Title
Body Mass Index and von Hippel-Lindau Gene Mutations in Clear-cell Renal Cancer: Results of the Netherlands Cohort Study on Diet and Cancer
Author
Smits, K.M.
Schouten, L.J.
Hudak, E.
Verhage, B.
van Dijk, B.A.C.
van de Hulsbergen - Kaa, C.A.
Goldbohm, R.A.
Oosterwijk, E.
van den Brandt, P.A.
TNO Kwaliteit van Leven
Publication year
2010
Abstract
Purpose: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC). A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene. We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which comprises 120,852 persons. Methods: After 11.3 years of follow-up, 337 incident RCC cases were identified; 185 cc-RCC cases were included for analyses. Results: A high BMI at baseline was associated with an increased risk of cc-RCC with or without VHL mutations (per 1 kg/m2: hazard ratio [HR] = 1.09, 95% confidence interval [CI]: 1.02-1.16 and HR = 1.08, 95%CI: 1.01-1.15, respectively). BMI at age 20 was only associated with an increased risk of cc-RCC with VHL mutations (per 1 kg/m2: HR =1.09, 95% CI: 1.03-1.16). In contrast, BMI gain since age 20 was only associated with an increased risk in VHL wild-type cases (per 1 kg/m2: HR = 1.10, 95% CI: 1.03-1.19). Conclusion: Our findings indicate that BMI may be differently associated with subtypes of RCC based on VHL mutations. © 2010 Elsevier Inc.
Subject
Health
Leefomgeving en gezondheid
Body Mass Index
Clear-cell Renal Cancer
VHL Mutations
von Hippel Lindau protein
adult
age
article
body mass
cancer risk
clear cell carcinoma
cohort analysis
controlled study
diet
female
gene mutation
human
kidney cancer
major clinical study
male
Netherlands
priority journal
prospective study
risk factor
weight gain
wild type
Adult
Body Mass Index
Carcinoma, Renal Cell
Cohort Studies
Confidence Intervals
Diet
Female
Humans
Kidney Neoplasms
Male
Middle Aged
Mutation
Netherlands
Nutritional Status
Risk Factors
von Hippel-Lindau Disease
Young Adult
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http://resolver.tudelft.nl/uuid:d75198dc-79fe-493f-88a8-5a31ca17686c
TNO identifier
408477
ISSN
1047-2797
Source
Annals of Epidemiology, 20 (5), 401-404
Document type
article