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Schlunk, F. (author), Fisher, P. (author), Princen, H.M.G. (author), Rex, A. (author), Prinz, V. (author), Foddis, M. (author), Lütjohann, D. (author), Laufs, U. (author), Endres, M. (author)
Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PSCK9) neutralizing antibodies effectively lower plasma cholesterol levels and decrease cardiovascular events but also raised some concern that cognitive function could worsen as a side effect. Here, we performed experiments in mice to characterize the effect of anti-PCSK9 antibodies...
article 2021
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Guffanti, S. (author), Visconti, C.G. (author), an Kampen, J. (author), Boon, J. (author), Groppi, G. (author)
Sorption Enhanced DiMethyl Ether Synthesis (SEDMES) is a promising option to overcome thermodynamic limitations of conventional DME production processes. In this work a 2D+1D heterogeneous dynamic model of the reaction/adsorption step in a tube of an externally cooled multitubular fixed bed SEDMES reactor is developed in order to investigate the...
article 2021
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Abokersh, M.H. (author), Spiekman, M.E. (author), Vijlbrief, O. (author), van Goch, T.A.J. (author), Vallies, M. (author), Boer, D. (author)
The nearly zero-energy buildings (nZEB) presents a promising contribution to fulfill the EU sustainable future targets. However, the construction industry that leads the development of nZEB is facing challenges to guarantee its performance. In this context, this paper proposes a methodology framework based on Multizone Resistance–Capacitance...
article 2021
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Kentrop, J. (author), Savransky, V. (author), Klaassen, S.D. (author), van Groningen, T. (author), Bohnert, S. (author), Cornelissen, A.S. (author), Cochrane, L. (author), Barry, J. (author), Joosen, M.J.A. (author)
Nerve agent exposure is generally treated by an antidote formulation composed of a muscarinic antagonist, atropine sulfate (ATR), and a reactivator of acetylcholinesterase (AChE) such as pralidoxime, obidoxime (OBI), methoxime, trimedoxime or HI-6 and an anticonvulsant. Organophosphates (OPs) irreversibly inhibit AChE, the enzyme responsible for...
article 2021
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Xiao, C. (author), Leeuwenburgh, O. (author), Lin, H.X. (author), Heemink, A. (author)
A reduced order modeling algorithm for the estimation of space varying parameter patterns in numerical models is proposed. In this approach domain decomposition is applied to construct separate approximations to the numerical model in every subdomain. We introduce a new local parameterization that decouples the computational cost of the...
article 2021
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Caron, J.F. (author), Bäumer, S.M.B. (author)
The aberrations of reflective optical systems with one plane of symmetry are investigated in the most general case, with freeform surfaces and possibly different locations of the tangential and sagittal object and image. In this first paper in a series of two, we establish generalized ray-tracing equations including transverse aberrations up to...
article 2021
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Caron, J.F. (author), Bäumer, S.M.B. (author)
The aberrations of reflective optical systems with planar symmetry are investigated in the most general case, with freeform surfaces and possibly different locations of the tangential and sagittal object and image. In this second and last paper, closed-form expressions are derived for the aberrations created by an individual mirror. We study two...
article 2021
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Fokker, P.A. (author), Borello, E.S. (author), Viberti, D. (author), Verga, F. (author), van Wees, J.D. (author)
Seasonal storage of heat in shallow aquifers for increasing the efficiency of geothermal energy systems requires a proper monitoring strategy. We expanded our earlier work on harmonic pulse testing (HPT) to incorporate the effect of a temperature front moving into the reservoir due to injection of hot (or cold) water. Our analytical solutions...
article 2021
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Weemstra, C. (author), de Laat, J.I. (author), Verdel, A. (author), Smets, P. (author)
Instrumental timing and phase errors are a notorious problem in seismic data acquisition and processing. These can be frequency independent, for example due to clock drift, but may also be frequency dependent, for example due to imperfectly known instrument responses. A technique is presented that allows both types of errors to be recovered in a...
article 2021
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Wolthuis, R. (author), Phillipson, F. (author), Jongsma, H.J. (author), Langenkamp, P.N. (author)
In recent years we see that an increasing amount of information becomes available that can be beneficial to the security risk process. Traditionally, security risk management is an asset-based, qualitative process based on expert opinion and information at hand; periodically a group of experts assesses applicable risks and determines correct...
article 2021
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Kaptein, F. (author), Broekens, J. (author), Hindriks, K. (author), Neerincx, M.A. (author)
Current developments in Artificial Intelligence (AI) led to a resurgence of Explainable AI (XAI). New methods are being researched to obtain information from AI systems in order to generate explanations for their output. However, there is an overall lack of valid and reliable evaluations of the effects on users' experience of, and behavior in...
article 2021
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van den Berge, M. (author), van der Beek, A.J. (author), Türkeli, R. (author), van Kalken, M. (author), Hulsegge, G. (author)
Objective: This study investigated associations between the co-existence of multiple types of work-related psychosocial and physical risk factors, and (1) obesity; (2) smoking; and (3) leisure-time physical inactivity. It also aimed to identify sociodemographic characteristics related to clustering of work-related risk factors and lifestyle...
article 2021
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Liakakou, E.T. (author), Infantes, A. (author), Neumann, A. (author), Vreugdenhil, B.J. (author)
The integration of gasification with syngas fermentation is still in an early stage of development, where many questions exist concerning the syngas quality required. The challenge is to define the gasification conditions that will provide a H2:CO:CO2 ratio suitable for syngas fermentation, as well as to identify and remove the compounds that...
article 2021
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Dekker, R. (author), van der Meer, F.P. (author), Maljaars, J. (author), Sluys, L.J. (author)
A numerical model for corrosion pit propagation under mechanical loading is presented. The level set method is used for corrosion front tracking and also enables the domain to be split into a solid and a pit domain. In the pit the diffusion of atoms originating from the dissolution process occurring at the pit front is simulated. The model is...
article 2021
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Andrianou, X.D. (author), Pronk, A. (author), Galea, K.S. (author), Stierum, R. (author), Loh, M. (author), Riccardo, F. (author), Pezzotti, P. (author), Makris, K.C. (author)
The COVID-19 pandemic placed public health measures against infectious diseases at the core of global health challenges, especially in cities where more than half of the global population lives. SARS-CoV-2 is an exposure agent recently added to the network of exposures that comprise the human exposome, i.e. the totality of all environmental...
article 2021
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Sögütoglu, L.-C. (author), Birkelbach, F. (author), Werner, A. (author), Fischer, H. (author), Huinink, H. (author), Adan, O.C.G. (author)
K2CO3 is a promising salt for thermochemical heat storage. For a high performance, the thermochemical reaction must take place as close as possible to the equilibrium, while ensuring sufficient reaction rates. In this work, we studied the near-equilibrium hydration kinetics of K2CO3 and other salts (CuCl2, MgCl2 and LiCl). We proposed a generic...
article 2021
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Pak, K. (author), Kooij, D.T.A.M. (author), de Lange, A.H. (author), van den Heuvel, S.G. (author), Veldhoven, M.J.P.M. (author)
Organisations are challenged to extend working lives of older workers. However, there is little empirical evidence available on how organisations should do this. This study aims to fill this gap by testing the effect of Human Resource (HR) practices on perceived work ability and the preferred retirement age. Based on the Conversation of...
article 2021
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Fransen, R.W. (author), Tilanus, P.A.J. (author), de Jong, J. (author), Davydenko, I. (author)
The SWARMPORT project modeled the infrastructure and the nautical services chain of the Port of Rotterdam as an Agent-based Simulation Model (ABSM). This ABSM can be used in scenario-wise studies on the effect of alternative behavior of stakeholders in the nautical services chain and its impact on a number of Key Performance Indicators (KPIs) of...
report 2021
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Memelink, R.G. (author), Pasman, W.J. (author), Bongers, A. (author), Tump, A. (author), van Ginkel, A. (author), Tromp, W. (author), Wopereis, S. (author), Verlaan, S. (author), den Bosch, J.V.V. (author), Weijs, P.J.M. (author)
Background: Weight loss is key to treatment of older adults with obesity and type 2 diabetes, but also a risk for muscle mass loss. This study investigated whether a whey protein drink enriched with leucine and vitamin D could preserve muscle mass and improve glycemic control during combined lifestyle intervention in this population. Methods:...
article 2021
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de Wolff, M.S. (author), Detmar, S.B. (author), Verkerk, P.H. (author), Reijneveld, S.A. (author), Geerdes-Maas, T. (author)
Het doel van deze opdracht is een beknopte en gedragen set van JGZ indicatoren te ontwikkelen, die gezamenlijk een goed beeld geven van de ontwikkeling en gezondheid van alle jeugdigen in Nederland tussen 0 en 18 jaar. Drie vragen staan centraal : 1. Welke indicatoren vinden JGZ-professionals en beleidsmakers het meest relevant voor de...
report 2021
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