Analytical strategies in lipidomics and applications in disease biomarker discovery
article
Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes, obesity, atherosclerosis and Alzheimer's disease. Investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health. Recent technological advancements in mass spectrometry and rapid improvements in chromatographic techniques have led to the rapid expansion of the lipidomics research field. In this review, emphasis is given to the recent advances in lipidomics technologies and their applications in disease biomarker discovery. © 2009 Elsevier B.V. All rights reserved.
Topics
Analytical researchLipid profilingLipid-associated disordersAlzheimer's diseaseAnalytical strategyChromatographic techniquesComprehensive analysisDisease biomarkerHuman diseaseHuman healthLipidomicsMetabolomicsMolecular speciesRapid expansionResearch fieldsTechnological advancementBiological systemsBiomarkersLipidsMass spectrometryInformation managementBiological markerCeramideCholesterol esterGlycerophosphoethanolamineGlycerophosphorylcholineInositol phosphateLong chain triacylglycerolLysophosphatidylcholinePhosphatidylcholinePhosphoserineSulfatideAlzheimer diseaseAtherosclerosisChemical structureDiabetes mellitusDisease markerElectrospray mass spectrometryHigh performance liquid chromatographyHumanLipid analysisLipid metabolismLipidomicsLiquid chromatographyMass spectrometryMatrix assisted laser desorption ionization time of flight mass spectrometryNonhumanNuclear magnetic resonance spectroscopyObesityPriority journalReviewSensitivity and specificityThin layer chromatography
TNO Identifier
241760
DOI
https://dx.doi.org/10.1016/j.jchromb.2009.01.038
ISSN
15700232
Source
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 877(26), pp. 2836-2846.
Pages
2836-2846
Files
To receive the publication files, please send an e-mail request to TNO Repository.