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Lamers, R.-J.A.N. (author), de Groot, J. (author), Spies-Faber, E.J. (author), Jellema, R.H. (author), Kraus, V.B. (author), Verzijl, N. (author), te Koppele, J.M. (author), Spijksma, G.K. (author), Vogels, J.T.W.E. (author), van der Greef, J. (author), van Nesselrooij, J.H.J. (author)
Osteoarthritis (OA), one of the most common diseases among the elderly, is characterized by the progressive destruction of joint tissues. Its etiology is largely unclear and no effective disease-modifying treatment is currently available. Metabolic fingerprinting provides a novel tool for the identification of biomarkers. A metabolic fingerprint...
article 2003
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Hosli, E. (author), Detmar, S. (author), Raat, H. (author), Bruil, J. (author), Vogels, T. (author), Verrips, E. (author), TNO Kwaliteit van Leven (author)
The Child Health Questionnaire (CHQ)-87-item child and adolescent self-report (CF87) is an increasingly used health-related quality-of-life instrument for measuring the self-perceived physical and psychosocial well-being of children aged 10 years and older. The aims of this study were to evaluate structure, reliability and validity of the Dutch...
article 2007
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Clish, C.B. (author), Davidov, E. (author), Oresic, M. (author), Plasterer, T.N. (author), Lavine, G. (author), Londo, T. (author), Meys, M. (author), Snell, P. (author), Stochaj, W. (author), Adourian, A. (author), Zhang, X. (author), Morel, N. (author), Neumann, E. (author), Verheij, E. (author), Vogels, J.T.W.E. (author), Havekes, L.M. (author), Afeyan, N. (author), Regnier, F. (author), van der Greef, J. (author), Naylor, S. (author), TNO Preventie en Gezondheid (author)
Integrative (or systems biology) is a new approach to analyzing biological entities as integrated systems of genetic, genomic, protein, metabolite, cellular, and pathway events that are in flux and interdependent. Here, we demonstrate the application of intregrative biological analysis to a mammalian disease model, the apolipoprotein E3-Leiden ...
article 2004
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Fekkes, M. (author), Pijpers, F.I.M. (author), Fredriks, A.M. (author), Vogels, T. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)
OBJECTIVES. A number of studies have shown that victimization from bullying behavior is associated with substantial adverse effects on physical and psychological health, but it is unclear which comes first, the victimization or the health-related symptoms. In our present study, we investigated whether victimization precedes psychosomatic and...
article 2006
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Kater, A.P. (author), Heijboer, H. (author), Peters, M. (author), Vogels, T. (author), Prins, M.H. (author), Heymans, H.S.A. (author)
Objective. To determine the differences in quality of life between children with sickle cell disease and healthy immigrant children. Design. Descriptive, comparative. Method. The quality of life of children with sickle cell disease between 5 and 15 years old being treated in the Emma Children's Hospital AMC in Amsterdam, the Netherlands, was...
article 1999
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Theunissen, N.C.M. (author), Vogels, T.G.C. (author), Koopman, H.M. (author), Verrips, G.H.W. (author), Zwinderman, K.A.H. (author), Verloove-Vanhorick, S.P. (author), Wit, J.M. (author), TNO Preventie en Gezondheid (author)
This study evaluates the agreement between child and parent reports on children's health-related quality of life (HRQoL) in a representative sample of 1,105 Dutch children (age 8-11 years old). Both children and their parents completed a 56 item questionnaire (TACQOL). The questionnaire contains seven eight-item scales: physical complaints,...
article 1998
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Bouwman, J. (author), Vogels, J.T.W.E. (author), Wopereis, S. (author), Rubingh, C.M. (author), Bijlsma, S. (author), van Ommen, B. (author)
Background: Being able to visualize multivariate biological treatment effects can be insightful. However the axes in visualizations are often solely defined by variation and thus have no biological meaning. This makes the effects of treatment difficult to interpret. Methods: A statistical visualization method is presented, which analyses and...
article 2012
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van der Wielen, N. (author), van Avesaat, M. (author), de Wit, N.J.W. (author), Vogels, J.T.W.E. (author), Troost, F. (author), Masclee, A. (author), Koopmans, S.J. (author), van der Meulen, J. (author), Boekschoten, M.V. (author), Muller, M. (author), Hendriks, Henk F.J. (author), Witkamp, Renger F. (author), Meijerink, Jocelijn (author)
Introduction: Intestinal chemosensory receptors and transporters are able to detect food-derived molecules and are involved in the modulation of gut hormone release. Gut hormones play an important role in the regulation of food intake and the control of gastrointestinal functioning. This mechanism is often referred to as ‘‘nutrient sensing’’....
article 2014
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Rompelberg, C.J.M. (author), Vogels, J.T.W.E. (author), de Vogel, N. (author), Bruijntjes-Rozier, G.C.D.M. (author), Stenhuis, W.H. (author), Bogaards, J.J.P. (author), Verhagen, H. (author), TNO Voeding (author)
1. In order to study the antigenotoxic potential of eugenol in humans, ten healthy non-smoking males ingested a daily amount of 150 mg eugenol or the placebo for seven consecutive days. After a washout period of one week, groups ingesting eugenol or the placebo were crossed and received the other treatment for seven consecutive days. 2. On days...
article 1996
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de Wolff, M.S. (author), Vogels, A.G.C. (author), Reijneveld, S.A. (author)
The DSM-oriented approach of the Child Behavior Checklist (CBCL) is a relatively new classification of problem behavior in children and adolescents. Given the clinical and scientific relevance of the CBCL, this study examines similarities and dissimilarities between the empirical and the DSM-oriented approach of the CBCL.We used data from 7,852...
article 2014
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Hille, E.T.M. (author), den Ouden, A.L. (author), Stuifbergen, M.C. (author), Verrips, G.H.W. (author), Vogels, A.G.C. (author), Brand, R. (author), Gravenhorst, J.B. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)
Aim: To assess whether attrition rate influences outcome in the follow-up of very preterm infants. Study design: In a national follow-up study of infants born alive in 1983 in the Netherlands with a gestational age less than 32 weeks and/or a birth weight less than 1500 g, outcome was assessed separately for adolescents who responded early or...
article 2005
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Leeman, W.R. (author), Rouhani-Rankouhi, T. (author), Vogels, J. (author), Krul, L. (author)
Recently, the European Food Safety Authority (EFSA) stated that the Threshold of Toxicological Concern
article 2016
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Theunissen, M.H.C. (author), de Wolff, M.S. (author), Vogels, A.G.C. (author), Reijneveld, S.A. (author)
Op 17 juni 2013 promoveerde Meinou Theunissen op het proefschrift ‘The early detection of psychosocial problems in children aged 0 to 6 years by Dutch preventive child Healthcare: professionals and their tools’. Het proefschrift richt zich op de vroegsignalering door de jeugdgezondheidszorg van emotionele en gedragsproblemen (psychosociale...
article 2014
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Kamphuis, M. (author), Vliegen, H.W. (author), Vogels, T. (author), Zwinderman, K.H. (author), van der Wall, E.E. (author), Verloove-Vanhorick, S.P. (author), Ottenkamp, J. (author), TNO Preventie en Gezondheid (author)
Objective: To discuss the need for continuing cardiac surveillance in adults with hemodynamically insignificant congenital cardiac disease. Methods: In 82 patients with mild congenital cardiac malformations, aged from 17 to 32 years, we investigated the subjective health status, the health-related quality of life, any difficulties encountered in...
article 2002
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Teunissen, M.J. (author), op den Camp, H.J.M. (author), Orpin, C.G. (author), Huis in 't Veld, J.H.J. (author), Vogels, G.D. (author)
article 1991
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Wiefferink, C.H. (author), Detmar, S.B. (author), Coumans, B. (author), Vogels, T. (author), Paulussen, T.G.W. (author), TNO Kwaliteit van Leven (author)
The aim of this study is to identify the social psychological determinants of the use of performance-enhancing drugs by gym users who practice bodybuilding, fitness, powerlifting or combat sports. In this questionnaire-based study, 144 respondents answered questions on their actual use and intention to use such drugs and also on their background...
article 2008
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Theunissen, M.H.C. (author), Vogels, A.G.C. (author), Reijneveld, S.A. (author)
OBJECTIVE: In this study we examined the use and predictors of different discipline practices by parents of children aged 5 to 6 years. METHODS: We obtained cross-sectional data for a nationally representative Dutch sample of children aged 5 to 6 years within the setting of routine well-child visits provided to the entire population. A total of...
article 2015
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Vogels, J.T.W.E. (author), Terwel, L. (author), Tas, A.C. (author), van den Berg, F. (author), Dukel, F. (author), van der Greef, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
This paper describes the application of proton NMR spectroscopy as a screening tool for the determination of the authenticity of orange juices. Principal component and discriminant analyses were used to discriminate between authentic and nonauthentic (suspect) samples. In one set of profiles, additions of sucrose, beet medium invert sugar,...
article 1996
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van Doorn, M. (author), Vogels, J. (author), Tas, A. (author), van Hoogdalem, E.J. (author), Burggraaf, J. (author), Cohen, A. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
Aims: To explore the usefulness of metabolomics as a method to obtain a broad array of biomarkers for the pharmacological effects of rosiglitazone (RSG) in plasma and urine samples from patients with type 2 diabetes mellitus (T2DM) and healthy volunteers (HVs). Additionally, we explored the differences in metabolite concentrations between T2DM...
article 2007
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Vogels, T. (author), Theunissen, N.C.M. (author), Verrips, G.H.W. (author), Koopman, H.M. (author), Verloove-Vanhorick, S.P. (author), Kamphuis, R.P. (author), TNO Preventie en Gezondheid (author)
De WHO definieert gezondheid als 'a state of comple­te physical, mental and social well-being, and not merely the absence of disease or infirmity'. De defini­tie stamt uit 1947 en wordt in principe door vrijwel iedereen met instemming aangehaald. Wanneer je echter kijkt naar de manier waarop gezondheid in onderzoek wordt vastgesteld en...
article 1996
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