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Hoekstra, J.A. (author)
Continuous treatment application and changeover designs are both practised in milk production research. Continuous treatment trials require large numbers of animals to achieve sufficient precision due to the large variability between dairy cows. Changeover trials are relatively more precise, but result in biased estimates if certain assumptions...
article 1987
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Prangé, R. (author), Duban, M. (author), Vidal-Madjar, A. (author), Barnstedt, J. (author), Parisot, D. (author), Decaudin, M. (author), Crussaire, J.P. (author), Laurent, C. (author), Labèque, A. (author), Ancourt, G. (author), Flamand, J. (author), Grewing, M. (author), Hoekstra, R. (author), Thévenon, A. (author), Bargot, G. (author), Barthélémy, M. (author), Canovas, F. (author), Charra, C. (author), Hallier, C. (author), Lagardère, H. (author), Levanti, G. (author), Michaud, G. (author), Poncet, H. (author), Technisch Physische Dienst TNO - TH (author)
We have performed theoretical determination and experimental calibrations ofan objective grating designed for high resolution spectroscopy of astronomical faint sources in the EUV and far-UV wavelength ranges (500-1400 Á). First through theoretical calculations we show the feasibility of the concept with an aspheric shape for the grating blank...
article 1989
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Hoekstra, R. (author), Technisch Physische Dienst TNO - TH (author)
De redactie van Telescopium heeft mij als Principal Investigator van de Utrecht Echelle Spectrograaf UES gevraagd wat te vertellen over het project, dat in nauwe samenwerking tussen Utrecht, Roden, en Dwingeloo wordt gerealiseerd. De UES wordt ontwikkeld voor de William Herschel Telescoop op La Palma in het kader van de Brits—Nederlandse...
article 1989
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Hoekstra, R. (author), Technisch Physische Dienst TNO - TH (author)
Talking about spaceflight is talking about frontiers. Space technology can also be considered as a frontier, as it is well illustrated by the many challenges it imposes on design, materials, technology, accuracy, reliability and management. The TNO Institute of Applied Physics (TPD, Deft, the Netherlands) has contributed to pushing these frontiers.
article 1990
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Goede, A.P.H. (author), Aarts, H.J.M. (author), van Baren, C. (author), Burrows, J.P. (author), Change, K.V. (author), Hoekstra, R. (author), Hölzle, E. (author), Pitz, W. (author), Schneider, W. (author), Smorenburg, C. (author), Visser, H. (author), de Vries, J. (author), Technisch Physische Dienst TNO - TH (author)
The primary scientific objective of SCIAMACHY (Scanning Imaging Absorption Spectrometer for Atmospheric Chartography) is the global measurement of trace gases in the troposphere and the stratosphere. SCIAMACHY comprises two high resolution optical spectrometers scanning the atmosphere simultaneously in nadir and in limb. It retrieves the...
article 1991
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Hoekstra, S. (author), van Zijderveld, M.H. (author), Heidekamp, F. (author), van der Mark, F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Donor plants of Hordeum vulgare L. cv. Igri were grown in a conditioned environment to minimise fluctuations in the composition of the microspore population. After isolation different types of microspores were identified within each population, amongst others an embryogenic subpopulation. It was shown that the optimum plating density is achieved...
article 1993
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Hoekstra, S. (author), van Bergen, S. (author), van Brouwershaven, I.R. (author), Schilperoort, R.A. (author), Heidekamp, F. (author), TNO Voeding (author)
The influence of 2,4-dichlorophenoxyacetic acid (2,4-D) on embryo-like structures (ELS) and plant development from barley microspores was determined. Microspores cultured on filters enabled simple modification of growth regulator concentrations. Regeneration frequencies obtained with 2,4- D as growth regulator were similar to the results...
article 1996
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Hoekstra, E.J. (author), de Leer, E.D.W.B. (author), Brinkman, U.A.T.H. (author), TNO Milieu, Energie en Procesinnovatie (author)
We studied the occurrence of halogenated organic compounds in soil air of rural areas. Chloroform appeared to occur in elevated concentrations compared tO those in atmospheric air, while the concentrations of other chlorinated solvents were almost equal or lower than those in atmospheric air. We report conclusive evidence that chloroform is...
article 1998
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Wang, M. (author), Hoekstra, S. (author), van Bergem, S. (author), Lamers, G.E.M. (author), Oppedijk, B.J. (author), van der Heijden, M.W. (author), de Priester, W. (author), Schilperoort, R.A. (author)
article 1999
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Wang, M. (author), Hoekstra, S. (author), van Bergen, S. (author), Lamers, G.E.M. (author), Oppedijk, B.J. (author), van der Heijden, M.W. (author), de Priester, W. (author), Schilperoort, R.A. (author), Centrum voor Plantenfysiologisch Onderzoek (author)
Intra-nucleosomal cleavage of DNA into fragments of about 200 bp was demonstrated to occur in developing anthers, in which microspores had developed into the mid-late to late uni-nucleate stage in situ, i.e. at the verge of mitosis. The same was observed, but to a much larger extent, if these anthers were pre-treated by a hyper-osmotic shock....
article 1999
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Hoekstra, E.J. (author), de Leer, E.W.B. (author), Brinkman, U.A.T. (author), TNO Milieu, Energie en Procesinnovatie (author)
Since the ban on the use of trichloroacetic acid (TCAA) as a herbicide in several countries, TCAA is still found ubiquitously in the environment. The presence of TCAA nowadays is suggested to originate mainly from the atmospheric degradation of tetrachloroethene. Our mass balance calculations indicate that this may be true for the presence of...
article 1999
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Hoekstra, E.J. (author), Duyzer, J.H. (author), de Leer, E.W.B. (author), Brinkman, U.A.Th. (author)
Since we demonstrated the natural formation of chloroform in soil, the question arose to which extent this contributes to the chloroform present in the atmosphere. Concentration gradients in soil air and atmospheric air of different forests were measured. Chloroform concentration gradients indicating emission occur in forest soils and the...
article 2001
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ter Bogt, N.C.W. (author), Hoekstra, T. (author), Roest, M. (author), van de Vijver, L.P.L. (author), Verhoef, P. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
article 2004
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TNO Kwaliteit van Leven (author), Grefhorst, A. (author), Hoekstra, J. (author), Derks, T.G.J. (author), Ouwens, D.M. (author), Baller, J.F.W. (author), Havinga, R. (author), Havekes, L.M. (author), Romijn, J.A. (author), Kuipers, F. (author)
Accumulation of triglycerides (TG) in the liver is generally associated with hepatic insulin resistance. We questioned whether acute hepatic steatosis induced by pharmacological blockade of β-oxidation affects hepatic insulin sensitivity, i.e., insulin-mediated suppression of VLDL production and insulin-induced activation of phosphatidylinositol...
article 2005
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Wiefferink, C.H. (author), Peters, L. (author), Hoekstra, F. (author), Ten Dam, G. (author), Buijs, G.J. (author), Paulussen, T.G.W.M. (author), TNO Kwaliteit van Leven (author)
Characterizing school health promotion is its category-by-category approach, in which each separate health-related behavior is addressed independently. Such an approach creates a risk that extra-curricular activities become overloaded, and that teaching staff are distracted by continuous innovations. Within the health promotion sector there are...
article 2006
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Paulussen, T.G.W. (author), Hoekstra, F. (author), Lanting, C.I. (author), Buijs, G.B. (author), Hirasing, R.A. (author), TNO Preventie en Gezondheid (author)
This study examines the factors that influence parents' decisions to have their children vaccinated under the Dutch National Immunisation Programme. A computer questionnaire was sent to 500 parents in 1999 (the response rate was 98.2%). The intention to vaccinate was most strongly determined by attitudes. The belief that vaccination is safe and...
article 2006
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Post, S.M. (author), Groenendijk, M. (author), van der Hoogt, C.C. (author), Fievet, C. (author), Luc, G. (author), Hoekstra, M. (author), Princen, H.M.G. (author), Staels, B. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE - High-density lipoprotein (HDL) plays a key role in protection against development of atherosclerosis by reducing inflammation, protecting against LDL oxidation, and promoting reverse cholesterol transport from peripheral tissues to the liver for secretion into bile. Cholesterol 7α-hydroxylase (Cyp7a1) catalyzes the rate-limiting step...
article 2006
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TNO Kwaliteit van Leven (author), Reijneveld, S.A. (author), Vogels, A.G.C. (author), Hoekstra, F. (author), Crone, M.R. (author)
article 2006
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Flinterman, A.E. (author), van Hoffen, E. (author), den Hartog Jager, C.F. (author), Koppelman, S. (author), Pasmans, S.G. (author), Hoekstra, M.O. (author), Bruijnzeel-Koomen, C.A. (author), Knulst, A.C. (author), Knol, E.F. (author), TNO Kwaliteit van Leven (author)
Background: In peanut-allergic adults, IgE is mainly directed to Ara h1 and Ara h2. More recently, a role for Ara h6 has been suggested. In contrast to adults, IgE in children can fluctuate over time. Therefore, children may have a more dynamic reactivity to peanut. Objective: To examine the IgE reactivity to major peanut allergens in peanut...
article 2007
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TNO Kwaliteit van Leven (author), van der Hoogt, C.C. (author), de Haan, W. (author), Westerterp, M. (author), Hoekstra, M. (author), Dallinga-Thie, G.M. (author), Romijn, J.A. (author), Princen, H.M.G. (author), Jukema, J.W. (author), Havekes, L.M. (author), Rensen, P.C.N. (author)
In addition to efficiently decreasing VLDL-triglycerides (TGs), fenofibrate increases HDL-cholesterol levels in humans. We investigated whether the fenofibrate-induced increase in HDL-cholesterol is dependent on the expression of the cholesteryl ester transfer protein (CETP). To this end, APOE*3-Leiden (E3L) transgenic mice without and with the...
article 2007
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