Title
Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis
Author
TNO Preventie en Gezondheid
Tchetverikov, I.
Lard, L.R.
de Groot, J.
Verzijl, N.
TeKoppele, J.M.
Breedveld, F.C.
Huizinga, T.W.J.
Hanemaaijer, R.
Publication year
2003
Abstract
Objective: To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix metalloproteinase (MMP) activity in α2 macroglobulin (α2M)/MMP complexes and the progression of joint destruction in patients with recent onset rheumatoid arthritis (RA). Methods: 109 patients with RA of recent onset were entered into this longitudinal study. Patients were followed up for two years; clinical data, blood samples, and radiographs were obtained at baseline and at 1 and 2 years. Serum levels of MMPs were measured by sandwich ELISA and MMP activity assays. Results: During the two years joint damage progressed from 0 to 10 (median Sharp score, p
Subject
Biomedical Research
gelatinase B
neutrophil collagenase
stromelysin
aged
arthropathy
disease activity
disease course
disease marker
enzyme activity
enzyme blood level
enzyme linked immunosorbent assay
female
human
joint destruction
longitudinal study
major clinical study
male
prediction
rheumatoid arthritis
Adult
alpha-Macroglobulins
Arthritis, Rheumatoid
Biological Markers
C-Reactive Protein
Disease Progression
Female
Humans
Joints
Male
Matrix Metalloproteinase 3
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Middle Aged
Prospective Studies
Statistics, Nonparametric
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DOI
https://doi.org/10.1136/ard.62.11.1094
TNO identifier
237374
ISSN
0003-4967
Source
Annals of the Rheumatic Diseases, 62 (62), 1094-1099
Document type
article