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- Kuper, C.F. (author), Bosland, M.C. (author) article 2019
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Pali-Scholl, I. (author), Blank, S. (author), Verhoeckx, K. (author), Mueller, R.S. (author), Janda, J. (author), Marti, E. (author), Seida, A.A. (author), Rhyner, C. (author), DeBoer, D.J. (author), Jensen-Jarolim, E. (author)Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, and compare reactions in companion...article 2019
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Kubbinga, M. (author), Augustijns, P. (author), Garcia, M.A. (author), Heinen, C. (author), Wortelboer, H.M. (author), Verwei, M. (author), Langguth, P. (author)Chitosan is object of pharmaceutical research as a candidate permeability enhancer. However, chitosan was recently shown to reduce the oral bioavailability of acyclovir in humans. The effect of chitosan on two processes determining the oral bioavailability of acyclovir, bioaccessibility and intestinal absorption, was now investigated. Acyclovir...article 2019
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Mirahmadi, F. (author), Koolstra, J.H. (author), Fazaeli, S. (author), Lobbezoo, F. (author), van Lenthe, G.H. (author), Snabel, J. (author), Stoop, R. (author), Everts, V. (author)Nutrition of articular cartilage relies mainly on diffusion and convection of solutes through the interstitial fluid due to the lack of blood vessels. The diffusion is controlled by two factors: steric hindrance and electrostatic interactions between the solutes and the matrix components. Aging comes with changes in the cartilage structure and...article 2019
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Tans, R. (author), Verschuren, L. (author), Wessels, H.J.C.T. (author), Bakker, S.J.L. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)Introduction: The onset of type 2 diabetes mellitus (T2DM) is strongly associated with obesity and subsequent perturbations in immuno-metabolic responses. To understand the complexity of these systemic changes and better monitor the health status of people at risk, validated clinical biomarkers are needed. Omics technologies are increasingly...article 2019
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Butler, J. (author), Hens, B. (author), Vertzoni, M. (author), Brouwers, J. (author), Berben, P. (author), Dressman, J. (author), Andreas, C.J. (author), Schaefer, K.J. (author), Mann, J. (author), McAllister, M. (author), Jamei, M. (author), Kostewicz, E. (author), Kesisoglou, F. (author), Langguth, P. (author), Minekus, M. (author), Müllertz, A. (author), Schilderink, R. (author), Koziolek, M. (author), Jedamzik, P. (author), Weitschies, W. (author), Reppas, C. (author), Augustijns, P. (author)The availability of in vitro tools that are constructed on the basis of a detailed knowledge of key aspects of gastrointestinal (GI) physiology and their impact on formulation performance and subsequent drug release behaviour is fundamental to the success and efficiency of oral drug product development. Over the last six years, the development...article 2019
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Kozijn, A.E. (author), Gierman, L.M. (author), van der Ham, F. (author), Mulder, P. (author), Morrison, M.C. (author), Kühnast, S. (author), van der Heijden, R.A. (author), Stavro, P.M. (author), van Koppen, A. (author), Pieterman, E.J. (author), van den Hoek, A.M. (author), Kleemann, R. (author), Princen, H.M.G. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author), Zuurmond, A.M. (author), Bobeldijk, I. (author), Weinans, H. (author), Stoop, R. (author)Objective. Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the mechanisms underlying this metabolic phenotype of OA, we examined cartilage degradation in the knees of mice from different genetic backgrounds in which a metabolic phenotype was...article 2018
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Fiamoncini, J. (author), Rundle, M. (author), Gibbons, H. (author), Thomas, E.L. (author), Geillinger-Kästle, K. (author), Bunzel, D. (author), Trezzi, J.P. (author), Kiselova-Kaneva, Y. (author), Wopereis, S. (author), Wahrheit, J. (author), Kulling, S.E. (author), Hiller, K. (author), Sonntag, D. (author), Ivanova, D. (author), van Ommen, B. (author), Frost, G. (author), Brennan, L. (author), Bell, J. (author), Daniel, H. (author)Health has been defined as the capability of the organism to adapt to challenges. In this study,we tested to what extent comprehensively phenotyped individuals reveal differences in metabolic responses to a standardized mixed meal tolerance test (MMTT) and how these responses change when individuals experience moderate weight loss. Metabolome...article 2018
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Fuijkschot, W.W. (author), Morrison, M.C. (author), Zethof, I.P.A. (author), Krijnen, P.A.J. (author), Kleemann, R. (author), Niessen, H.W.M. (author), Smulders, Y.M. (author)Background and Aims: Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intraplaque inflammation. We evaluated whether...article 2018
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Mirahmadi, F. (author), Koolstra, J.H. (author), Lobbezoo, F. (author), van Lenthe, G.H. (author), Ghazanfari, S. (author), Snabel, J. (author), Stoop, R. (author), Everts, V. (author)Objective: Aging is accompanied by a series of changes in mature tissues that influence their properties and functions. Collagen, as one of the main extracellular components of cartilage, becomes highly crosslinked during aging. In this study, the aim was to examine whether a correlation exists between collagen crosslinking induced by artificial...article 2018
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Vo-Thanh, N. (author), Jans, R. (author), Schoen, E.D. (author), Goos, P. (author)Two-level orthogonal designs play an important role in industrial screening experiments, in which the primary goal is to identify the treatment factors with the largest main effects on the output of a process or the performance of a product. Often, the experimental tests suggested by the orthogonal designs cannot be performed on a single day or...article 2018
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van de Steeg, E. (author), Schuren, F.H.J. (author), Obach, R.S. (author), van Woudenbergh, C. (author), Walker, G.S. (author), Heerikhuisen, M. (author), Nooijen, I.H.G. (author), Vaes, W.H.J. (author)Colon microbiota-based drug metabolism has received little attention thus far in the process of drug development, whereas the role of gut microbiota in clinical safety and efficacy of drugs has become more clear. Many of these studies have been performed using animal studies, but the translational value of these data with respect to drug...article 2018
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Mirahmadi, F. (author), Koolstra, J.H. (author), Fazaeli, S. (author), Lobbezoo, F. (author), van Lenthe, G.H. (author), Snabel, J. (author), Stoop, R. (author), Arbabi, V. (author), Weinans, H. (author), Everts, V. (author)Objective Aging can cause an increase in the stiffness of hyaline cartilage as a consequence of increased protein crosslinks. By induction of crosslinking, a reduction in the diffusion of solutions into the hyaline cartilage has been observed. However, there is a lack of knowledge about the effects of aging on the biophysical and biochemical...article 2018
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Bressot, C. (author), Shandilya, N. (author), Jayabalan, T. (author), Fayet, G. (author), Voetz, M. (author), Meunier, L. (author), Le Bihan, O. (author), Aguerre-Chariol, O. (author), Morgeneyer, M. (author)Characterization of the exposition to nanoparticles and nano-objects at workplaces is a huge technical challenge. Workplace exposure during short durations is particularly difficult to detect due to the low performances of the samplers. This article proposes a solution allowing for characterizing emissions at workplaces and presents the results...article 2018
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Implementation of novel ice-templated materials for conversion of tars from gasification product gasHakouk, K. (author), Klotz, M. (author), Di Geronimo, E. (author), Ranieri, V. (author), Pieterse, J.A.Z. (author), Aranda Almansa, G. (author), Steele, A.M. (author), Thorpe, S. (author)The conversion of hydrocarbons contained in product gas from medium-temperature biomass gasification into syngas is a crucial step to improve the overall process energy efficiency of biofuel production. Catalytic steam reforming is an attractive option; however, deactivation by tar and carbon deposition is one of the main challenges of steam...article 2018
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Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...article 2018
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Omardien, S. (author), ter Beek, A. (author), Vischer, N. (author), Montijn, R. (author), Schuren, F. (author), Brul, S. (author)An empirical approach was taken to screen a novel synthetic compound library designed to be active against Gram-positive bacteria. We obtained five compounds that were active against spores from the model organism Bacillus subtilis and the food-borne pathogen Bacillus cereus during our population based experiments. Using single cell live imaging...article 2018
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Collins, S.L. (author), McMillan, A. (author), Seney, S. (author), van der Veer, C. (author), Kort, R. (author), Sumarah, M.W. (author), Reid, G. (author)Perturbations to the vaginal microbiota can lead to dysbiosis, including bacterial vaginosis (BV), which affects a large portion of the female population. In a healthy state, the vaginal microbiota is characterized by low diversity and colonization by Lactobacillus spp., whereas in BV, these species are displaced by a highly diverse population...article 2018
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Pouwer, M.G. (author), Pieterman, E.J. (author), Verschuren, L. (author), Caspers, M.P.M. (author), Kluft, C. (author), Garcia, R.A. (author), Aman, J. (author), Jukema, J.W. (author), Princen, H.M.G. (author)Treatment with the second and third generation BCR-ABL1 tyrosine kinase inhibitors (TKIs) increases cardiovascular risk in chronic myeloid leukemia (CML) patients. We investigated the vascular adverse effects of three generations of TKIs in a translational model for atherosclerosis, the APOE*3Leiden.CETP mouse. Mice were treated for sixteen...article 2018
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Wambaugh, J.F. (author), Hughes, M.F. (author), Ring, C.L. (author), MacMillan, D.K. (author), Ford, J. (author), Fennell, T.R. (author), Black, S.R. (author), Snyder, R.W. (author), Sipes, N.S. (author), Wetmore, B.A. (author), Westerhout, J. (author), Setzer, R.W. (author), Pearce, R.G. (author), Simmons, J.E. (author), Thomas, R.S. (author)Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable. Relatively high throughput, in vitro TK (HTTK) assays and in vitro-to-in vivo extrapolation (IVIVE) methods have been developed to predict TK, but most of the in vivo...article 2018