Print Email Facebook Twitter Antigen-specific therapies in multiple sclerosis Title Antigen-specific therapies in multiple sclerosis Author van Noort, J.M. TNO Preventie en Gezondheid Publication year 1998 Abstract Multiple sclerosis is the major neurological disease of young adults in the western world, affecting about 1 per 1,000. It is characterised by chronic or recurrent lesions of inflammatory damage in the white matter of the central nervous system. Within such lesions, the protective myelin sheath is stripped off axons by infiltrated macrophages which leads to impaired conductivity. The inflammatory process most likely starts by activation of helper T cells directed against local myelin antigens. Currently, efforts are directed at specifically blocking such myelin-reactive helper T cells in order to control the disease. In this chapter, immunological features of multiple sclerosis and the experimental animal model for the disease, experimental allergic encephalomyelitis, are discussed. Next, an overview is presented on myelin antigens that have been suggested to play a role as target antigens in MS. Finally, strategics are discussed that arc currently employed to selectively block the activation of T-cells reactive against myclin antigens. Subject HealthAntigen-specific theraphyAutoimmunityMultiple sclerosisAdultAnimalsAntigensAutoantigensEncephalomyelitis, Autoimmune, ExperimentalHumansImmune ToleranceImmunotherapyLymphocyte ActivationMajor Histocompatibility ComplexModels, BiologicalMultiple SclerosisMyelin ProteinsT-Lymphocytes To reference this document use: http://resolver.tudelft.nl/uuid:e81127a7-0cf8-428b-b797-65e8eaab924a TNO identifier 234438 ISSN 0921-299X Source Biotherapy, 10 (3), 237-250 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.