Title
Analytical strategies in lipidomics and applications in disease biomarker discovery
Author
Hu, C.
van der Heijden, R.
Wang, M.
van der Greef, J.
Hankemeier, T.
Xu, G.
TNO Kwaliteit van Leven
Publication year
2009
Abstract
Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes, obesity, atherosclerosis and Alzheimer's disease. Investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health. Recent technological advancements in mass spectrometry and rapid improvements in chromatographic techniques have led to the rapid expansion of the lipidomics research field. In this review, emphasis is given to the recent advances in lipidomics technologies and their applications in disease biomarker discovery. © 2009 Elsevier B.V. All rights reserved.
Subject
Biology Health
Analytical research
Lipid profiling
Lipid-associated disorders
Alzheimer's disease
Analytical strategy
Chromatographic techniques
Comprehensive analysis
Disease biomarker
Human disease
Human health
Lipidomics
Metabolomics
Molecular species
Rapid expansion
Research fields
Technological advancement
Biological systems
Biomarkers
Lipids
Mass spectrometry
Information management
Biological marker
Ceramide
Cholesterol ester
Glycerophosphoethanolamine
Glycerophosphorylcholine
Inositol phosphate
Long chain triacylglycerol
Lysophosphatidylcholine
Phosphatidylcholine
Phosphoserine
Sulfatide
Alzheimer disease
Atherosclerosis
Chemical structure
Diabetes mellitus
Disease marker
Electrospray mass spectrometry
High performance liquid chromatography
Human
Lipid analysis
Lipid metabolism
Lipidomics
Liquid chromatography
Mass spectrometry
Matrix assisted laser desorption ionization time of flight mass spectrometry
Nonhuman
Nuclear magnetic resonance spectroscopy
Obesity
Priority journal
Review
Sensitivity and specificity
Thin layer chromatography
To reference this document use:
http://resolver.tudelft.nl/uuid:d595a105-85e4-46c3-9ca9-094481beec84
DOI
https://doi.org/10.1016/j.jchromb.2009.01.038
TNO identifier
241760
ISSN
1570-0232
Source
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 877 (26), 2836-2846
Document type
article