Title
Quantifiable risk–benefit assessment of micronutrients: From theory to practice
Author
Krul, L.
Kremer, B.H.A.
Lucas Luijckx, N.B.
Leeman, W.R.
Publication year
2017
Abstract
The EU Food Supplements Directive (2002/46/EC) mandates the determination of both maximum and minimum permitted levels (MPLs) for micronutrients. In order to determine MPLs which are feasible for particular population groups, a scientific approach should be used in which risk of high intake, risk of inadequacy and benefits are assessed in an integrated way taking all available data and severity and incidence of effect into account. In 2004, Renwick et al. (ILSI Europe) published a scientifically valid, flexible and pragmatic basis for a risk–benefit approach, which has been further developed here to make it a practical and quantifiable approach to be used by risk managers. The applicability of the approach is demonstrated using demo cases on iron and folate. The proposed approach has the capacity to utilize all relevant data available, including data from human studies, bioavailability data showing variability between specific forms of micronutrients and, in the case of animal studies, data on species comparability. The approach is therefore both practical and flexible, making it well suited to risk managers tasked with determining safe intake levels for micronutrients in different forms and for particular population groups. © 2017 The Author(s). Published by Taylor & Francis Group, LLC © 2017, © Lisette Krul, Bas H. A. Kremer, Niels B. Lucas Luijckx, and Winfried R. Leeman.
Subject
ELSS - Earth, Life and Social Sciences
Life
Healthy Living
Food and Nutrition
Food supplements
Risk–benefit
Biochemistry
Managers
Nutrients
Population statistics
Risk assessment
Trace elements
Animal studies
Benefit assessments
Bioavailability
Food supplements
Human study
Risk manager
Vulnerable population
Risk management
RAPID - Risk Analysis for Products in Development
To reference this document use:
http://resolver.tudelft.nl/uuid:f337f61f-f7e9-4c6d-a63b-61fa48fbb7b8
DOI
https://doi.org/10.1080/10408398.2016.1162765
TNO identifier
766524
ISSN
1040-8398
Source
Critical Reviews in Food Science and Nutrition, 57 (57), 3729-3746
Document type
article