Print Email Facebook Twitter Vitamin A intervention: Short-term effects of a single, oral, massive dose on iron metabolism Title Vitamin A intervention: Short-term effects of a single, oral, massive dose on iron metabolism Author Bloem, M.W. Wedel, M. van Agtmaal, E.J. Speek, A.J. Saowakontha, S. Schreurs, W.H.P. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1990 Abstract A group of 134 school children aged 3-9 y, with signs of conjunctival xerosis, from the rural area of Sakorn Nakhon province of Northeast Thailand were selected for a controlled study on the short-term effect (2 wk) of a single, oral high dose of vitamin A on iron metabolism. After collection of the baseline data, children within villages were randomly assigned to receive the capsules (n = 65) or serve as control subjects (n = 69). Two weeks after supplementation significant increases of retinol, retinol-binding protein, hemoglobin, hematocrit, serum iron, and saturation of transferrin were found in the supplemented group. Ferritin concentrations did not change significantly. These short-term changes completely exclude seasonal effects and change in morbidity. This study provides evidence of a causal association between vitamin A and iron metabolism. In areas where vitamin A deficiency is endemic, periodic massive vitamin A dose programs can also improve iron status of the population. Subject Northeast ThailandVitamin A supplementationVitamin A-iron interactionRetinolAnemiaIron metabolismNormal humanOral drug administrationSchool childAdministration, OralChildDose-Response Relationship, DrugFemaleHumanIronMaleNutritional RequirementsNutritional StatusRural PopulationSupport, Non-U.S. Gov'tThailandVitamin AVitamin A Deficiency To reference this document use: http://resolver.tudelft.nl/uuid:a0ae8d91-13d2-4ab3-a1a7-d4a3776cf261 TNO identifier 231115 ISSN 0002-9165 Source American Journal of Clinical Nutrition, 51 (1), 76-79 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.