Print Email Facebook Twitter Extractant selection strategy for solvent-impregnated resins in fermentations Title Extractant selection strategy for solvent-impregnated resins in fermentations Author van den Berg, C. Roelands, C.P.M. Bussmann, P.J.Th. Goetheer, E.L.V. Verdoes, D. van der Wielen, L. TNO Kwaliteit van Leven TNO Separation Technolog Publication year 2008 Abstract The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P o/w values), product selectivity, and extractant regeneration. ©2008 American Chemical Society. Subject ChemistryExtractantsFermentation productsIn-situIndustrial fermentationsProduct inhibitionsProduct selectivitiesSolvent-impregnated resinsWhole-cell biocatalysisBiochemical engineeringCell growthEmulsificationGrowth kineticsPhenolic resinsPhenolsResinsImpregnation To reference this document use: http://resolver.tudelft.nl/uuid:d53ac9e8-97fb-4f7e-9ee5-06dc05e134a1 TNO identifier 241285 ISSN 0888-5885 Source Industrial and Engineering Chemistry Research, 47 (24), 10071-10075 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.