Title
Embryotoxicity and teratogenicity study with α-cyclodextrin in rats
Author
Waalkens-Berendsen, D.H.
Bär, A.
TNO Voeding
Publication year
2004
Abstract
The embryotoxicity/teratogenicity of α-cyclodextrin (α-CD) was examined in Wistar Crl:(WI)WU BR rats. α-CD was fed at dietary concentrations of 0, 1.5, 5, 10, or 20% to groups of 25 pregnant female rats from day 0 to 21 of gestation. An additional group received a diet with 20% lactose. The additions to the diet of α-CD and lactose were made at the expense of pregelatinized potato starch. Body weight as well as food and water intake were recorded during the treatment period. The rats were killed on day 21 and examined for standard parameters of maternal reproductive performance. The fetuses were examined for external abnormalities, body weight and crown rump length. Fetuses were examined for skeletal and visceral abnormalities. Generally, α-CD was well tolerated and no deaths occurred in any group. Weight gain and food consumption were similar in all groups during gestation, except for a slightly yet significantly increased food intake in the 20% α-CD group from day 6 to 21. Water intake was similar in all α-CD groups; in the lactose group, it was significantly higher than in the controls. Maternal reproductive performance was not affected by the α-CD treatment. Examination of the fetuses for external, visceral and skeletal changes did not reveal any fetotoxic, embryotoxic, or teratogenic effects of α-CD. In conclusion, no adverse effects were observed at α-CD intakes of up to 20% of the diet, the highest dose level tested at which the rats consumed about 13g/kg bw/day. © 2004 Elsevier Inc. All rights reserved.
Subject
Biology
Toxicology and Applied Pharmacology
alpha cyclodextrin
lactose
starch
animal experiment
animal model
animal tissue
article
chemical teratogenesis
controlled study
crown rump length
embryotoxicity
female
fetotoxicity
fetus disease
fetus weight
fluid intake
food intake
gestation period
gestational age
medical assessment
nonhuman
priority journal
rat
rat strain
sexual behavior
species comparison
teratogenicity
weight gain
Abnormalities, Drug-Induced
Administration, Oral
alpha-Cyclodextrins
Animals
Cyclodextrins
Embryonic and Fetal Development
Female
Male
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Rats, Wistar
Solanum tuberosum
To reference this document use:
http://resolver.tudelft.nl/uuid:e75a0452-61fd-457a-b257-20c7be64e4c3
DOI
https://doi.org/10.1016/j.yrtph.2004.05.004
TNO identifier
237795
ISSN
0273-2300
Source
Regulatory Toxicology and Pharmacology, 39 (SUPPL.)
Document type
article