Title
Screening for templates that promote crystallization
Author
Urbanus, J.
Roelands, C.P.M.
ter Horst, J.H.
Verdoes, D.
Jansens, P.J.
TNO Industrie
Publication year
2008
Abstract
In Situ Product Recovery (ISPR) applied in fermentation processes leads to improved yield and productivity of these processes. In principle, ISPR can be achieved using Template Induced Crystallization (TIC), which is one possible ISPR technique. With TIC, templates are added to the solution as a specific surface upon which the solute preferably crystallizes. The governing principles of TIC are poorly understood and template selection criteria are lacking. Therefore, a method to screen for these templates has been developed. The methodology comprises metastable zone width determination, template classification and induction time measurements. The screening method was implemented in robotized equipment for parallel experimentation. The new method uses induction time measurements to distinguish templates that induce crystallization from ineffective templates. The addition of TiO2 and ZrO2 templates decreased induction times of cinnamic acid crystallization. TiO2 and ZrO2 therefore appeared effective for Template Induced Crystallization. Colloidal gold nanoparticles increased induction times and therefore were ineffective templates for TIC. It was concluded that the methodology is an effective screening tool for potential templates for inducing pH-shift crystallization. Future work will be focused on gaining understanding of the relation between physical properties of templates and their effectivity. © 2008 The Institution of Chemical Engineers.
Subject
High throughput equipment
In Situ Product Recovery (ISPR)
Screening methodology
Sustainable processing
Template Induced Crystallization (TIC)
Colloid chemistry
Crystallization
Fermentation
Nanoparticles
Titanium dioxide
Zirconia
Cinnamic acid crystallization
Colloidal gold nanoparticles
Biochemistry
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TNO identifier
240830
ISSN
0960-3085
Source
Food and Bioproducts Processing, 86 (2), 116-121
Document type
article