Title
Fasting ghrelin does not predict food intake after short-term energy restriction
Author
Blom, W.A.M.
Mars, M.
Hendriks, H.F.J.
de Groot, L.C.P.G.M.
Stafleu, A.
Kok, F.J.
de Graaf, C.
TNO Kwaliteit van Leven
Publication year
2006
Abstract
Objective: To study the role of ghrelin as a hunger signal during energy restriction and to test the hypothesis that changes in fasting leptin concentrations during energy restriction are associated with changes in fasting ghrelin concentrations. Research Methods and Procedures: Thirty-five healthy, lean men (23 ± 3 years of age; BMI: 22.3 ±1.6 kg/m2) participated in a controlled intervention study. Fasting ghrelin and leptin concentrations were measured before and after 2 days of 62% energy restriction and after a 2-day period of ad libitum food intake. Energy intake during the latter period was assessed. Results: On average, ghrelin concentrations did not change (0.05 μg/liter; 95% confidence interval, -0.03; 0.12) during energy restriction. Changes in ghrelin concentration during energy restriction were not associated with energy intake during the ad libitum period (r = 0.07; not significant). Ad libitum energy intake was, however, associated with the change in ghrelin concentrations during the same period (r = -0.34; p = 0.05). Ghrelin and leptin concentrations were not associated. In addition, the ratio of percentage changes in ghrelin and leptin during energy restriction was not correlated with ad libitum food intake after energy restriction (r = -0.26; p = 0.14). Discussion: Fasting ghrelin concentrations did not rise after a 2-day energy restriction regimen. Moreover, changes in ghrelin concentrations during energy restriction were not associated with subsequent ad libitum food intake, suggesting that fasting ghrelin does not act as a hunger signal to the brain. The data did not support our hypothesis that leptin suppresses ghrelin levels. Copyright © 2006 NAASO.
Subject
Nutrition
Biomedical Research
Energy intake
Energy restriction
Hunger
Leptin
Men
ghrelin
peptide hormone
adolescent
adult
article
blood
caloric intake
caloric restriction
clinical trial
controlled clinical trial
controlled study
diet restriction
eating
feeding behavior
human
male
middle aged
physiology
prediction and forecasting
time
Adolescent
Adult
Caloric Restriction
Eating
Energy Intake
Fasting
Feeding Behavior
Humans
Male
Middle Aged
Peptide Hormones
Predictive Value of Tests
Time Factors
To reference this document use:
http://resolver.tudelft.nl/uuid:a86eb77d-43da-42ba-8f89-37e075c7ce52
DOI
https://doi.org/10.1038/oby.2006.97
TNO identifier
239262
ISSN
1930-7381
Source
Obesity, 14 (5), 838-846
Document type
article