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document
Beekman, Z.M. (author)
A study concerning a defined population in the Netherlands
doctoral thesis 1962
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Medisch Biologisch Laboratorium TNO (author), Blok, J. (author), Aten, J.B.T. (author), Beekman, Z.M. (author), Beijerinck, D. (author), Bosnjakovic, B.F.M. (author), Davids, J.A.G. (author), Kal, H.B. (author), van Kempen, R.J. (author), Konings, A.W.T. (author), Lohman, P.H.M. (author), Pauwels, E.K.J. (author), Philippens, M.N.E.J.G. (author), Schaake-Koning, C.C.E. (author), Vos, O. (author), Passchier, W.F. (author), Schoten, E.J. (author)
report 1988
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te Koppele, J.M. (author), Beekman, B. (author), Meulenbelt, I. (author), Bank, R.A. (author), Slagboom, P.E. (author), TNO Preventie en Gezondheid (author)
bookPart 1993
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te Koppele, J.M. (author), Beekman, B. (author), Bloemhoff, W. (author), Drijfhout, J.W. (author), TNO Preventie en Gezondheid (author)
article 1995
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te Koppele, J.M. (author), Verzijl, N. (author), Beekman, B. (author), TNO Preventie en Gezondheid (author)
Abstract
conference paper 1995
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Bank, R.A. (author), Jansen, E.J. (author), Beekman, B. (author), te Koppele, J.M. (author), Gaubius Instituut TNO (author)
article 1996
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van Osch, G.J.V.M. (author), van den Berg, W.B. (author), te Koppele, J.M. (author), van der Kraan, P.M. (author), Beekman, B. (author), Homminga, G.N. (author), Häuselmann, H.J. (author), TNO Preventie en Gezondheid (author)
conference paper 1996
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Böhm, B.B. (author), Beekman, B. (author), Drijfhout, J.W. (author), te Koppele, J.M. (author), Gaubius Instituut TNO (author)
conference paper 1996
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Gaubius Instituut TNO (author), Beekman, B. (author), Drijfhout, J.W. (author), Bloemhoff, W. (author), Ronday, H.K. (author), Tak, P.P. (author), TeKoppele, J.M. (author)
article 1996
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Bank, R.A. (author), Krikken, M. (author), Beekman, B. (author), Stoop, R. (author), Maroudas, A. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author)
article 1997
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van Valburg, A.A. (author), Wenting, M.J.G. (author), Beekman, B. (author), TeKoppele, J.M. (author), Lafeber, F.P.G.J. (author), Bijlsma, J.W.J. (author)
article 1997
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Beekman, B. (author), Verzijl, N. (author), Bank, R.A. (author), Von Der Mark, K. (author), TeKoppele, J.M. (author), TNO Preventie en Gezondheid (author)
The extracellular matrix synthesized by articular chondrocytes cultured in alginate beads was investigated. Collagen levels increased sigmoidally with time and remained constant after 2 weeks of culture. The presence of cartilage-specific type II collagen was confirmed immunohistochemically. Predominantly type H collagen was present in the...
article 1997
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Bank, R.A. (author), Beekman, B. (author), Tenni, R. (author), Tekoppele, J.M. (author), Gaubius Instituut TNO (author)
Measurement of the glycosylated hydroxylysines galactosyl- and glucosylgalactosylhydroxylysine (GH and GGH) in combination with other amino acids has been based on ion-exchange chromatography followed by reaction with ninhydrin. Here, a rapid and sensitive high-performance liquid chromatographic method with fluorimetric detection has been...
article 1997
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Bank, R.A. (author), Beekman, B. (author), Verzijl, N. (author), de Roos, J.A.D.M. (author), Nico Sakkee, A. (author), Tekoppele, J.M. (author), TNO Preventie en Gezondheid (author)
A high-performance liquid chromatographic assay was developed for pyridinium crosslinks and pentosidine in mature collagen of a wide variety of connective tissue hydrolysates by a simple two-step isocratic assay using a reversed-phase column. The crosslinks (including the internal standard pyridoxine) were optimally detected by their native...
article 1997
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Beekman, B. (author), Verzijl, N. (author), de Roos, J.A.D.M. (author), Koopman, J.L. (author), Tekoppele, J.M. (author), Leiden, Netherlands Gaubius Instituut TNO (author)
Doxycycline is known for its ability to inhibit matrix metalloproteinases (MMPs), a family of enzymes that play a role in cartilage breakdown in arthritides. Its prophylactic effect in reducing joint degradation in osteoarthritis is mainly attributed to this property. In this study, we show that doxycycline exhibits a profound inhibition of...
article 1997
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Gaubius Instituut TNO (author), Verheijen, J.H. (author), Nieuwenbroek, N.M.E. (author), Beekman, B. (author), Hanemaaijer, R. (author), Verspaget, H.W. (author), Ronday, K.H. (author), Bakker, A.H.F. (author)
We describe a new principle for assessment of the activity of proteolytic enzymes of all classes and show the application of this principle for the quantitative assay of bacterial collagenase and human matrix metalloproteinases (MMPs). Central to this new principle is the presence of a proenzyme that can be activated into an active enzyme by a...
article 1997
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Gaubius Instituut TNO (author), Beekman, B. (author), van El, B. (author), Drijfhout, J.W. (author), Ronday, H.K. (author), TeKoppele, J.M. (author)
Stromelysin-1 (MMP-3) is an important member of the matrix metalloproteinase family. In joint-degrading diseases like arthritis, elevated levels of MMP-3 protein are detected in synovial fluid using immunological methods. However, these methods do not discriminate between active and inactive enzyme. In the present study, a specific stromelysin...
article 1997
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TeKoppele, J.M. (author), Beekman, B. (author), Verzijl, N. (author), Koopman, J.L. (author), de Groot, J. (author), Bank, R.A. (author), Gaubius Instituut TNO (author)
Doxycycline (DOX) profoundly inhibited collagen synthesis by differentiated articular chondrocytes. At 25 microM, the rate of collagen synthesis was suppressed by more than 50% without affecting cell proliferation (DNA levels) and general protein synthesis (35S-Met and 35S-Cys incorporation). Steady-state mRNA levels of type II collagen were...
article 1998
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Beekman, B. (author), Verzijl, N. (author), de Roos, J.A.D.M. (author), TeKoppele, J.M. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Objective: To determine the role of interleukin-1β (IL-1β) in the degradation of proteoglycans and collagen by articular chondrocytes. Design: Chondrocytes were cultured in alginate beads for 2 weeks to produce extracellular matrix, followed by the addition of IL-1β for 1 or 2 days. Breakdown of extracellular matrix (with and without activation...
article 1998
document
TNO Preventie en Gezondheid (author), Beekman, B. (author)
doctoral thesis 1998
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