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Perini, F. (author), Powell, T. (author), Watt, S.J. (author), Downing, P.E. (author)
The brain must interpret sensory input from diverse receptor systems to estimate object properties. Much has been learned about the brain mechanisms behind these processes in vision, but our understanding of haptic perception remains less clear. Here we examined haptic judgments of object size, which require integrating multiple cutaneous and...
article 2020
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Moné, M.J. (author), Pallocca, G. (author), Escher, S.E. (author), Exner, T. (author), Herzler, M. (author), Hougaard Bennekou, S. (author), Kamp, H. (author), Kroese, E.D. (author), Leist, M. (author), Steger-Hartmann, T. (author), van de Water, B. (author)
In 2016, the European Commission launched the EU-ToxRisk research project to develop and promote animal-free approaches in toxicology. The 36 partners of this consortium used in vitro and in silico methods in the context of case studies (CSs). These CSs included both compounds with a highly defined target (e.g. mitochondrial respiratory chain...
article 2020
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Abe, N. (author), Kato, S. (author), Tsuchida, T. (author), Sugimoto, K. (author), Saito, R. (author), Verschuren, L. (author), Kleemann, R. (author), Oka, K. (author)
Non-alcoholic steatohepatitis (NASH) is a fast-growing liver disease in the Western world. Currently, only a few animal models show both the metabolic and histological features of human NASH. We aimed to explore murine NASH models in a time dependent manner that exhibit metabolic, histological and transcriptomic hallmarks of human NASH. For this...
article 2019
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Ly, V. (author), Roijendijk, L.L.M. (author), Hazebroek, H. (author), Tonnaer, C. (author), Hagenaars, M.A. (author)
Freezing is a defensive response to acute stress that is associated with coping and alterations in attentional processing. However, it remains unclear whether individuals in high risk professions, who are skilled at making rapid decisions in emergency situations, show altered threat-induced freezing. Here we investigated the effect of incident...
article 2017
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van Kampen, J. (author), van der Beek, D. (author), Steijn, W. (author), Groeneweg, J. (author), Guldenmund, F. (author)
Background. Organisations spend a considerable amount of time and effort on diagnosing and analysing risks within their organisation. In the area of occupational and process safety, a myriad of employee survey instruments is available. Many studies show that operational processes play an important role in an organisations overall safety. Yet, so...
article 2017
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van Ombergen, A. (author), Lubeck, A.J. (author), van Rompaey, V. (author), Maes, L.K. (author), Stins, J.F. (author), van de Heyning, P.H. (author), Wuyts, F.L. (author), Bos, J.E. (author)
Background: Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visual vestibular mismatch (VVM). These patients therefore experience discomfort, disorientation, dizziness and postural unsteadiness. Objective: Firstly, we aimed to get a better insight in the underlying mechanism...
article 2016
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Prins, R.G. (author), Pierik, F. (author), Etman, A. (author), Sterkenburg, R.P. (author), Kamphuis, C.B.M. (author), van Lenthe, F.J. (author)
In choosing appropriate buffer sizes to study environmental influences on physical activity, studies are hampered by insufficient insight into the distance elderly travel actively. This study aims at getting insight into the number of trips walked and cycled within various buffer sizes using GPS measures. Data were obtained from the Elderly And...
article 2014
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Risto, M. (author), Martens, M.H. (author)
With specific headway instructions drivers are not able to attain the exact headways as instructed. In this study, the effects of discrete headway feedback (and the direction of headway adjustment) on headway accuracy for drivers carrying out time headway instructions were assessed experimentally. Two groups of each 10 participants (one...
article 2014
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Zimmer, B. (author), Pallocca, G. (author), Dreser, N. (author), Foerster, S. (author), Waldmann, T. (author), Westerhout, J. (author), Julien, S. (author), Krause, K.H. (author), Van Thriel, C. (author), Hengstler, J.G. (author), Sachinidis, A. (author), Bosgra, S. (author), Leist, M. (author)
Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based on a limited number of toxicants. Within the embryonic stem cell-based novel alternative tests project, we developed a test battery framework that allows inclusion of any developmental toxicity assay and that explores the responses of such test...
article 2014
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Geraedts, A.S. (author), Kleiboer, A.M. (author), Wiezer, N.M. (author), van Mechelen, W. (author), Cuijpers, P. (author)
Background: Depressive disorders are highly prevalent in the working population and are associated with excessive costs for both society and companies. Effective treatment for employees with depressive symptoms in occupational health care is limited. The purpose of this study is to investigate the effectiveness and cost-effectiveness of an...
article 2013
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Dambacher, W.M. (author), de Kort, E.H.M. (author), Blom, W.M. (author), Houben, G.F. (author), de Vries, E. (author)
Background: Children with cow's milk allergy (CMA) need a cow's milk protein (CMP) free diet to prevent allergic reactions. For this, reliable allergy-information on the label of food products is essential to avoid products containing the allergen. On the other hand, both overzealous labeling and misdiagnosis that result in unnecessary...
article 2013
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Wagenaar, A.F. (author), Kompier, M.A.J. (author), Houtman, I.L.D. (author), van den Bossche, S.N.J. (author), Taris, T.W. (author)
OBJECTIVE:: The healthy worker effect implies that healthy workers go "up" in employment status whereas less healthy workers go "down" into precarious temporary employment or unemployment. These hypotheses were tested during an economic recession, by predicting various upward and downward contract trajectories, based on workers' health status,...
article 2012
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Jacobs, J.H. (author), Fuertes, E. (author), Krop, E.J.M. (author), Spithoven, J. (author), Tromp, P. (author), Heederik, D.J.J. (author)
Objectives: To describe associations among swimming, respiratory health, allergen sensitisation and Clara cell protein 16 (CC16) levels in Dutch schoolchildren. Trichloramine levels in swimming pool air were determined to assess potential exposure levels. Methods: Respiratory health and pool attendance information was collected from 2359...
article 2012
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de Korte, E.M. (author), Huysmans, M.A. (author), de Jong, A.M. (author), van de Ven, J.G.M. (author), Ruijsendaal, M. (author)
This study investigated the effects of non-obtrusive feedback on continuous lifted hand/finger behaviour, task performance and comfort. In an experiment with 24 participants the effects of two visual and two tactile feedback signals were compared to a no-feedback condition in a computer task. Results from the objective measures showed that all...
article 2012
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Ellegast, R.P. (author), Kraft, K. (author), Groenesteijn, L. (author), Krause, F. (author), Berger, H. (author), Vink, P. (author)
Prolonged and static sitting postures provoke physical inactivity at VDU workplaces and are therefore discussed as risk factors for the musculoskeletal system. Manufacturers have designed specific dynamic office chairs featuring structural elements which promote dynamic sitting and therefore physical activity. The aim of the present study was to...
article 2012
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Stomp-van den Berg, G.M. (author), Hendriksen, I.J.M. (author), Bruinvels, D.J. (author), Twisk, J.W.R. (author), van Mechelen, W. (author), van Poppel, M.N.M. (author)
The objective of this study was to examine which factors during pregnancy and postpartum predict pelvic girdle pain (PGP) at 12 weeks postpartum among working women. A total of 548 Dutch pregnant employees were recruited in 15 companies, mainly health care, child care, and supermarkets. The definition of PGP was any pain felt in the pelvic...
article 2012
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Janssens, A.C.J.W. (author), Henneman, L. (author), Detmar, S.B. (author), Khoury, M.J. (author), Steyerberg, E.W. (author), Eijkemans, M.J.C. (author), Mushkudiani, N. (author), Oostra, B.A. (author), van Duijn, C.M. (author), MacKenbach, J.P. (author)
Objective: We investigated the accuracy of self-reported family history for diabetes, hypertension, and overweight against two reference standards: family history based on physician-assessed health status of relatives and on self-reported personal health status of relatives. Study Design and Setting: Subjects were participants from the Erasmus...
article 2012
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Engelen, V. (author), Detmar, S. (author), Koopman, H. (author), Maurice-Stam, H. (author), Caron, H. (author), Hoogerbrugge, P. (author), Egeler, R.M. (author), Kaspers, G. (author), Grootenhuis, M. (author)
Background: The aim of the current study is to investigate the effectiveness of an intervention that provides health-related quality of life (HRQOL) scores of the patient (the QLIC-ON PROfile) to the pediatric oncologist. Procedure: Children with cancer participated in a sequential cohort intervention study: intervention N=94, control N=99....
article 2012
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Liebrechts-Akkerman, G. (author), Lao, O. (author), Liu, F. (author), van Sleuwen, B.E. (author), Engelberts, A.C. (author), L'Hoir, M.P. (author), Tiemeier, H.W. (author), Kayser, M. (author)
Background: Sudden infant death syndrome (SIDS) is the unexpected death of an infant that remains unexplained after a thorough investigation of the circumstances, family history, paediatric investigation and complete autopsy. In Western society, it is the leading cause of post-neonatal death below 1 year of age. In the Netherlands, the SIDS...
article 2011
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Driessen, M.T. (author), Proper, K.I. (author), Anema, J.R. (author), Knol, D.L. (author), Bongers, P.M. (author), van der Beek, A.J. (author)
Objectives: This study investigated the effectiveness of the Stay@Work participatory ergonomics programme to reduce workers9 exposure to psychosocial and physical risk factors. Methods: 37 departments (n=3047 workers) from four Dutch companies participated in this cluster randomised controlled trial; 19 (n=1472 workers) were randomised to an...
article 2011
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