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van Berkel, S.R. (author), Prevoo, M.J.L. (author), Linting, M. (author), Pannebakker, F.D. (author), Alink, L.R.A. (author)
BACKGROUND: The third Netherlands' Prevalence study of Maltreatment of children and youth (NPM-2017) continues the tradition of periodically mapping the national prevalence of child maltreatment. OBJECTIVE: The NPM-2017 provides an update of the current prevalence rates of child maltreatment and of changes in its prevalence over the last 12...
article 2020
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Alink, L.R.A. (author), Prevoo, M.J.L. (author), van Berkel, S.R. (author), Lingting, M. (author), Pannebakker, F. (author)
In het eerste nummer van Kind en Adolescent dat dit jaar op de (digitale) deurmat viel, schreven Van der Put en Assink (2017) over de Nationale Prevalentiestudie Mishandeling van kinderen en jeugdigen (NPM). Het Wetenschappelijk Onderzoek- en Documentatiecentrum (WODC) heeft ons, namens het ministerie van Veiligheid en Justitie, de opdracht...
article 2017
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Alink, L.R.A. (author), Prevoo, M.J.L. (author), van Berkel, S.R. (author), Lingting, M. (author), Pannebakker, F. (author)
Wij danken Van der Put en Assink (2017) voor de waardering die zij uitspreken voor de uitvoering van de Nationale Prevalentiestudies Mishandeling van kinderen en jeugdigen (NPM). Overigens presenteren wij in onze reactie geen nieuwe gegevens, maar gegevens die al in 2013 zijn gepubliceerd (Euser et al. 2013). Van der Put en Assink komen terug op...
article 2017
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Alink, L.R.A. (author), Pannebakker, F. (author), Prevoo, M.J.L. (author), van Berkel, S.R. (author), Linting, M. (author), Bakermans-Kranenburg, M. (author), Vogels, T. (author), Euser, S. (author), van IJzerdoorn, R. (author)
In zijn artikel in het NJB concludeert Peter Prinsen dat het resultaat van de meest recente Nationale Prevalentiestudie Mishandeling van kinderen en jeugdigen (119.000 slachtoffers van kindermishandeling in één jaar tijd) een drastische overschatting is van het werkelijke aantal mishandelde kinderen. Daarmee zou dit resultaat onbruikbaar zijn...
article 2017
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Bhattacharjee, S. (author), Marcelis, A.T.M. (author), Zuilhof, H. (author), Woutersen, R.A. (author), Rietjens, I.M.C.M. (author), Alink, G.M. (author)
Tri-block copolymer nanoparticles (TCNP) are increasingly utilized, especially in drug delivery and diagnostics platforms. From in vitro studies, surface charge was observed to influence the transport of TCNP across the Caco-2 monolayers grown on transwell inserts. The objective of this study was to investigate the influence of surface charge on...
article 2013
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Euser, S. (author), Alink, L.R.A. (author), Pannebakker, F. (author), Vogels, T. (author), Bakermans-Kranenburg, M.J. (author), van IJzendoorn, M.H. (author)
The prevalence of child maltreatment in the Netherlands was in 2005 first systematically examined in the Netherlands’ Prevalence study on Maltreatment of children and youth (NPM-2005), using sentinel reports and substantiated CPS cases, and in the Pupils on Abuse study (PoA-2005), using high school students’ self-report. In this second National...
article 2013
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Alink, L. (author), Pannebakker, F. (author), Euser, S. (author), Bakermans-Kranenburg, M. (author), Vogels, T. (author), van IJzendoorn, R. (author)
The current study assesses the year prevalence of child maltreatment in the Netherlands. We estimated the prevalence of sexual, physical, and emotional abuse and physical and emotional neglect using different methods: informant-, CPS-, and self-reports. We also tested which family and demographic factors increased the risk for child maltreatment...
article 2013
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Schutte, M.E. (author), Alink, G.M. (author), Freidig, A.P. (author), Spenkelink, B. (author), Vaessen, J.C.H. (author), van de Sandt, J.J.M. (author), Groten, J.P. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author), KvL (author)
This study investigates whether the previous observation that quercetin increases the transport of PhIP through Caco-2 monolayers in vitro could be confirmed in an in vivo rat model. Co-administration of 1.45 μmol PhIP/kg bw and 30 μmol quercetin/kg bw significantly increased the blood AUC(0-8 h) of PhIP in rats to 131 ± 14% of the AUC(0-8 h)...
article 2008
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Dihal, A.A. (author), van der Woude, H. (author), Hendriksen, P.J.M. (author), Charif, H. (author), Dekker, L.J. (author), IJsselstijn, L. (author), de Boer, V.C.J. (author), Alink, G.M. (author), Burgers, P.C. (author), Rietjens, I.M.C.M. (author), Woutersen, R.A. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author), KvL (author)
Quercetin has been shown to act as an anticarcinogen in experimental colorectal cancer (CRC). The aim of the present study was to characterize transcriptome and proteome changes occurring in the distal colon mucosa of rats supplemented with 10 g quercetin/kg diet for 11 wk. Transcriptome data analyzed with Gene Set Enrichment Analysis showed...
article 2008
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Dihal, A.A. (author), de Boer, V.C.J. (author), van der Woude, H. (author), Tilburgs, C. (author), Bruijntjes, J.P. (author), Alink, G.M. (author), Rietjens, I.M.C.M. (author), Woutersen, R.A. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)
The effect of the flavonoid quercetin and its conjugate rutin was investigated on (biomarkers of) colorectal cancer (CRC). Male F344 rats (n = 42/group) were fed 0, 0.1, 1, or 10 g quercetin/kg diet or 40 g rutin/kg diet. Two wk after initial administration of experimental diets, rats were given 2 weekly subcutaneous injections with 15 mg/kg...
article 2006
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Jeurissen, S.M.F. (author), Bogaards, J.J.P. (author), Boersma, M.G. (author), ter Horst, J.P.F. (author), Awad, H.M. (author), Fiamegos, Y.C. (author), van Beek, T.A. (author), Alink, G.M. (author), Sudhölter, E.J.R. (author), Cnubben, N.H.P. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)
In vitro studies were performed to elucidate the human cytochrome P450 enzymes involved in the bioactivation of methyleugenol to its proximate carcinogen 1′-hydroxymethyleugenol. Incubations with Supersomes, expressing individual P450 enzymes to a high level, revealed that P450 1A2, 2A6, 2C9, 2C19, and 2D6 are intrinsically able to 1′...
article 2006
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Schutte, M.E. (author), Freidig, A.P. (author), van de Sandt, J.J.M. (author), Alink, G.M. (author), Rietjens, I.M.C.M. (author), Groten, J.P. (author), TNO Kwaliteit van Leven (author)
The present study describes the effect of different flavonoids on the absorption of the pro-carcinogen PhIP through Caco-2 monolayers and the development of an in silico model describing this process taking into account passive diffusion and active transport of PhIP. Various flavonoids stimulated the apical to basolateral PhIP transport. Using...
article 2006
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Schutte, M.E. (author), van de Sandt, J.J.M. (author), Alink, G.M. (author), Groten, J.P. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)
The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was...
article 2006
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de Boer, V.C.J. (author), Dihal, A.A. (author), van der Woude, H. (author), Arts, I.C.W. (author), Wolffram, S. (author), Alink, G.M. (author), Rietjens, I.M.C.M. (author), Keijer, J. (author), Hollman, P.C.H. (author), TNO Kwaliteit van Leven (author)
Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health. Claims that quercetin has biological effects are based mainly on in vitro studies with quercetin aglycone. However, quercetin is rapidly metabolized, and we have little knowledge of its availability to tissues. To assess the long-term tissue distribution...
article 2005
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Jeurissen, S.M.F. (author), Bogaards, J.J.P. (author), Awad, H.M. (author), Boersma, M.G. (author), Brand, W. (author), Fiamegos, Y.C. (author), van Beek, T.A. (author), Alink, G.M. (author), Sudhölter, E.J.R. (author), Cnubben, N.H.P. (author), Rietjens, I.M.C.M. (author), TNO Voeding (author)
In the present study, the cytochrome P450 mediated bioactivation of safrole to its proximate carcinogenic metabolite, 1′-hydroxysafrole, has been investigated for the purpose of identifying the human P450 enzymes involved. The 1′-hydroxylation of safrole was characterized in a variety of in vitro test systems, including Supersomes, expressing...
article 2004
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Dommels, Y.E.M. (author), Haring, M.M.G. (author), Keestra, N.G.M. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author)
This study was conducted to investigate the role of the enzyme cyclooxygenase (COX) and its prostaglandin product PGE2 in n-6 and n-3 polyunsaturated fatty acid (PUFA)-mediated effects on cellular proliferation of two human colorectal carcinoma cell lines. The long chain PUFAs eicosapentaenoic acid (EPA; 20:5n-3) and arachidonic acid (AA; 20:4n...
article 2003
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Dommels, Y.E.M. (author), Heemskerk, S. (author), van den Berg, H. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author)
Modulating effects of high fat fish oil (HFFO) and high fat corn oil (HFCO) diets on azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were studied in male F344 rats following 8 weeks of dietary treatment. The incidence of AOM-induced ACF was significantly lower in the proximal colon of rats fed the HFFO diets compared with rats fed...
article 2003
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Dommels, Y.E.M. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author), TNO Voeding (author)
During the past few decades, many studies have been conducted to evaluate the effects of n-6 and n-3 polyunsaturated fatty acids (PUFAs) on colorectal carcinogenesis. This report provides a brief overview of the recent studies that have been performed in cultured colon cells, animal models as well as of the population-based and short-term...
article 2002
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Dommels, Y.E.M. (author), Alink, G.M. (author), Linssen, J.P.H. (author), van Ommen, B. (author), TNO Voeding (author)
article 2002
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Rietjens, I.M.C.M. (author), Boersma, M.G. (author), de Haan, L. (author), Spenkelink, B. (author), Awad, H.M. (author), Cnubben, N.H.P. (author), van Zanden, J.J. (author), van der Woude, H. (author), Alink, G.M. (author), Koeman, J.H. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Natural antioxidants like vitamin C, vitamin E, carotenoids, and polyphenols like flavonoids, are at present generally considered to be beneficial components from fruit and vegetables. The anti-oxidative properties of these compounds are often claimed to be responsible for various beneficial health effects of these food ingredients. Together...
article 2002
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