Title
Effect of fortified spread on homocysteine concentration in apparently healthy volunteers
Author
van Vliet, T.
Jacobs, R.G.J.M.
de Deckere, E.
van den Berg, H.
de Bree, A.
van der Put, N.M.J.
TNO Kwaliteit van Leven
Publication year
2007
Abstract
Objective: To determine the effect of folic acid, vitamin B6 and B12 fortified spreads on the blood concentrations of these vitamins and homocysteine. Design and setting: A 6-week randomized, double-blinded, placebo-controlled, parallel trial carried out in a clinical research center. Subjects: One hundred and fifty healthy volunteers (50% males). Interventions: For 6 weeks, the subjects consumed the test spreads (20 g/day): containing per 20 g (1) 200μ g folic acid, 2μ g vitamin B12 and 1 mg vitamin B6, or (2) 400μ g folic acid, 2μ g vitamin B12 and 1 mg vitamin B6 or (3) no B-vitamins (control spread). Results: The B-vitamin status increased on using the test spreads, with the largest effect on the serum folate concentration: 48% in men and 58% in women on spread 1 and 92 and 146%, respectively, on spread 2 (P-values all <0.05). The plasma homocysteine decreased in the groups treated with the fortified spreads as compared to the control group. Average decreases were for males: 0.7±1.5±μmol/l (6.8%) on spread 1 and 1.7 ± 1.7 μmol/l (17.6%) on spread 2 and for females: 1.4 ± 1.2 μmol/l (14.2%) and 2.4 ± 2.0 μmol/l (23.3%), respectively (P-values all <0.05). Conclusions: Consumption of a spread fortified with folic acid, vitamin B6 and vitamin B12 for 6 weeks significantly increases the blood concentrations of these vitamins and significantly decreases the plasma concentration of homocysteine. Fortified staple foods like spreads can contribute to the lowering of homocysteine concentrations.
Subject
Health
Biomedical Research
cyanocobalamin
folic acid
homocysteine
pyridoxine
vitamin B complex
adult
aged
amino acid blood level
article
clinical research
clinical trial
controlled study
double blind procedure
female
folic acid blood level
food intake
human
male
normal human
parallel design
randomized controlled trial
vitamin blood level
vitamin supplementation
volunteer
adolescent
blood
controlled clinical trial
diet supplementation
diet therapy
dose response
hyperhomocysteinemia
middle aged
sex difference
Adolescent
Adult
Aged
Dose-Response Relationship, Drug
Double-Blind Method
Female
Folic Acid
Food, Fortified
Homocysteine
Humans
Hyperhomocysteinemia
Male
Middle Aged
Sex Factors
Vitamin B 12
Vitamin B 6
Vitamin B Complex
To reference this document use:
http://resolver.tudelft.nl/uuid:f05c3f14-b855-4022-beb3-abe239f14841
DOI
https://doi.org/10.1038/sj.ejcn.1602570
TNO identifier
240013
ISSN
0954-3007
Source
European Journal of Clinical Nutrition, 61 (6), 769-778
Document type
article