Title
Long-term gastrointestinal tolerance of NUTRIOSE®FB in healthy men
Author
Pasman, W.
Wils, D.
Saniez, M.H.
Kardinaal, A.
TNO Kwaliteit van Leven TNO Voeding
Publication year
2006
Abstract
Objective: To determine the gastrointestinal (GI) tolerance of NUTRIOSE®FB in men. Design: A randomized, placebo-contro lled, parallel, double-blind study. Setting: The metabolic ward of TNO Quality of Life. Subjects: Forty-eight subjects started the study: 16 men participated in one of the three treatments. Subjects consumed either 22.5 g of pure maltodextrin (Glucidex®6), or 30 or 45 g of the dextrin NUTRIOSE®FB daily for 4-5 weeks. Forty-three subjects completed the study (age: 34.7±8.2 years; BMI 24.9±3.3 kg m2). Measurements: Tolerance of NUTRIOSE®FB was examined with a GI complaints questionnaire; effectiveness on colonic flora was examined by faecal analysis; fermentation by breath hydrogen excretion measurement. Furthermore, the effect on body weight (BW), energy intake and blood parameters were examined in the study. Results: Both doses of NUTRIOSE®FB were very well tolerated and GI complaints hardly differed from the placebo treatment. No diarrhoea was reported due to NUTRIOSE®FB supplementation. In the course of the study, some habituation and adaptation of GI symptoms were found. Fermentation and faecal characteristics (pH and enzyme activity) were significantly positively affected with NUTRIOSE®FB treatment. Body weight in both NUTRIOSE®FB groups remained stable over time, although the placebo-treated group showed a small increase in BW (Δday35-1 0.8±1.0 kg) (P=0.07). However, total food intake and macronutrient composition of the diet remained the same throughout the study. No significant differences were found between the three treatment groups in hunger and satiety scores and food preferences. Conclusions: Long-term supplementation of 30 or 45 g of the dextrin NUTRIOSE®FB per day was well tolerated, and may act as a pre-biotic supplement.
Subject
Health
Biomedical research
Alpha glucosidase
Beta glucosidase
Cholesterol
Coprosterol
Glucidex
Glucose
Lactic acid
Maltodextrin
Nutriose fb
Placebo
Short chain fatty acid
Sitosterol
Absence of side effects
Adaptation
Body mass
Body weight
Caloric intake
Cholesterol blood level
Clinical trial
Colon flora
Controlled clinical trial
Diarrhea
Diet supplementation
Dietary fiber
Double blind procedure
Drug excretion
Drug tolerability
Enzyme activity
Feces analysis
Fermentation technique
Food composition
Food intake
Food preference
Gastrointestinal symptom
Habituation
Hematological parameters
Hunger
Hydrogen breath test
Macronutrient
PH measurement
Quality of life
Randomized controlled trial
Satiety
Adaptation, Physiological
Dextrins
Dose-Response Relationship, Drug
Polysaccharides
Probiotics
Questionnaires
To reference this document use:
http://resolver.tudelft.nl/uuid:c22452b5-3bcc-4752-b075-121f5322fef0
DOI
https://doi.org/10.1038/sj.ejcn.1602418
TNO identifier
239396
ISSN
0954-3007
Source
European Journal of Clinical Nutrition, 60 (8), 1024-1034
Document type
article