Print Email Facebook Twitter Challenges in simulating the human gut for understanding the role of the microbiota in obesity Title Challenges in simulating the human gut for understanding the role of the microbiota in obesity Author Aguirre, M. Venema, K. Publication year 2017 Abstract There is an elevated incidence of cases of obesity worldwide. Therefore, the development of strategies to tackle this condition is of vital importance. This review focuses on the necessity of optimising in vitro systems to model human colonic fermentation in obese subjects. This may allow to increase the resolution and the physiological relevance of the information obtained from this type of studies when evaluating the potential role that the human gut microbiota plays in obesity. In light of the parameters that are currently used for the in vitro simulation of the human gut (which are mostly based on information derived from healthy subjects) and the possible difference with an obese condition, we propose to revise and improve specific standard operating procedures. © 2016 Wageningen Academic Publishers. Subject LifeMSB - Microbiology and Systems BiologyELSS - Earth, Life and Social SciencesBiomedical InnovationBiologyHealthy LivingFermentationHuman obesityIntestinal microbiotaSimulation To reference this document use: http://resolver.tudelft.nl/uuid:d864f717-fa4c-452e-b402-ced85435d7ff DOI https://doi.org/10.3920/bm2016.0113 TNO identifier 745918 ISSN 1876-2883 Source Beneficial Microbes, 8 (1), 31-53 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.