Title
Standard operating procedure for immunuslotblot assay for analysis of DNA/sulfur mustard adducts in human blood and skin
Author
van der Schans, G.P.
Mars-Groenendijk, R.
de Jong, L.P.A.
Benschop, H.P.
Noort, D.
Publication year
2004
Abstract
A standard operating procedure has been developed for an immunoslotblot assay of sulfur mustard adducts to DNA in human blood and skin for use in a field laboratory. A minimum detectable level of exposure of human blood in vitro (≥ 50nM) sulfur mustard is feasible with the assay. In the case of human skin, a 1 s exposure to saturated sulfur mustard vapor (830 mg/m-3) could still be detected. Chemicals / CAS: mustard gas, 505-60-2; Chemical Warfare Agents; DNA Adducts; Mustard Gas, 505-60-2
Subject
Mustard gas
Blood analysis
Chemical analysis
DNA determination
Exposure
Human
Immunoblotting
Laboratory test
Southern blotting
Vapor
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TNO identifier
237862
ISSN
0146-4760
Source
Journal of Analytical Toxicology, 28 (28), 316-319
Document type
article