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Perini, F. (author), Powell, T. (author), Watt, S.J. (author), Downing, P.E. (author)
The brain must interpret sensory input from diverse receptor systems to estimate object properties. Much has been learned about the brain mechanisms behind these processes in vision, but our understanding of haptic perception remains less clear. Here we examined haptic judgments of object size, which require integrating multiple cutaneous and...
article 2020
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Dong, D. (author), Espinoza, L.A.T. (author), Loibl, A. (author), Pfaff, M. (author), Tukker, A. (author), van der Voet, E. (author)
article 2020
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Moné, M.J. (author), Pallocca, G. (author), Escher, S.E. (author), Exner, T. (author), Herzler, M. (author), Hougaard Bennekou, S. (author), Kamp, H. (author), Kroese, E.D. (author), Leist, M. (author), Steger-Hartmann, T. (author), van de Water, B. (author)
In 2016, the European Commission launched the EU-ToxRisk research project to develop and promote animal-free approaches in toxicology. The 36 partners of this consortium used in vitro and in silico methods in the context of case studies (CSs). These CSs included both compounds with a highly defined target (e.g. mitochondrial respiratory chain...
article 2020
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Krone, T. (author), Boessen, R. (author), Bijlsma, S. (author), van Stokkum, R. (author), Clabbers, N.D.S. (author), Pasman, W.J. (author)
Background. N-of-1 designs gain popularity in nutritional research because of the improving technological possibilities, practical applicability and promise of increased accuracy and sensitivity, especially in the field of personalized nutrition. This move asks for a search of applicable statistical methods. Objective. To demonstrate the...
article 2020
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Ly, V. (author), Roijendijk, L.L.M. (author), Hazebroek, H. (author), Tonnaer, C. (author), Hagenaars, M.A. (author)
Freezing is a defensive response to acute stress that is associated with coping and alterations in attentional processing. However, it remains unclear whether individuals in high risk professions, who are skilled at making rapid decisions in emergency situations, show altered threat-induced freezing. Here we investigated the effect of incident...
article 2017
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van Kampen, J. (author), van der Beek, D. (author), Steijn, W. (author), Groeneweg, J. (author), Guldenmund, F. (author)
Background. Organisations spend a considerable amount of time and effort on diagnosing and analysing risks within their organisation. In the area of occupational and process safety, a myriad of employee survey instruments is available. Many studies show that operational processes play an important role in an organisations overall safety. Yet, so...
article 2017
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van Ombergen, A. (author), Lubeck, A.J. (author), van Rompaey, V. (author), Maes, L.K. (author), Stins, J.F. (author), van de Heyning, P.H. (author), Wuyts, F.L. (author), Bos, J.E. (author)
Background: Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visual vestibular mismatch (VVM). These patients therefore experience discomfort, disorientation, dizziness and postural unsteadiness. Objective: Firstly, we aimed to get a better insight in the underlying mechanism...
article 2016
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van der Heijden, R.A. (author), Morrison, M.C. (author), Sheedfar, F. (author), Mulder, P. (author), Schreurs, M. (author), Hommelberg, P.P.H. (author), Hofker, M.H. (author), Schalkwijk, C. (author), Kleemann, R. (author), Tietge, U.J.F. (author), Koonen, D.P.Y. (author), Heeringa, P. (author)
Background. Naturally occurring substances from the flavanol and anthocyanin family of polyphenols have been proposed to exert beneficial effects in the course of obesity. We hypothesized that their effects on attenuating obesity-induced dyslipidemia as well as the associated inflammatory sequelae especially have health-promoting potential....
article 2016
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Ettwig, J.F. (author), Bronkhorst, A.W. (author)
In four experiments, we studied the time course of interference between detection of an oddball orientation target (OT) in an 8-item circular search display, and identification of a letter target (LT) in a central stream of distractor letters. Dual-task performance for different temporal lags between targets was compared to single-task...
article 2015
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Teunis, M.A.T. (author), Spiekstra, S.W. (author), Smits, M. (author), Adriaens, E. (author), Eltze, T. (author), Galbiati, V. (author), Krul, C.A.M. (author), Landsiedel, R. (author), Pieters, R. (author), Reinders, J. (author), Roggen, E. (author), Corsini, E. (author), Gibbs, S. (author)
This study describes the international ring trial of the epidermal-equivalent (EE) sensitizer potency assay. This assay does not distinguish a sensitizer from a non-sensitizer, but may classify known skin sensitizers according to their potency. It assesses the chemical concentration resulting in 50% cytotoxicity (EE-EC50) or the 2-fold increase...
article 2014
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Minguillón, M.C. (author), Cirach, M. (author), Hoek, G. (author), Brunekreef, B. (author), Tsai, M. (author), de Hoogh, K. (author), Jedynska, A. (author), Kooter, I.M. (author), Nieuwenhuijsen, M. (author), Querol, X. (author)
Trace and major elements concentrations in PM10 and PM2.5 were measured at 20 sites spread in the Barcelona metropolitan area (1 rural background, 6 urban background, 13 road traffic sites) and at 1 reference site. Three 2-week samples per site and size fraction were collected during 2009 using low volume samplers, adding a total of 120 samples....
article 2014
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Schreuder, E. (author), Hoeksma, M.R. (author), Smeets, M.A.M. (author), Semin, G.R. (author)
This study reports an examination of the internal clock model, according to which subjective time duration is influenced by attention and arousal state. In a time production task, we examine the hypothesis that an arousing odor and an upright body posture affect perceived duration. The experimental task was performed while participants were...
article 2014
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Prins, R.G. (author), Pierik, F. (author), Etman, A. (author), Sterkenburg, R.P. (author), Kamphuis, C.B.M. (author), van Lenthe, F.J. (author)
In choosing appropriate buffer sizes to study environmental influences on physical activity, studies are hampered by insufficient insight into the distance elderly travel actively. This study aims at getting insight into the number of trips walked and cycled within various buffer sizes using GPS measures. Data were obtained from the Elderly And...
article 2014
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Risto, M. (author), Martens, M.H. (author)
With specific headway instructions drivers are not able to attain the exact headways as instructed. In this study, the effects of discrete headway feedback (and the direction of headway adjustment) on headway accuracy for drivers carrying out time headway instructions were assessed experimentally. Two groups of each 10 participants (one...
article 2014
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Levels, K. (author), de Koning, J.J. (author), Mol, E. (author), Foster, C. (author), Daanen, H.A.M. (author)
This study examined the effect of active pre-warming on speed and quality of performance during simulated firefighting exercise. Twelve male firefighters performed two trials in counterbalanced order. They were either pre-warmed by 20-min cycling at 1.5 Watt kg-1 body mass (WARM) or remained thermoneutral (CON) prior to a simulated firefighting...
article 2014
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Pieters, S. (author), Burk, W.J. (author), Vorst, H.V.D. (author), Engels, R.C. (author), Wiers, R.W. (author)
Background: Dual process models suggest that the development of addictive behaviors is the result of interplay between impulsive and reflective processes, modulated by boundary conditions such as individual or situational factors. Empirical support for this model has been repeatedly demonstrated in adult samples [for a meta-analysis, see Ref. (1...
article 2014
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Zimmer, B. (author), Pallocca, G. (author), Dreser, N. (author), Foerster, S. (author), Waldmann, T. (author), Westerhout, J. (author), Julien, S. (author), Krause, K.H. (author), Van Thriel, C. (author), Hengstler, J.G. (author), Sachinidis, A. (author), Bosgra, S. (author), Leist, M. (author)
Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based on a limited number of toxicants. Within the embryonic stem cell-based novel alternative tests project, we developed a test battery framework that allows inclusion of any developmental toxicity assay and that explores the responses of such test...
article 2014
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Geraedts, A.S. (author), Kleiboer, A.M. (author), Wiezer, N.M. (author), van Mechelen, W. (author), Cuijpers, P. (author)
Background: Depressive disorders are highly prevalent in the working population and are associated with excessive costs for both society and companies. Effective treatment for employees with depressive symptoms in occupational health care is limited. The purpose of this study is to investigate the effectiveness and cost-effectiveness of an...
article 2013
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Dambacher, W.M. (author), de Kort, E.H.M. (author), Blom, W.M. (author), Houben, G.F. (author), de Vries, E. (author)
Background: Children with cow's milk allergy (CMA) need a cow's milk protein (CMP) free diet to prevent allergic reactions. For this, reliable allergy-information on the label of food products is essential to avoid products containing the allergen. On the other hand, both overzealous labeling and misdiagnosis that result in unnecessary...
article 2013
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Mutlu, E. (author), Warren, S.H. (author), Matthews, P.P. (author), King, C. (author), Linak, W.P. (author), Kooter, I.M. (author), Schmid, J.E. (author), Ross, J.A. (author), Ian Gilmour, M. (author), DeMarini, D.M. (author)
Several types of diesel exhaust particles (DEPs) have been used for toxicology studies, including a highorganic automobile DEP (A-DEP) from Japan, and a low-organic forklift DEP developed by the National Institute of Standards and Technology (N-DEP). However, these DEPs were not characterized extensively for chemical composition or sub...
article 2013
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