Title
Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol
Author
Kühnast, S.
Louwe, M.C.
Heemskerk, M.M.
Pieterman, E.J.
van Klinken, J.B.
van den Berg, S.A.A.
Smit, J.W.A.
Havekes, L.M.
Rensen, P.C.N.
van der Hoorn, J.W.A.
Princen, H.M.G.
Jukema, J.W.
Publication year
2013
Abstract
Objective:Niacin potently lowers triglycerides, mildly decreases LDL-cholesterol, and largely increases HDL-cholesterol. Despite evidence for an atheroprotective effect of niacin from previous small clinical studies, the large outcome trials, AIM-HIGH and HPS2-THRIVE did not reveal additional beneficial effects of niacin (alone or in combination with laropiprant) on top of statin treatment. We aimed to address this apparent discrepancy by investigating the effects of niacin without and with simvastatin on atherosclerosis development and determine the underlying mechanisms, in APOE*3Leiden.CETP mice, a model for familial dysbetalipoproteinemia (FD).Approach and Results:Mice were fed a western-type diet containing cholesterol without or with niacin (120 mg/kg/day), simvastatin (36 mg/kg/day) or their combination for 18 weeks. Similarly as in FD patients, niacin reduced total cholesterol by -39% and triglycerides by -50%, (both P
Subject
EELS - Earth, Environmental and Life Sciences
Life
Healthy Living
Biomedical Innovation
Biology
MHR - Metabolic Health Research
To reference this document use:
http://resolver.tudelft.nl/uuid:cdffb5ff-590c-4606-90ae-1afd092d1e82
DOI
https://doi.org/10.1371/journal.pone.0066467
TNO identifier
474195
ISSN
1932-6203
Source
PLoS ONE, 8 (8)
Document type
article