Lobbezoo, F. (author), van Lenthe, G.H. (author), Snabel, J. (author), Stoop, R. (author), Arbabi, V. (author), Weinans, H. (author), Everts, V. (author)
Objective Aging can cause an increase in the stiffness of hyaline cartilage as a consequence of increased protein crosslinks. By induction of crosslinking, a reduction in the diffusion of solutions into the hyaline cartilage has been observed. However, there is a lack of knowledge about the effects of aging on the biophysical and biochemical...
article 2018
document
Bressot, C. (author), Shandilya, N. (author), Jayabalan, T. (author), Fayet, G. (author), Voetz, M. (author), Meunier, L. (author), Le Bihan, O. (author), Aguerre-Chariol, O. (author), Morgeneyer, M. (author)
Characterization of the exposition to nanoparticles and nano-objects at workplaces is a huge technical challenge. Workplace exposure during short durations is particularly difficult to detect due to the low performances of the samplers. This article proposes a solution allowing for characterizing emissions at workplaces and presents the results...
article 2018
document
Hakouk, K. (author), Klotz, M. (author), Di Geronimo, E. (author), Ranieri, V. (author), Pieterse, J.A.Z. (author), Aranda Almansa, G. (author), Steele, A.M. (author), Thorpe, S. (author)
The conversion of hydrocarbons contained in product gas from medium-temperature biomass gasification into syngas is a crucial step to improve the overall process energy efficiency of biofuel production. Catalytic steam reforming is an attractive option; however, deactivation by tar and carbon deposition is one of the main challenges of steam...
article 2018
document
Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)
Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...
article 2018
document
Omardien, S. (author), ter Beek, A. (author), Vischer, N. (author), Montijn, R. (author), Schuren, F. (author), Brul, S. (author)
An empirical approach was taken to screen a novel synthetic compound library designed to be active against Gram-positive bacteria. We obtained five compounds that were active against spores from the model organism Bacillus subtilis and the food-borne pathogen Bacillus cereus during our population based experiments. Using single cell live imaging...
article 2018
document
Collins, S.L. (author), McMillan, A. (author), Seney, S. (author), van der Veer, C. (author), Kort, R. (author), Sumarah, M.W. (author), Reid, G. (author)
Perturbations to the vaginal microbiota can lead to dysbiosis, including bacterial vaginosis (BV), which affects a large portion of the female population. In a healthy state, the vaginal microbiota is characterized by low diversity and colonization by Lactobacillus spp., whereas in BV, these species are displaced by a highly diverse population...
article 2018
document
Pouwer, M.G. (author), Pieterman, E.J. (author), Verschuren, L. (author), Caspers, M.P.M. (author), Kluft, C. (author), Garcia, R.A. (author), Aman, J. (author), Jukema, J.W. (author), Princen, H.M.G. (author)
Treatment with the second and third generation BCR-ABL1 tyrosine kinase inhibitors (TKIs) increases cardiovascular risk in chronic myeloid leukemia (CML) patients. We investigated the vascular adverse effects of three generations of TKIs in a translational model for atherosclerosis, the APOE*3Leiden.CETP mouse. Mice were treated for sixteen...
article 2018
Searched for: +
(1 - 20 of 2,098)

Pages