Title
Prevalentie van bloedingen door vitamine k-tekort in Nederland, 1992-1994 [Prevalence of vitamin K deficiency bleeding in the Netherlands, 1992-1994]
Author
Cornelissen, E.A.M.
Hirasing, R.A.
Monnens, L.A.H.
TNO Preventie en Gezondheid
Publication year
1996
Abstract
Objective. To determine the prevalence of vitamin K deficiency bleeding in the Netherlands, in order to evaluate the efficacy of recommendations on vitamin K prophylaxis. Design. Descriptive. Setting. University Hospital Nijmegen, the Netherlands. Methods. Active surveillance of vitamin K deficiency bleeding (VKDB) by the Dutch Paediatric Surveillance Unit from October 1, 1992 to December 31, 1994. Results. Of the 19 reported cases 5 could be validated as late vitamin K deficiency bleeding: 2 idiopathic cases, and 3 secondary cases due to liver disorders. One case had intracranial bleeding and died. None of the cases had received exactly the recommended prophylaxis. The incidence of late VKDB was calculated to be 1.1/100,000 live births. Before vitamin K prophylaxis was recommended the incidence was estimated to be 7/100,000. Conclusion. The present Dutch recommendations for prevention of vitamin K deficiency bleeding - 1 mg vitamin K at birth and there after for breastfed infants daily 25 μg from 2 to 13 weeks - appear effective. Chemicals/CAS: Vitamin K, 12001-79-5
Subject
Health
Menadione
Bleeding
Child
Idiopathic disease
Intramuscular drug administration
Newborn
Oral drug administration
Cerebral Hemorrhage
Epistaxis
Hematemesis
Humans
Infant
Infant, Newborn
Vitamin K
Vitamin K Deficiency
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TNO identifier
233297
ISSN
0028-2162
Source
Nederlands Tijdschrift voor Geneeskunde, 140 (17), 935-937
Document type
article