Title
Hemodynamic effects of intermittent manual lung heperinflation in patients with septic shock
Author
TNO Biomedical Instrumentation
Jellema, W.T.
Groeneveld, A.B.Johan
van Goudoever, J.
Wesseling, K.H.
Westerhof, N.
Lubbers, M.J.
Kesecioglu, J.
van Lieshout, J.J.
Publication year
2000
Abstract
OBJECTIVE: The purposes of this study were to investigate the hemodynamic changes induced by intermittent manual lung hyperinflation (MHI) and to assess if these changes are adverse enough to warrant prohibition of MHI as a routine procedure in the care of patients with septic shock. DESIGN: The study's design was experimental prospective. SETTING: The settings were university hospital intensive care units. PATIENTS: Subjects included 13 consecutive mechanically ventilated patients with septic shock who met the inclusion criteria. MEASUREMENTS AND RESULTS: Phasic MHI-related increments in mean inspiratory airway pressure were concordant to changes in mean pulmonary artery pressure (MPAP) (r2 = 0.67) with a 0.6 mm Hg rise in MPAP per cm H2O airway pressure. The magnitude of MPAP changes was not reflected in magnitude of stroke volume index (SVI) (r2 = 0.06). On average, MHI did not induce statistically significant hemodynamic changes and mean values returned to baseline level within 15 minutes. SVI during MHI increased slightly in 9 patients, from 37 ± 15 (mean ± SD) to 41 ± 17 mL/m2 (P
Subject
Dopamine
Aged BArtificial ventilation
Bacterial pneumonia
Blood culture
Clinical article
Critical illness
Heart left ventricle function
Hemodynamic parameters
Intermittent manual lung hyperinflation
Lung mechanics
Lung volume
Septic shock
Survival rate
Tracheobronchial toilet
Treatment outcome
Adult
Cardiac Output
Female
Human
Male
Middle Age
Prospective Studies
Respiration, Artificial
Shock, Septic
Stroke Volume
Support, Non-U.S. Gov't
Vascular Resistance
Ventricular Function, Left
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DOI
https://doi.org/10.1067/mhl.2000.109697
TNO identifier
235702
ISSN
0147-9563
Source
Heart and Lung: Journal of Acute and Critical Care, 29 (29), 356-366
Document type
article