Title
Relation between the faecal concentration of various potentially pathogenic microorganisms and infections in individuals (mice) with severely decreased resistance to infection
Author
van der Waaij, D.
Tieleman-Speltie, T.M.
Roeck de - Houben, A.M.J.
Radiobiologisch Instituut TNO
Publication year
1978
Abstract
Lethally irradiated conventional mice were killed at daily intervals after irradiation. A high correlation was found between the occurrence of bacterial over-growth in the digestive tract and invasion into the regional lymph nodes the spleen and the blood. By oral contamination of mice with quite high doses of either an exogenous or an endogenous biotype of an Enterobacteriaceae species at day 4 after irradiation, it was attempted to induce such condition of intestinal over-growth. In all animals such an abnormal colonization of the contaminant was indeed achieved in this way and the mice died from an infection caused by the biotype used for the contamination. The interval between contamination and death was different when different biotypes were used for contamination and occurred sooner after irradiation when an endogenous biotype was used for (re)contamination. It is concluded that oral contamination with exogenous as well as with endogenous potentially pathogenic bacteria during a period of severely decreased resistance to infections must be avoided. The colonization resistance of the digestive tract of these animals should be maintained as high as possible. © 1978 H. Veenman & Zonen B.V. Publishers.
Subject
X-ray
Animal
Enterobacteriaceae
Enterobacteriaceae Infections
Feces
Female
Immunity
Immunosuppression
Intestines
Mice
Species Specificity
X-Rays
To reference this document use:
http://resolver.tudelft.nl/uuid:dad911e7-1b0b-4909-9f97-0af5a36b069c
DOI
https://doi.org/10.1007/bf00394316
TNO identifier
228389
Publisher
Kluwer Academic Publishers
ISSN
0003-6072
Source
Antonie van Leeuwenhoek, 44 (3-4), 395-405
Document type
article