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Wiefferink, C.H. (author), Detmar, S.B. (author), Coumans, B. (author), Vogels, T. (author), Paulussen, T.G.W. (author), TNO Kwaliteit van Leven (author)
The aim of this study is to identify the social psychological determinants of the use of performance-enhancing drugs by gym users who practice bodybuilding, fitness, powerlifting or combat sports. In this questionnaire-based study, 144 respondents answered questions on their actual use and intention to use such drugs and also on their background...
article 2008
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Kaptein, S. (author), Jansen, D.E.M.C. (author), Vogels, A.G.C. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)
Background: The assessment of mental health problems in children with intellectual disability (ID) mostly occurs by filling out long questionnaires that are not always validated for children without ID. The aim of this study is to assess the differences in mental health problems between children with ID and without ID, using a short...
article 2008
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Hosli, E. (author), Detmar, S. (author), Raat, H. (author), Bruil, J. (author), Vogels, T. (author), Verrips, E. (author), TNO Kwaliteit van Leven (author)
The Child Health Questionnaire (CHQ)-87-item child and adolescent self-report (CF87) is an increasingly used health-related quality-of-life instrument for measuring the self-perceived physical and psychosocial well-being of children aged 10 years and older. The aims of this study were to evaluate structure, reliability and validity of the Dutch...
article 2007
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van Doorn, M. (author), Vogels, J. (author), Tas, A. (author), van Hoogdalem, E.J. (author), Burggraaf, J. (author), Cohen, A. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
Aims: To explore the usefulness of metabolomics as a method to obtain a broad array of biomarkers for the pharmacological effects of rosiglitazone (RSG) in plasma and urine samples from patients with type 2 diabetes mellitus (T2DM) and healthy volunteers (HVs). Additionally, we explored the differences in metabolite concentrations between T2DM...
article 2007
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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.-P.H.T.M. (author), Smit, M.J. (author), Zandberg, P. (author), Horbach, G.J. (author), Mellema, J.-R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)
A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition is proposed for early detection of toxicity of investigational compounds in rats. The method is applied to detect toxicity upon administration of 13 toxic reference compounds and one nontoxic control compound (mianserine) in rats. The toxic compounds are...
article 2007
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Grootenhuis, M.A. (author), Koopman, H.M. (author), Verrips, G.H.W. (author), Vogels, A.G.C. (author), Last, B.F. (author), TNO Kwaliteit van Leven (author)
In paediatric research, Health-Related Quality-of-Life (HRQoL) has received increasing recognition as an important health outcome. This study aimed to investigate the nature and prevalence of HRQoL problems in children with different chronic diseases. Data were available on 318 children aged 8-11 years with different diseases: congenital heart...
article 2007
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Fekkes, M. (author), Pijpers, F.I.M. (author), Fredriks, A.M. (author), Vogels, T. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)
OBJECTIVES. A number of studies have shown that victimization from bullying behavior is associated with substantial adverse effects on physical and psychological health, but it is unclear which comes first, the victimization or the health-related symptoms. In our present study, we investigated whether victimization precedes psychosomatic and...
article 2006
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Hille, E.T.M. (author), den Ouden, A.L. (author), Stuifbergen, M.C. (author), Verrips, G.H.W. (author), Vogels, A.G.C. (author), Brand, R. (author), Gravenhorst, J.B. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)
Aim: To assess whether attrition rate influences outcome in the follow-up of very preterm infants. Study design: In a national follow-up study of infants born alive in 1983 in the Netherlands with a gestational age less than 32 weeks and/or a birth weight less than 1500 g, outcome was assessed separately for adolescents who responded early or...
article 2005
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Detmar, S.B. (author), Hosli, E.J. (author), Chorus, A.M.J. (author), van Beekum, T. (author), Vogels, T. (author), Mourad-Baars, P.E.C. (author), Engelberts, A.C. (author), Groothuis - Oudshoorn, C.G.M. (author), Verrips, G.H.W. (author)
Introduction: This paper describes the development and initial psychometric evaluation of the Handicap Scale for Children (HSC). This questionnaire is based on the London Handicap Scale (LHS), a valid and reliable utility instrument for measuring social participation in adults. Methods: A multidisciplinary research group was involved in...
article 2005
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Kamphuis, M. (author), Vliegen, H.W. (author), Verloove-Vanhorick, S.P. (author), Ottenkamp, J. (author), Vogels, T. (author)
Objective. To evaluate employment, career problems and job-related handicaps in adults with complex or mild congenital heart disease (CHD). Design. Cross-sectional. Method. Data were obtained from 76 patients with complex and 80 with mild CHD who were known to the Department of Paediatric Cardiology at the Leiden University Medical Center, the...
article 2005
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Orešič, M. (author), Clish, C.B. (author), Davidov, E.J. (author), Verheij, E. (author), Vogels, J. (author), Havekes, L.M. (author), Neumann, E. (author), Adourian, A. (author), Naylor, S. (author), van der Greef, J. (author), Plasterer, T. (author), TNO Preventie en Gezondheid (author)
Multifactorial diseases present a significant challenge for functional genomics. Owing to their multiple compartmental effects and complex biomolecular activities, such diseases cannot be adequately characterised by changes in single components, nor can pathophysiological changes be understood by observing gene transcripts alone. Instead, a...
article 2004
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Davidov, E. (author), Clish, C.B. (author), Oresic, M. (author), Meys, M. (author), Stochaj, W. (author), Snell, P. (author), Lavine, G. (author), Londo, T.R. (author), Adourian, A. (author), Zhang, X. (author), Johnston, M. (author), Morel, N. (author), Marple, E.W. (author), Plasterer, T.N. (author), Neumann, E. (author), Verheij, E. (author), Vogels, J.T.W.E. (author), Havekes, L.M. (author), van der Greef, J. (author), Naylor, S. (author), TNO Preventie en Gezondheid (author)
Multitiered quantitative analysis of biological systems is rapidly becoming the desired approach to study hierarchical functional interactions between proteins and metabolites. We describe here a novel systematic approach to analyze organisms with complex metabolic regulatory networks. By using precise analytical methods to measure biochemical...
article 2004
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Kamphuis, M. (author), Zwinderman, K.A.H. (author), Vogels, T. (author), Vliegen, H.W. (author), Kamphuis, R.P. (author), Ottenkamp, J. (author), Verloove-Vanhorick, S.P. (author), Bruil, J. (author), TNO Preventie en Gezondheid (author)
This study represents the development and validation of a cardiac-specific module of the generic health-related quality of life (HRQoL) instrument, the TAAQOL (TNO/AZL Adult Quality Of Life), for young adults with congenital heart disease (CHD). Items were selected based on literature, an explorative previous study in CHD patients, interviews...
article 2004
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Lamers, R.-J.A.N. (author), de Groot, J. (author), Spies-Faber, E.J. (author), Jellema, R.H. (author), Kraus, V.B. (author), Verzijl, N. (author), te Koppele, J.M. (author), Spijksma, G.K. (author), Vogels, J.T.W.E. (author), van der Greef, J. (author), van Nesselrooij, J.H.J. (author)
Osteoarthritis (OA), one of the most common diseases among the elderly, is characterized by the progressive destruction of joint tissues. Its etiology is largely unclear and no effective disease-modifying treatment is currently available. Metabolic fingerprinting provides a novel tool for the identification of biomarkers. A metabolic fingerprint...
article 2003
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Vogels, T. (author), Reijneveld, S.A. (author), Brugman, E. (author), den Hollander-Gijsman, M. (author), Verhulst, F.C. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author)
Background: An extended re-assessment of the psychometric properties of the LSPPK, an instrument aimed at identifying children with emotional and behavioural problems. Methods: Data came from a national sample in the Netherlands of parents of 1248 children (aged 5-6 years) interviewed by child health professionals (CHP). Data were obtained...
article 2003
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't Hart, B.A. (author), Vogels, J.T.W.E. (author), Spijksma, G. (author), Brok, H.P.M. (author), Polman, C. (author), van der Greef, J. (author), Primatencentrum TNO (author)
Proton nuclear magnetic resonance (1H-NMR) spectroscopy in combination with pattern recognition techniques were used to investigate the composition of organic compounds in urines from patients with multiple sclerosis (MS), patients with other neurological diseases (OND) and healthy controls (H). Using a valid animal model of MS, namely the...
article 2003
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Reijneveld, S.A. (author), Vogels, A.G.C. (author), Brugman, E. (author), van Ede, J. (author), Verhulst, F.C. (author), Verloove-Vanhorick, S.P. (author)
Background: Psychosocial problems, such as behavioural, emotional, and educational problems, are highly prevalent among children and adolescents. Early treatment may reduce these problems, if accurately identified. Validated questionnaires may support identification. The aim of this study is to assess the psychometric qualities of such a...
article 2003
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Kamphuis, M. (author), Vliegen, H.W. (author), Vogels, T. (author), Zwinderman, K.H. (author), van der Wall, E.E. (author), Verloove-Vanhorick, S.P. (author), Ottenkamp, J. (author), TNO Preventie en Gezondheid (author)
Objective: To discuss the need for continuing cardiac surveillance in adults with hemodynamically insignificant congenital cardiac disease. Methods: In 82 patients with mild congenital cardiac malformations, aged from 17 to 32 years, we investigated the subjective health status, the health-related quality of life, any difficulties encountered in...
article 2002
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Kamphuis, M. (author), Vogels, T. (author), Ottenkamp, J. (author), van der Wall, E.E. (author), Verloove-Vanhorick, S.P. (author), Vliegen, H.W. (author)
Objective: To evaluate job participation, careerrelated problems, and actual job problems in adults with complex congenital heart disease (CHD) compared with adults with mild CHD and reference groups. Design: Cross-sectional study. Setting: Patients were randomly selected from the archives of the Department of Pediatric Cardiology, Leiden...
article 2002
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Theunissen, N.C.M. (author), Kamp, G.A. (author), Koopman, H.M. (author), Zwinderman, K.A.H. (author), Vogels, T. (author), Wit, J.-M. (author), TNO Preventie en Gezondheid (author)
Objective: Changes in health-related quality of life (HRQOL) and self-esteem were studied in children with idiopathic short stature (ISS) participating in a study on the effect of growth hormone treatment. Study design: Prepubertal children (n = 36) with ISS were randomly assigned to a treatment or control group. Children with ISS, their parents...
article 2002
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