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Peters, M. (author), Appel, I. (author), Dankert, J. (author), Spronsen, F. (author), Claahsen-van der Grinten, H. (author), van Trotsenburg, P. (author), Dekkers, E. (author), Elvers, B. (author), Loeber, G. (author), Rijpstra, A. (author), Verkerk, P. (author)
bookPart 2015
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Solazzo, E. (author), Bianconi, R. (author), Vautard, R. (author), Appel, K.W. (author), Moran, M.D. (author), Hogrefe, C. (author), Bessagnet, B. (author), Brandt, J. (author), Christensen, J.H. (author), Chemel, C. (author), Coll, I. (author), Denier van der Gon, H.A.C. (author), Ferreira, J. (author), Forkel, R. (author), Francis, X.V. (author), Grell, G. (author), Grossi, P. (author), Hansen, A.B. (author), Jeričević, A. (author), Kraljević, L. (author), Miranda, A.I. (author), Nopmongcol, U. (author), Pirovano, G. (author), Prank, M. (author), Riccio, A. (author), Sartelet, K.N. (author), Schaap, M. (author), Silver, J.D. (author), Sokhi, R.S. (author), Vira, J. (author), Werhahn, J. (author), Wolke, R. (author), Yarwood, G. (author), Zhang, J. (author), Rao, S. (author), Galmarini, S. (author)
More than ten state-of-the-art regional air quality models have been applied as part of the Air Quality Model Evaluation International Initiative (AQMEII). These models were run by twenty independent groups in Europe and North America. Standardised modelling outputs over a full year (2006) from each group have been shared on the web-distributed...
article 2012
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Peters, M. (author), Appel, I.M. (author), Cnossen, M.H. (author), Breuning-Boers, J.M. (author), Heijboer, H. (author), TNO Kwaliteit van Leven (author)
JGZ.
article 2009
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Tulley, R.T. (author), Appel, M.J. (author), Enos, T.G. (author), Hegsted, M. (author), Mccutcheon, K.L. (author), Zhou, J. (author), Raggio, A.M. (author), Jeffcoat, R. (author), Birkett, A. (author), Martin, R.J. (author), Keenan, M.J. (author), TNO Kwaliteit van Leven (author)
Energy values of high amylose corn starches high in resistant starch (RS) were determined in vivo by two different methodologies. In one study, energy values were determined according to growth relative to glucose-based diets in rats fed diets containing RS2, heat-treated RS2 (RS2-HT), RS3, and amylase predigested versions to isolate the RS...
article 2009
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Peters, M. (author), Appel, I.M. (author), Cnossen, M.H. (author), Breuning-Boers, J.M. (author), Heijboer, H. (author)
Doel Evalueren van de uitkomsten van het eerste jaar na invoering van de uitbreiding van de landelijke hielprikscreening met sikkelcelziekte (SCZ). Opzet Prospectieve landelijke registratie van kinderen met vermoedelijk SCZ of een andere vorm van ernstige hemoglobinopathie. Methode De bloedspots werden geanalyseerd met een...
article 2009
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Tomaso, H. (author), Jacobs, D. (author), Eickhoff, M. (author), Scholz, H.C. (author), al Dahouk, S. (author), Kattar, M.M. (author), Reischl, U. (author), Plicka, H. (author), Strand Olsen, J. (author), Nikkari, S. (author), Matero, P. (author), Beuret, C. (author), Ciammaruconi, A. (author), Lista, F. (author), Gala, J.-L. (author), Broll, H. (author), Appel, B. (author), Sellek Cano, R.E. (author), Ybarra de Villavicencio, M.D.C. (author), Broekhuijsen, M.P. (author), Indra, A. (author), Petersen, R. (author), Neubauer, H. (author)
Background: Yersinia pestis (Y. pestis) is a zoonotic bacterium mainly circulating among rodents and their fleas. Transmission to humans can cause bubonic, pneumonic or septicemic plague with a high case-fatality rate. Therefore, rapid and reliable diagnostic tools are crucial. The objective of this study was to assess the inter-laboratory...
article 2008
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Dekkers, S. (author), Telman, J. (author), Rennen, M.A.J. (author), Appel, M.J. (author), Buist, H.E. (author), de Heer, C. (author)
article 2006
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Dekkers, S. (author), Telman, J. (author), Rennen, M.A.J. (author), Appel, M.J. (author), de Heer, C. (author), TNO Industrie en Techniek TNO Kwaliteit van Leven (author)
In this study, the within-animal variation in routinely studied continuous toxicological parameters was estimated from temporal fluctuations in individual healthy nonexposed animals. Assuming that these fluctuations are nonadverse, this within-animal variation may be indicative of the minimal magnitude of the critical effect size (CES). The CES...
article 2006
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Appel, M.J. (author), van Veen, H.A. (author), Vietsch, H. (author), Salaheddine, M. (author), Nuijens, J.H. (author), Ziere, B. (author), de Loos, F. (author), TNO Kwaliteit van Leven (author)
The oral toxicity of recombinant human lactoferrin (rhLF) produced in the milk of transgenic cows was investigated in Wistar rats by daily administration via oral gavage for 13 consecutive weeks, 7 days per week. The study used four groups of 20 rats/sex/dose. The control group received physiological saline and the three test groups received...
article 2006
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Appel, M.J. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The present study was performed to investigate the influence of fish oil on the genotoxic effects of azaserine, using the formation of micronucleated erythrocytes as a measure for the degree of initiating potency and the number and size of putative preneoplastic pancreatic atypical acinar cell foci (AACF) as a measure for the actual number of...
article 2004
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Arts, J.H.E. (author), Muijser, H. (author), Appel, M.J. (author), Kuper, C.F. (author), Bessems, J.G.M. (author), Woutersen, R.A. (author), TNO Voeding (author)
The subacute oral and inhalation toxicity of furfural vapour was studied in Fischer 344 rats to investigate whether route-to-route extrapolation could be employed to derive the limit value for inhalation exposure from oral toxicity data. Groups of 5 rats per sex were treated by gavage daily for 28 days at dose levels of 6-192 mg/kg bw/day, or...
article 2004
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Appel, M.J. (author), Kuper, C.F. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
A study was performed to provide data on the disposition, accumulation and toxicity of sodium iron EDTA in comparison with iron (II) sulfate in rats on administration via the diet for 31 and 61 days. Clinical signs, body weights, food consumption, food conversion efficiency, hematology, clinical chemistry and pathology of selected organs were...
article 2001
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Woutersen, R.A. (author), Appel, M.J. (author), van Garderen-Hoetmer, A. (author), Wijnands, M.V.W. (author), TNO Voeding (author)
Epidemiologic investigations have suggested a relationship between dietary fat intake and various types of cancer incidences. Furthermore, epidemiologic studies as well as studies with animal models have demonstrated that not only the amount but also the type of fat consumed is important. At present, the mechanism by which dietary fat modulates...
article 1999
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Bär, A. (author), Lina, B.A.R. (author), de Groot, D.M.G. (author), de Bie, B. (author), Appel, M.J. (author)
article 1999
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Woutersen, R.A. (author), Wolterbeek, A.P.M. (author), Appel, M.J. (author), van den Berg, H. (author), Goldbohm, R.A. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The safety of β-carotene was reassessed by evaluating the relevant literature on the beneficial and adverse effects of β-carotene on cancer and, in particular, by evaluating the results of toxicity studies. β- Carotene appeared neither genotoxic nor reprotoxic or teratogenic, and no signs of organ toxicity have been found in subacute, subchronic...
article 1999
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Woutersen, R.A. (author), Appel, M.J. (author), Garderen van -Hoetmer, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Previously performed short-term (4-month) studies demonstrated that vitamins C and E, β-carotene and selenium modulate growth of early putative preneoplastic acinar lesions induced in rat pancreas by azaserine. The present paper summarizes the results of long-term studies performed with azaserine-treated rats maintained on diets high in either β...
article 1999
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Wijnands, M.V.W. (author), Appel, M.J. (author), Hollanders, V.M.H. (author), Woutersen, R.A. (author), TNO Voeding (author)
The objective of this experiment was to compare the effects of diets with either a non-fermentable fibre source (cellulose) or a fermentable fibre source [galacto-oligosaccharide (GOS)], combined with different levels of dietary fat, on the development of colorectal cancer. Male Wistar rats were fed AIN76-based diets with either a low or high...
article 1999
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Bär, A. (author), Lina, B.A.R. (author), de Groot, D.M.G. (author), de Bie, B. (author), Appel, M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
D-Tagatose is an incompletely absorbed ketohexose (stereoisomer of D-fructose) which has potential as an energy-reduced alternative sweetener. In an earlier 90-day toxicity study, rats fed diets with 10, 15 and 20% D-tagatose exhibited increased liver weights, but no histopathological alterations. To determine whether there might be any...
article 1999
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Woutersen, R.A. (author), Appel, M.J. (author), van Garderen-Hoetmer, A. (author)
article 1999
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Appel, M. (author), Woutersen, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1998
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