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van Doorn, M. (author), Vogels, J. (author), Tas, A. (author), van Hoogdalem, E.J. (author), Burggraaf, J. (author), Cohen, A. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
Aims: To explore the usefulness of metabolomics as a method to obtain a broad array of biomarkers for the pharmacological effects of rosiglitazone (RSG) in plasma and urine samples from patients with type 2 diabetes mellitus (T2DM) and healthy volunteers (HVs). Additionally, we explored the differences in metabolite concentrations between T2DM...
article 2007
document
Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.P.H.T.M. (author), Horbach, G.J. (author), Smit, M.J. (author), Zandberg, P. (author), Mellema, J.R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)
1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were administered at five single oral dosages between 2 and 500 mg/kg and between 6 and 1800 mg/kg,...
article 2007
document
Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.-P.H.T.M. (author), Smit, M.J. (author), Zandberg, P. (author), Horbach, G.J. (author), Mellema, J.-R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)
A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition is proposed for early detection of toxicity of investigational compounds in rats. The method is applied to detect toxicity upon administration of 13 toxic reference compounds and one nontoxic control compound (mianserine) in rats. The toxic compounds are...
article 2007
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Tas, A. (author), Venema, K. (author), W├╝lfert, F. (author), Vogels, J. (author), Nijssen, B. (author), TNO Voeding (author)
article 2002
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Vogels, J.T.W.E. (author), Terwel, L. (author), Tas, A.C. (author), van den Berg, F. (author), Dukel, F. (author), van der Greef, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
This paper describes the application of proton NMR spectroscopy as a screening tool for the determination of the authenticity of orange juices. Principal component and discriminant analyses were used to discriminate between authentic and nonauthentic (suspect) samples. In one set of profiles, additions of sucrose, beet medium invert sugar,...
article 1996
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Vogels, J.T.W.E. (author), Tas, A.C. (author), Venekamp, J. (author), van der Greef, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
NMR spectroscopy is increasingly used in combination with multivariate analysis applications. Especially in the analysis of food products and the study of natural processes it has proved its usefulness. The samples used in these evaluations are however, often difficult to control. 'Positional' shifts of peaks due to differences in pH and other...
article 1996
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Vogels, J. (author), Venekamp, J. (author), Tas, A. (author), TNO Voeding (author)
article 1996
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Vogels, J.T.W.E. (author), Arts, C.J.M. (author), Tas, A.C. (author), van Baak, M.J. (author), van der Greef, J. (author), TNO Voeding (author)
conference paper 1996
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