Print Email Facebook Twitter Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents Title Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents Author van den Dries, M.A. Lamballais, S. El Marroun, H. Pronk, A. Spaan, S. Ferguson, K.K. Longnecker, M.P. Tiemeier, H. Guxens, M. Publication year 2020 Abstract Background: Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine repeatedly measured during gestation are associated with brain morphology and white matter microstructure in 518 preadolescents aged 9–12 years. Method: Data came from 518 mother–child pairs participating in the Generation R Study, a population-based birth cohort from Rotterdam, the Netherlands. Maternal urine concentrations were determined for 6 dialkylphosphates (DAPs) including 3 dimethyl (DM) and 3 diethyl (DE) alkyl phosphate metabolites, collected at early, mid, and late pregnancy. At child's age 9–12 years, magnetic resonance imaging was performed to obtain T1-weighted images for brain volumes and surface-based cortical thickness and cortical surface area, and diffusion tensor imaging was used to measure white matter microstructure through fractional anisotropy (FA) and mean diffusivity (MD). Linear regression models were fit for the averaged prenatal exposure across pregnancy. Results: DM and DE metabolite concentrations were not associated with brain volumes, cortical thickness, and cortical surface area. However, a 10-fold increase in averaged DM metabolite concentrations across pregnancy was associated with lower FA (B = −1.00, 95%CI = −1.80, −0.20) and higher MD (B = 0.13, 95%CI = 0.04, 0.21). Similar associations were observed for DE concentrations. Conclusions: This study provides the first evidence that OP pesticides may alter normal white matter microstructure in children, which could have consequences for normal neurodevelopment. No associations were observed with structural brain morphology, including brain volumes, cortical thickness, and cortical surface area. © 2020 Elsevier Inc. Subject Organophosphate pesticidesPrenatal exposureMRIWhite matter microstructureBrain morphologyBiological developmentBrainConcentration (composition)MicrostructureNervous systemOrganophosphorus pesticidePollution exposureAdultBrain sizeChildCortical thickness (brain)Diffusion tensor imagingFemaleFractional anisotropyHumanKidney concentrating capacityMajor clinical studyMaleMetaboliteMotherNetherlandsNeuroimagingPopulation researchPregnancyPrenatal exposureSchool childSurface areaWhite matterAnimalia To reference this document use: http://resolver.tudelft.nl/uuid:d1459d89-d935-445c-a907-9529e673a335 DOI https://doi.org/10.1016/j.envres.2020.110047 TNO identifier 880302 Source Environmental Research, 191 Article number 110047 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.