Title
The association between IGF-1 polymorphisms, IGF-1 serum levels, and cognitive functions in healthy adults: The amsterdam growth and health longitudinal study
Author
Licht, C.M.M.
van Turenhout, L.C.
Deijen, J.B.
Koppes, L.L.J.
van Mechelen, W.
Twisk, J.W.R.
Drent, M.L.
Publication year
2014
Abstract
Several studies have demonstrated an association between polymorphisms in the insulin-like growth factor-1 (IGF-1) gene and IGF-1 serum levels. IGF-1 levels have been associated with cognitive functioning in older persons and growth hormone deficient patients. The present study investigates whether IGF-1 polymorphisms, IGF-1 levels, and cognition are interconnected in healthy adults. Data of 277 participants (mean age: 42.4 years) of the Amsterdam Growth and Health Longitudinal Study on IGF-1 promoter polymorphisms, IGF-1 serum level, spatial working memory (SWM), paired associate learning (PAL), and IQ tests were analyzed. (M)ANOVAs were applied to confirm the associations between IGF-1 polymorphisms and IGF-1 levels and between IGF-1 levels and cognition. Three groups were distinguished based on specific IGF-1 polymorphism alleles: a homozygote 192 bp/192 bp genotype, a heterozygote 192 bp/x genotype, and a noncarrier x/x genotype. Although different IGF-1 levels were found for the three genotypes, performance on all cognitive tasks and IQ measures was similar. Despite the associations between IGF-1 polymorphisms and IGF-1 levels, no association was found between cognition and IGF-1 levels. It seems that IGF-1 does not play a role in the cognitive performance of healthy middle-aged adults. Possible, IGF-1 fulfills a more developmental and protective role in cognition which becomes apparent during childhood, old-age, or disease. © 2014 Carmilla M. M. Licht et al.
Subject
ELSS - Earth, Life and Social Sciences
Resilient Organisations
Healthy Living
Work and Employment
Somatomedin C
Adult
Body mass
Caucasian
Clinical assessment
Cognition
Gene frequency
Gene location
Genetic association
Genetic polymorphism
Heterozygote
Homozygote
Human experiment
IGF 1 gene
Intelligence quotient
Mental task
Mental test
Middle aged
Paired associate learning
Promoter region
Protein blood level
Spatial memory
Working memory
WHC - Work, Health and Care
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http://resolver.tudelft.nl/uuid:ce93df85-9c16-413b-a0e1-256cda04bfe0
DOI
https://doi.org/10.1155/2014/181327
TNO identifier
513417
ISSN
1687-8345
Source
International Journal of Endocrinology
Document type
article