Title
Extractant selection strategy for solvent-impregnated resins in fermentations
Author
van den Berg, C.
Roelands, C.P.M.
Bussmann, P.J.Th.
Goetheer, E.L.V.
Verdoes, D.
van der Wielen, L.
TNO Kwaliteit van Leven TNO Separation Technolog
Publication year
2008
Abstract
The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P o/w values), product selectivity, and extractant regeneration. ©2008 American Chemical Society.
Subject
Chemistry
Extractants
Fermentation products
In-situ
Industrial fermentations
Product inhibitions
Product selectivities
Solvent-impregnated resins
Whole-cell biocatalysis
Biochemical engineering
Cell growth
Emulsification
Growth kinetics
Phenolic resins
Phenols
Resins
Impregnation
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http://resolver.tudelft.nl/uuid:d53ac9e8-97fb-4f7e-9ee5-06dc05e134a1
TNO identifier
241285
ISSN
0888-5885
Source
Industrial and Engineering Chemistry Research, 47 (24), 10071-10075
Document type
article