Title
Assessment of the multi-mycotoxin-binding efficacy of a carbon/aluminosilicate-based product in an in vitro gastrointestinal model
Author
Avantaggiato, G.
Havenaar, R.
Visconti, A.
TNO Kwaliteit van Leven
Publication year
2007
Abstract
A laboratory model, set to simulate the in vivo conditions of the porcine gastrointestinal tract, was used to study the small intestinal absorption of several mycotoxins and the effectiveness of Standard Q/FIS (a carbon/aluminosilicate-based product) in reducing mycotoxin absorption when added to multitoxin-contaminated diets. Mycotoxins were quickly absorbed in the proximal part of the small intestine at levels of 105 and 89% for fumonisins B1 and B2, respectively, 87% for ochratoxin A, 74% for deoxynivalenol, 44% for aflatoxin B1, and 25% for zearalenone. Addition of Standard Q/FIS to the diet (up to 2%, w/w) significantly reduced mycotoxin absorption, in a dose-dependent manner, up to 88% for aflatoxin B 1, 44% for zearalenone, and 29% for the fumonisins and ochratoxin. Standard Q/FIS was ineffective in reducing deoxynivalenol uptake. These findings suggest that Standard Q/FIS can be used as a multitoxin adsorbent material to prevent the individual and combined adverse effects of mycotoxins in animals. © 2007 American Chemical Society.
Subject
Biology
Biomedical Research
Aflatoxins
Fumonisins, deoxynivalenol
Mycotoxin binders
Mycotoxin detoxification
Mycotoxins
Ochratoxins
Zearalenone
Aluminosilicic acid
Aluminum silicate
Carbon
Adsorption
Animal food
Binding site
Biological model
Metabolism
PH
Physiology
Stomach emptying
Adsorption
Aluminum Silicates
Animal Feed
Animals
Binding Sites
Carbon
Gastric Emptying
Gastrointestinal Tract
Gastrointestinal Transit
Hydrogen-Ion Concentration
Models, Biological
Swine
Animalia
Sus
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http://resolver.tudelft.nl/uuid:be24bd0b-06eb-4cfc-abf5-03ea1073d649
DOI
https://doi.org/10.1021/jf0702803
TNO identifier
240031
ISSN
0021-8561
Source
Journal of Agricultural and Food Chemistry, 55 (12), 4810-4819
Document type
article