Print Email Facebook Twitter Anthropometry, physical activity, and endometrial cancer risk: Results from the Netherlands Cohort Study Title Anthropometry, physical activity, and endometrial cancer risk: Results from the Netherlands Cohort Study Author Schouten, L.J. Goldbohm, R.A. van den Brandt, P.A. TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO Publication year 2004 Abstract Although obesity is an established risk factor for endometrial cancer, evidence linking risk to height, weight change since age 20, and physical activity is limited. In this case-cohort study, 62 573 women from The Netherlands Cohort Study on Diet and Cancer were followed up from 1986 to 1995, and 226 endometrial cancer case patients were identified. In Cox proportional hazards analyses, women 175 cm or taller had an increased risk of endometrial cancer compared with those less than 160 cm (rate ratio [RR] = 2.57, 95% confidence interval [CI] = 1.32 to 4.99). Compared with women with a body mass index (BMI; kg/m2 between 20 and 22.9, women with a BMI of 30 or greater had a higher risk (RR = 4.50, 95% CI = 2.62 to 7.72; Ptrend<.001). Moreover, BMI at age 20 and BMI gain since age 20 were positively associated with endometrial cancer risk (Ptrend = .02 and <.001, respectively). Women who spent 90 minutes per day or more doing nonoccupational physical activities had a lower risk (RR = 0.54, 95% CI = 0.34 to 0.85; Ptrend = .002) compared with those who spent less than 30 minutes per day. High BMI and low physical activity were strong and independent risk factors for endometrial cancer. © Oxford University Press 2004, all rights reserved. Subject HealthFood and Chemical Risk AnalysisCancer riskConfidence intervalControlled studyEndometrium cancerEvidence based medicineFemaleFollow upHigh risk populationMajor clinical studyNonbiological modelObesityPhysical activityCase control studyCohort analysisEndometrium tumorFeeding behaviorProportional hazards modelRiskAdultAgedAnthropometryBody HeightBody Mass IndexBody WeightCase-Control StudiesCohort StudiesEndometrial NeoplasmsFemaleFood HabitsHumansMiddle AgedMotor ActivityMultivariate AnalysisNetherlandsOdds RatioProportional Hazards Models To reference this document use: http://resolver.tudelft.nl/uuid:b1323988-89a5-4fc8-84e0-43d87d97030b DOI https://doi.org/10.1093/jnci/djh291 TNO identifier 238087 ISSN 0027-8874 Source Journal of the National Cancer Institute, 96 (21), 1635-1638 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.