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document
Bobeldijk, I. (author), Hekman, M. (author), van der Vries de- Weij, J. (author), Coulier, L. (author), Ramaker, R. (author), Kleemann, R. (author), Kooistra, T. (author), Rubingh, C. (author), Freidig, A. (author), Verheij, E. (author), TNO Kwaliteit van Leven (author)
We report a sensitive, generic method for quantitative profiling of bile acids and other endogenous metabolites in small quantities of various biological fluids and tissues. The method is based on a straightforward sample preparation, separation by reversed-phase high performance liquid-chromatography mass spectrometry (HPLC-MS) and electrospray...
article 2008
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Hu, C. (author), van Dommelen, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T.H. (author), Wang, M. (author), Slee, E. (author), Lu, X. (author), Xu, G. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
A reversed-phase liquid chromatography-linear ion trap-Fourier transform ion cyclotron resonance-mass spectrometry method was developed for the profiling of lipids in human and mouse plasma. With the use of a fused-core C<sub>8</sub> column and a binary gradient, more than 160 lipids belonging to eight different classes were detected in a single...
article 2008
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Tomaso, H. (author), Jacobs, D. (author), Eickhoff, M. (author), Scholz, H.C. (author), al Dahouk, S. (author), Kattar, M.M. (author), Reischl, U. (author), Plicka, H. (author), Strand Olsen, J. (author), Nikkari, S. (author), Matero, P. (author), Beuret, C. (author), Ciammaruconi, A. (author), Lista, F. (author), Gala, J.-L. (author), Broll, H. (author), Appel, B. (author), Sellek Cano, R.E. (author), Ybarra de Villavicencio, M.D.C. (author), Broekhuijsen, M.P. (author), Indra, A. (author), Petersen, R. (author), Neubauer, H. (author)
Background: Yersinia pestis (Y. pestis) is a zoonotic bacterium mainly circulating among rodents and their fleas. Transmission to humans can cause bubonic, pneumonic or septicemic plague with a high case-fatality rate. Therefore, rapid and reliable diagnostic tools are crucial. The objective of this study was to assess the inter-laboratory...
article 2008
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Robitail, S. (author), Ravens-Sieberer, U. (author), Simeoni, M.C. (author), Rajmil, L. (author), Bruil, J. (author), Power, M. (author), Duer, W. (author), Cloetta, B. (author), Czemy, L. (author), Mazur, J. (author), Czimbalmos, A. (author), Tountas, Y. (author), Hagquist, C. (author), Kilroe, J. (author), Auquier, P. (author), Fuerth, K. (author), Czerny, L. (author), Erhart, M. (author), Nickel, J. (author), Kurth, B.-M. (author), Gosch, A. (author), Von Rüden, U. (author), Dimitrakakis, C. (author), Aszman, A. (author), Flannery, E. (author), Detmar, S. (author), Veripps, E. (author), Mierzejeswka, E. (author), Berra, S. (author), Tebé, C. (author), Herdman, M. (author), Alonso, J. (author), Abel, T. (author), Bisegger, C. (author), Farley, C. (author), Atherton, C. (author), Phillips, K. (author), TNO Kwaliteit van Leven (author)
Objectives: The aim of this study is to assess the structural and cross-cultural validity of the KIDSCREEN-27 questionnaire. Methods: The 27-item version of the KIDSCREEN instrument was derived from a longer 52-item version and was administered to young people aged 8-18 years in 13 European countries in a cross-sectional survey. Structural and...
article 2007
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van Oyen, H. (author), Heyden, J. (author), Perenboom, R. (author), Jagger, C. (author), TNO Preventie en Gezondheid (author)
Objective: To evaluate a single item instrument, the Global Activity Limitation Indicator (GALI), to measure long-standing health related activity limitations, against several health indicators: a composite morbidity indicator, instruments measuring mental health (SCL-90R, GHQ-12), physical co-morbidity and physical limitations (ADLs, SF-36)....
article 2006
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Detmar, S.B. (author), Hosli, E.J. (author), Chorus, A.M.J. (author), van Beekum, T. (author), Vogels, T. (author), Mourad-Baars, P.E.C. (author), Engelberts, A.C. (author), Groothuis - Oudshoorn, C.G.M. (author), Verrips, G.H.W. (author)
Introduction: This paper describes the development and initial psychometric evaluation of the Handicap Scale for Children (HSC). This questionnaire is based on the London Handicap Scale (LHS), a valid and reliable utility instrument for measuring social participation in adults. Methods: A multidisciplinary research group was involved in...
article 2005
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Heinrich, J. (author), Blatter, B.M. (author), Bongers, P.M. (author)
Aim: To compare two different methods for assessment of postural load and duration of computer use in office workers. Methods: The study population existed of 87 computer workers. Questionnaire data about exposure were compared with exposures measured by a standardised or objective method. Measuring true exposure to postural load consisted of an...
article 2004
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Paneth, N. (author), Qiu, H. (author), Rosenbaum, P. (author), Saigal, S. (author), Bishai, S. (author), Jetton, J. (author), den Ouden, L. (author), Broyles, S. (author), Tyson, J. (author), Kugler, K. (author)
The reliability of classification of cerebral palsy (CP) in low-birthweight children was assessed by using clinical and research study records sampled from population-based cohort studies in the USA, the Netherlands, Canada, and Germany. Records of neurological examination findings and functional motor assessments were submitted to up to five...
article 2003
document
Bueters, T.J.H. (author), van Helden, H.P.M. (author), IJzerman, A.P. (author), Danhof, M. (author)
The objective of this study was to characterize the effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) and its low efficacy derivatives 2′-deoxy-CPA (2DCPA), 3′-deoxy-CPA (3DCPA), 8-ethylamino-CPA (8ECPA) and 8-butylamino-CPA (8BCPA) on the release of acetylcholine (ACh) using intrastriatal microdialysis. These low...
article 2003
document
de Kleine, M.J.K. (author), den Ouden, A.L. (author), Kollée, L.A.A. (author), van der Nijhuis - Sanden, M.W.G. (author), Sondaar, M. (author), Kessel van - Feddema, B.J.M. (author), Knuijt, S. (author), van Baar, A.L. (author), Ilsen, A. (author), Breur-Pieterse, R. (author), Briët, J.M. (author), Brand, R. (author), Verloove-Vanhorick, S.P. (author)
Background: Long term follow up shows a high frequency of developmental disturbances in preterm survivors of neonatal intensive care formerly considered non-disabled. Aims: To develop and validate an assessment tool that can help paediatricians to identify before 6 years of age which survivors have developmental disturbances that may interfere...
article 2003
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van der Heijden, P.G.M. (author), van Buuren, S. (author), Fekkes, M. (author), Radder, J. (author), Verrips, E. (author)
The sub-scales of the SF-36 in the Dutch National Study are investigated with respect to unidimensionality and reliability. It is argued that these properties deserve separate treatment. For unidimensionality we use a non-parametric model from item response theory, called the Mokken scaling model, and compute the corresponding scalability...
article 2003
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Reijneveld, S.A. (author), Stronks, K. (author)
Background. Socioeconomic differences in health and in use of health care are well known. Most data on socioeconomic differences in health care utilization are based on retrospective self-report in community surveys, but the evidence on the validity of self-reported utilization of health care across socioeconomic groups is limited. The aim of...
article 2001
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Hildebrandt, V.H. (author), Bongers, P.M. (author), van Dijk, F.J. (author), Kempers, H.C.G. (author), Dul, J. (author)
The article describes the Dutch Musculoskeletal Questionnaire (DMQ) for the analysis of musculoskeletal workload and associated potential hazardous working conditions as well as musculoskeletal symptoms in worker populations. Its qualities are explored using a database of 1,575 workers in various occupations who completed the questionnaire. The...
article 2001
document
Hopman-Rock, M. (author), Tak, E.C.P.M. (author), Staats, P.G.M. (author), Jonker, C. (author), Wind, A.W. (author)
Aim of the study was the development and validation of a short observation list of possible early signs of dementia (OLD) for use in general practice. A stepwise development was carried out using reviews of publications and expert consensus. Experimental observations were carried out by 22 general practitioners in 19 Dutch practices. A field...
article 2001
document
Hopman-Rock, M. (author), Tak, E.C.P.M. (author), Staats, P.G.M. (author)
Objective: Development and validation of a short Observation List of possible early signs of Dementia (OLD) for use in general practice. Design: Stepwise development using reviews of publications and expert consensus. Field study for evaluation of reliability. Validation study (interviews, family forms) using existing valid and reliable measures...
article 2001
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Fekkes, M. (author), Theunissen, N.C.M. (author), Brugman, E. (author), Veen, S. (author), Verrips, E.G.H. (author), Koopman, H.M. (author), Vogels, T. (author), Wit, J.M. (author), Verloove-Vanhorick, S.P. (author)
The 43-item TNO-AZL Preschool Children Quality of Life (TAPQOL) questionnaire was developed to meet the need for a reliable and valid instrument for measuring parent's perceptions of health-related quality of life (HRQoL) in preschool children. HRQoL was defined as health status in 12 domains weighted by the impact of the health status problems...
article 2000
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TNO Biomedical Instrumentation (author), van Popele, N.M. (author), Bos, W.J.W. (author), de Beer, N.A.M. (author), van der Kuip, D.A.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Witteman, J.C.M. (author)
Oscillometric blood pressure devices tend to overestimate systolic blood pressure and underestimate diastolic blood pressure compared with sphygmomanometers. Recent studies indicate that discrepancies in performance between these devices may differ between healthy and diabetic subjects. Arterial stiffness in diabetics could be the underlying...
article 2000
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Aaronson, N.K. (author), Muller, M. (author), Cohen, P.D.A. (author), Essink-Bot, M.-L. (author), Fekkes, M. (author), Sanderman, R. (author), Sprangers, M.A.G. (author), te Velde, A. (author), Verrips, E. (author), TNO Preventie en Gezondheid (author)
The primary objectives of this research were to translate, validate, and generate normative data on the SF-36 Health Survey for use among Dutch- speaking residents of the Netherlands. Translation of the SF-36 into Dutch followed the stepwise, iterative procedures developed by the IQOLA Project. Following extensive pilot testing, the SF-36 was...
article 1998
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Schrauwen, Y. (author), Emeis, J.J. (author), Kooistra, T. (author), TNO Preventie en Gezondheid (author)
The development of a highly sensitive, enzyme-linked immunosorbent assay (ELISA) for tissue-type plasminogen activator (tPA) is described. The use of a biotin-avidin system resulted in a detection limit of 10 pg of tPA per ml, which is 50 to 150 times more sensitive than commercially-available ELISAs. Free tPA and tPA complexed to PA inhibitor...
article 1994
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Leenheers, L.H. (author), van Breugel, D.C. (author), Ravensberg, J.C. (author), Meuling, W.J.A. (author), Jongen, M.J.M. (author), Medisch Biologisch Laboratorium TNO (author)
An analytical method for the assessment of the exposure of workers to the pesticide propoxur through biological monitoring has been developed. This study was part of a survey of occupational exposure to pesticides used in greenhouses for the growing of ornamental plants. In order to assess the actual absorbed amount of propoxur in the body, an...
article 1992
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