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Huisman, L.G.M. (author), Meijer, P. (author), van Griensven, J. (author), Kluft, C. (author), Gaubius Laboratory Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
t-PA depleted citrated plasma was used to prepare standards of different molecular forms of plasminogen activator inhibitor 1 (PAI-1). These standards were used to evaluate the specificity of two new PAI-1 antigen assays: the TintElize PAI-1 antigen assay (cat. no. 210221) and the Innotest PAI-1. Differences in specificity were apparent: the...
article 1992
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Mpofu, A. (author), Linnemann, A.R. (author), Sybesma, W. (author), Kort, R. (author), Nout, M.J.R. (author), Smid, E.J. (author)
A probiotic dairy product was developed on the basis of a traditional dish called mutandabota to enable resource-poor populations in southern Africa to benefit from a functional food. Mutandabota is widely consumed in rural southern Africa, making it an ideal food matrix to carry probiotics. First, a process to produce probiotic mutandabota was...
article 2014
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van der Bas, J.M.A. (author), Quax, P.H.A. (author), van den Berg, A.C. (author), van Hinsbergh, V.W.M. (author), van Bockel, J.H. (author), Gaubius Instituut TNO (author)
Objective: One of the most life-threatening vascular diseases is rupture of an abdominal aneurysm. The conventional treatment is based on surgical reconstruction. An alternative treatment is endovascular aneurysm repair (EVAR). Despite many advantages, one of the problems of EVAR is endoleakage from deficient healing between the aortic neck and...
article 2002
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Nowack, B. (author), David, R.M. (author), Fissan, H. (author), Morris, H. (author), Shatkin, J.A. (author), Stintz, M. (author), Zepp, R. (author), Brouwer, D. (author)
The expected widespread use of carbon nanotube (CNT)-composites in consumer products calls for an assessment of the possible release and exposure to workers, consumers and the environment. Release of CNTs may occur at all steps in the life cycle of products, but to date only limited information is available about release of CNTs from actual...
article 2013
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Shandilya, N. (author), Morgeneyer, M. (author), Le Bihan, O. (author)
In this work, the particle aerosols emissions during the abrasion of three products – brick, wood and stainless steel – are measured. Owing to different material removal mechanisms in these three products during their abrasions, different quantities and generation rates of aerosols are observed with the brick producing the highest number at a...
article 2015
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de Sonneville, L.M.J. (author), Huijbregts, S.C.J. (author), van Spronsen, F.J. (author), Verkerk, P.H. (author), Sergeant, J.A. (author), Licht, R. (author), TNO Kwaliteit van Leven (author)
This study focused on important characteristics of attentional (selective) processing in children with early-treated phenylketonuria (PKU). Seven to 14-year-old children with PKU were allocated to high phenylalanine (Phe) and low Phe groups and compared with control children on amplitudes and latencies of early and late event-related potential ...
article 2009
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Hennis, B.C. (author), Boomsma, D.I. (author), van Boheemen, P.A. (author), Engesser, L. (author), Kievit, P. (author), Dooijewaard, G. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
A pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levels of HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an age effect of 3% and an effect of individual...
article 1995
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Visser, F. (author), Miller, P.J.O. (author), Antunes, R.N. (author), Oudejans, M.G. (author), Mackenzie, M.L. (author), Aoki, K. (author), Lam, F.P.A. (author), Kvadsheim, P.H. (author), Huisman, J. (author), Tyack, P.L. (author)
Long-finned pilot whales (Globicephala melas) are highly social cetaceans that live in matrilineal groups and acquire their prey during deep foraging dives. We tagged individual pilot whales to record their diving behaviour. To describe the social context of this individual behaviour, the tag data were matched with surface observations at the...
article 2014
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Aten, J.B.T. (author), Medisch Biologisch Laboratorium TNO (author)
article 1984
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Ramirez, T. (author), Daneshian, M. (author), Kamp, H. (author), Bois, F.Y. (author), Clench, M.R. (author), Coen, M. (author), Donley, B. (author), Fischer, S.M. (author), Ekman, D.R. (author), Fabian, E. (author), Guillou, C. (author), Heuer, J. (author), Hogberg, H.T. (author), Jungnickel, H. (author), Keun, H.C. (author), Krennrich, G. (author), Krupp, E. (author), Luch, A. (author), Noor, F. (author), Peter, E. (author), Riefke, B. (author), Seymour, M. (author), Skinner, N. (author), Smirnova, L. (author), Verheij, E. (author), Wagner, S. (author), Hartung, T. (author), van Ravenzwaay, B. (author), Leist, M. (author)
Metabolomics, the comprehensive analysis of metabolites in a biological system, provides detailed information about the biochemical/physiological status of a biological system, and about the changes caused by chemicals. Metabolomics analysis is used in many fields, ranging from the analysis of the physiological status of genetically modified...
article 2013
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Brama, P.A.J. (author), Tekoppele, J.M. (author), Bank, R.A. (author), Karssenberg, D. (author), Barneveld, A. (author), van Weeren, P.R. (author)
The aim of this study was to evaluate topographical differences in the biochemical composition of the extracellular matrix of articular cartilage of the normal equine fetlock joint. Water content, DNA content, glycosaminoglycan (GAG) content and a number of characteristics of the collagen network (total collagen content, levels of hydroxylysine-...
article 2000
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Geerling, J.J. (author), Boon, M.R. (author), van der Zon, G.C. (author), van den Berg, S.A.A. (author), van den Hoek, A.M. (author), Lombès, M. (author), Princen, H.M.G. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Guigas, B. (author)
Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-characterized antihyperglycemic properties, metformin also lowers plasma VLDL triglyceride (TG). In this study, we investigated the underlying mechanisms in APOE*3-Leiden.CETP mice, a well-established model for human-like lipoprotein metabolism. We found that...
article 2014
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van den Eijnden-Schrauwen, Y. (author), Lakenberg, N. (author), Emeis, J.J. (author), de Knijff, P. (author), TNO Preventie en Gezondheid (author)
article 1995
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Hollander, C.F. (author), Instituut voor experimentele gerontologie TNO (author)
article 1981
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Jansen, N.W.D. (author), Roosendaal, G. (author), Bijlsma, J.W.J. (author), de Groot, J. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)
Objective. Joint bleeding, or hemarthrosis, leads in time to severe joint damage. This study was carried out to test the in vitro thresholds of exposure time and concentration that lead to irreversible joint damage, to add to the discussion on the usefulness of aspiration of the joint after a hemorrhage. Methods. Explants of healthy human...
article 2007
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Slagboom, P.E. (author), Zurcher, C. (author), TNO Preventie en Gezondheid (author)
article 1993
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Al-Lahham, S.H. (author), Peppelenbosch, M.P. (author), Roelofsen, H. (author), Vonk, R.J. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
Undigested food is fermented in the colon by the microbiota and gives rise to various microbial metabolites. Short-chain fatty acids (SCFA), including acetic, propionic and butyric acid, are the principal metabolites produced. However, most of the literature focuses on butyrate and to a lesser extent on acetate; consequently, potential effects...
article 2010
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Smokovitis, A. (author), Astrup, T. (author), Gaubius instituut TNO (author)
Fibrinolytic activity (caused by a plasminogen activator) in the spinal cord was highest in the rat, lowest in the rabbit, and intermediate in the guinea pig. In all species the activity was highest in relation to the pia mater. The central spinal canal was active in the rat and the rabbit, but mostly inactive in the guinea pig. Foci of activity...
article 1978
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de Jonge, A. (author), van der Goes, B.Y. (author), Ravelli, A.C.J. (author), Amelink-Verburg, M.P. (author), Mol, B.W. (author), Nijhuis, J.G. (author), Bennebroek Gravenhorst, J. (author), Buitendijk, S.E. (author), TNO Kwaliteit van Leven (author)
article 2009
document
Wensinck, F. (author), Medisch Biologisch Laboratorium TNO (author)
article 1961
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